A5032590404- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Pericarditis and Cardiac Tamponade
- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Cardiac tumors and thrombi
- Pancreatitis Pathology and Treatment
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Dialysis and Renal Disease Management
- RNA modifications and cancer
- Urinary Tract Infections Management
- Management of metastatic bone disease
- Renal Diseases and Glomerulopathies
- DNA Repair Mechanisms
- Head and Neck Cancer Studies
Tianjin Medical University Cancer Institute and Hospital
2021-2023
Ministry of Education of the People's Republic of China
2021-2022
Chongqing Normal University
2019
Guangxi Medical University
2012
First Affiliated Hospital of GuangXi Medical University
2012
Rationale: Angiogenesis is a fundamental process of tumorigenesis, growth, invasion and metastatic spread.Extracellular vesicles, especially exosomes, released by primary tumors promote angiogenesis cancer progression.However, the mechanism underlying pro-angiogenic potency cell-derived exosomes remains poorly understood.Methods: Exosomes were isolated from breast cells with high potential (HM) low (LM).The effects these evaluated in vitro tube formation assays, wound healing rat arterial...
Abstract Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under glucose-deficient...
Abstract The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with multifunctional and multifaceted properties. By mediating protein-protein interactions, RACK1 integrates multiple intracellular signals involved in the regulation of various physiological pathological processes. Dysregulation has been implicated initiation progression many tumors. However, exact function cancer cellular processes, especially proliferation, remains controversial. Here, we show that...
Fructose is a very common sugar found in natural foods, while current studies demonstrate that high fructose intake significantly associated with increased risk of multiple cancers and more aggressive tumor behavior, but the relevant mechanisms are not fully understood.Tumor-grafting experiments vitro angiogenesis assays were conducted to detect effect conditioned medium fructose-cultured cells on biological function vascular endothelial (VECs) angiogenesis. 448 colorectal cancer specimens...
We conducted a study to investigate the role of excision repair cross-complimentary group 1 gene (ERCC1)-xeroderma pigmentosum complementation F (XPF) polymorphisms in response chemotherapy and clinical outcome gastric patients. Three SNPs ERCC1 (rs11615, rs3212986, rs2298881) two XPF (rs2276465 rs6498486) were extracted using Tiangen DNA kit (Tiangen Biotech, Beijing, China) according manufacturer's instructions. The median follow-up time was 36.4 months, ranged from 2-60 months. During...
Angiotensin-converting enzyme 2 (ACE2) is a key of the renin-angiotensin system and well-known functional receptor for entry severe acute respiratory syndrome coronavirus (SARS-CoV-2) into host cells. The COVID-19 pandemic has brought ACE2 spotlight, expression in tumors its relationship with SARS-COV-2 infection prognosis cancer patients have received extensive attention. However, association between tumor therapy prognosis, especially breast cancer, remains ambiguous requires further...
Splicing factors (SFs) are proteins that control the alternative splicing (AS) of RNAs, which have been recognized as new cancer hallmarks. Their dysregulation has found to be involved in many biological processes cancer, such carcinogenesis, proliferation, metastasis and senescence. Dysregulation SFs demonstrated contribute progression prostate (PCa). However, a comprehensive analysis prognosis value PCa is limited. In this work, we systematically analysed 393 deeply characterize expression...
ATP-binding cassette (ABC) transporter family are major contributors to the drug resistance establishment of breast cancer cells. Breast resistant protein (BCRP), one ABC transporters, has long been recognized as a pump that effluxes therapeutic drugs against concentration gradient. However, recent studies suggest biological function BCRP is not limited in its activity. Herein, role proliferation and survival drug-resistant cells was investigated. We found efflux epirubicin express multiple...
Abstract Stomach cancer involves hypoxia-specific microenvironments. Stoichiogenomics explores environmental resource limitation on biological macromolecules in terms of element usages. However, the patterns oxygen usage by proteins and ways that adapt to a hypoxia microenvironment are still unknown. Here we compared carbon contents ([C]) between proteomes stomach (hypoxia) two glandular cells (normal). Key proteins, genome locations, pathways, functional dissection associated with were also...
Recent evidence suggests that splicing factors (SFs) and alternative (AS) play important roles in cancer progression. We constructed four SF-risk-models using 12 survival-related SFs. In Luminal-A, Luminal-B, Her-2, Basal-Like BRCA, for three genes ( PAXBP1 , NKAP NCBP2 ), RBM15B PNN ACIN1 SRSF8 LSM3 SNRNP200 SNU13 SRPK3 PUF60 ) were constructed. These models have a promising prognosis-predicting power. The co-expression protein-protein interaction analysis suggest the SFs are highly...
Peritoneal dialysis (PD) related infections, such as peritonitis, are still the main obstacle for development of PD. Prophylactic antibiotic one interventions to prevent early peritonitis was recommended use before PD catheter insertion by International Society Dialysis (ISPD) guidelines, In our hospital, however, since 2012, prophylactic antibiotics catheters were not allowed because hospital's regulation. order analyze outcomes patients without using insertion, we compared with or...
<div>Abstract<p>Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under...
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<p>Supplementary data</p>
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<p>Figure S3</p>
<div>Abstract<p>Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under...
<p>Figure S3</p>
<p>Figure S6</p>
<p>Figure s4</p>