A5014695294- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
- Ginger and Zingiberaceae research
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Plant nutrient uptake and metabolism
- Pediatric health and respiratory diseases
- 14-3-3 protein interactions
- Microbial Natural Products and Biosynthesis
- Lipid metabolism and biosynthesis
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Bioactive natural compounds
- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Digestive system and related health
- RNA Interference and Gene Delivery
Chinese PLA General Hospital
2022
Shenzhen University
2011-2021
Gansu Agricultural University
2021
Zhejiang A & F University
2019
Nanjing University of Chinese Medicine
2016
Jiangsu Provincial Academy of Traditional Chinese Medicine
2016
Tianjin Medical University
2009
MicroRNAs (miRNAs) are small, non-coding RNAs capable of postranscriptionally regulating gene expression. Accurate expression profiling is crucial for understanding the biological roles miRNAs, and exploring them as biomarkers diseases.A novel, highly sensitive, reliable miRNA quantification approach,termed S-Poly(T) assay, designed. In this miRNAs subjected to polyadenylation reverse transcription with a primer that contains universal primer, Taqman probe, an oligo(dT)(11) sequence six...
Abstract Here, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages and therapeutic efficacy MBF diet mice with dextran sulfate sodium (DSS)-induced acute colitis MUC2 −/− colorectal cancer. In vitro , LPS-induced nitric oxide (NO) production was significantly inhibited by via suppressing expression proinflammatory molecules, including inducible synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1...
Centrosomal abnormalities have been found in various cancer types. We sought to determine whether centrosomal dysfunctions occur the atypical ductal hyperplasia (ADH)-carcinoma sequence of breast cancer. As alpha and gamma-tubulins are structural components centrosomes, we performed real time quantitative polymerase chain reaction (qPCR), situ hybridization (ISH) immunnohistochemistry (IHC) DNA copy levels, messenger RNA (mRNA) expression, protein expression respectively. Gamma-tubulin...
Mice are widely used as an animal model for studying human uterine receptivity embryo implantation. Although transcriptional changes related to mouse have been determined by using bulk RNA-seq, the data of limited value because uterus is a complex organ consisting many cell types. Here, we aimed decipher implantation at single-cell resolution.Single-cell RNA sequencing was performed pre-receptive and receptive uterus. Gene expression profiles in luminal epithelium glandular were validated...
Ferroptosis-related lncRNAs are promising biomarkers for predicting the prognosis of many cancers. However, a ferroptosis-related signature to predict cutaneous melanoma (CM) has not been identified. The purpose this study was construct lncRNA and immunotherapy efficacy in CM.Ferroptosis-related differentially expressed genes (FDEGs) (FDELs) were identified using TCGA, GTEx, FerrDb datasets. We performed Cox LASSO regressions identify key FDELs, constructed risk score stratify patients into...
Abstract Background Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related death in world. Although improvement treatment has significantly prolonged survival NSCLC patients, patients still face recurrence because drug resistance. Therefore, it urgent to find more effective drugs improve and rate patients. Methods Network pharmacology tools were comprehensive applied analyze β-elemene anticancer effects evaluated both vitro vivo. What’s more, underlying mechanisms...