A5064802725- Diet, Metabolism, and Disease
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- TGF-β signaling in diseases
- Autophagy in Disease and Therapy
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Drug Transport and Resistance Mechanisms
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- Metabolism, Diabetes, and Cancer
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
Tianjin Medical University Cancer Institute and Hospital
2015-2025
Hôpital de Cery
2023-2024
University of Lausanne
2024
Ministry of Education of the People's Republic of China
2020-2022
Inner Mongolia Medical University
2019
National Public Health Laboratory
1996-2016
Tianjin Medical University
2005-2015
Tianjin Medical University General Hospital
2013
Janssen (Belgium)
2013
The University of Texas MD Anderson Cancer Center
2013
Abstract Somatic mutations and large‐scale depletion in mitochondrial DNA (mtDNA) have been extensively detected various human cancers. However, it still remains unclear whether the alterations mtDNA content are related to clinicopathological parameters patient prognosis breast cancer. In present study, we analyzed copy number of 59 cases invasive tumors paired nontumorous tissues using quantitative real‐time PCR. Our data showed that level was significantly decreased tumor as compared...
Abstract Background Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established. Furthermore, it not clear whether MMP-13 can used as an independent cancer biomarker. This study was conducted assess the expression profile of in invasive carcinomas determine diagnostic and prognostic significance, well correlation with other biomarkers including estrogen receptor (ER), progesterone...
Transforming growth factor-beta (TGF-β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness advanced stages. The dual effect TGF-β on development is known paradox, remarkable functional conversion pivotal controversial phenomenon that has been widely investigated for decades. This may be attributed to cross talk between signaling other pathways, including EGF receptor (EGFR) during progression. However,...
Our aim was to investigate whether microRNAs can predict the clinical outcome of patients with gastric cancer. We used integrated analysis microRNA and mRNA expression profiles identify cancer subtypes their underlying regulatory scenarios.MicroRNA-based were identified by consensus clustering 90 tissues. Activated pathways in gene profiles. Further conducted model a network for each subtype. RNA protein analyzed RT-PCR tissue microarray, respectively, cohort 385 cases (including profiling)...
Rationale: Angiogenesis is a fundamental process of tumorigenesis, growth, invasion and metastatic spread.Extracellular vesicles, especially exosomes, released by primary tumors promote angiogenesis cancer progression.However, the mechanism underlying pro-angiogenic potency cell-derived exosomes remains poorly understood.Methods: Exosomes were isolated from breast cells with high potential (HM) low (LM).The effects these evaluated in vitro tube formation assays, wound healing rat arterial...
As the primary microtubule-organizing centers, centrosomes require γ-tubulin for microtubule nucleation and organization. Located in close vicinity to centrosomes, Golgi complex is another organelle interphase cells. CDK5RAP2 a complex-binding protein functions attachment centrosomes. In this study, we find that localizes an ATP- centrosome-dependent manner associates with membranes independently of microtubules. contains centrosome-targeting domain its core region highly homologous Motif 2...
Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass flavonoids present in fruits and vegetables. The involvement autophagy apigenin-induced apoptotic death human breast cancer cells was investigated. Cell proliferation viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) clonogenic assays. Flow cytometry, fluorescent staining Western blot analysis employed to detect apoptosis autophagy, role using inhibitors. dose- time-dependently...
Abstract Malignant gliomas have a tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. The serine/threonine kinase Akt2 is well known as an important regulator of cell survival and growth. In this study, we show that siRNA‐mediated depletion inhibited migration invasion glioma cells. addition, demonstrate the mechanisms by which functions promote invasion. Phosphorylation cofilin, critical step actin polymerization,...
// Tong Wang 1,* , Jie Yuan Zhang 1 Ran Tian Wei Ji Yan Zhou Yi Yang Weijie Song Fei and Ruifang Niu Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center for Cancer, The Key Laboratory of Breast Prevention Therapy, Ministry Education, Tianjin, PR China * These authors have contributed equally to this work Correspondence to: Niu, email: Zhang, Keywords : Anxa2, breast cancer, epithelial–mesenchymal transition, epidermal growth factor receptor Received...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and third cancer in Asia. HCC has heterogeneous etiologic molecular profiles a varied response to therapeutics. The high recurrence rate curtailed survival this are attributed its resistance therapy. ultimate goal develop more effective personalized therapeutic strategy for HCC, but first step system classifying disease on basis of biomarkers. To that end, we performed mRNA microRNA (miRNA) expression profiling 100...
Anxa2 is the most studied member of calcium-mediated phospholipid-binding protein family annexins and a biomarker in cancers. In this review, we listed clinical findings confirmed value early diagnosis prognostic prediction due to its overexpression adverse effect on outcome tumors. plays pivotal role cancer cell proliferation, migration, invasion, metastasis, treatment resistance. Improved understanding cancer-promoting function might make it an ideal target for therapy. Here,...
Abstract Tumor metastasis induced by drug resistance is a major challenge in successful cancer treatment. Nevertheless, the mechanisms underlying pro-invasive and metastatic ability of remain elusive. Exosome-mediated intercellular communications between cells stromal tumor microenvironment are required for initiation progression. Recent reports have shown that also promote aggression. However, little attention has been regarded on this aspect. Herein, we demonstrated drug-resistant...
Multidrug resistance (MDR) is the major cause of failure in cancer chemotherapy. Recent reports even suggest that MDR associated with elevated invasion and metastasis tumor cells. In current study, we used a proteomic approach to identify genes play an important role induced cell migration. 2D-PAGE MALDI-TOF/MS-based proteomics were separate differentially expressed proteins between MCF-7 MCF-7/ADR, p-glycoprotein-overexpressing adriamycin-resistance breast line. Annexin a2 (Anxa2) was...
The purpose of this study was to use polymeric liposomes (PLs) with a targeting ligand (folate) coat superparamagnetic iron oxide nanoparticles (SPIONs) and transfer the magnetic from organic phases aqueous solutions, further evaluate their efficacy as resonance imaging (MRI) contrast agent. formed exhibited narrow range size dispersity (core particles is about 8-10 nm) relatively high T2 relaxivities (r2 = 164.14 s(-1) mM(-1) for folate-PLs-coated SPIONs). in vitro tumor cell folate...