A5100736506- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Lupus Erythematosus Research
- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Vasculitis and related conditions
- Iron Metabolism and Disorders
- PARP inhibition in cancer therapy
- Parathyroid Disorders and Treatments
- Renin-Angiotensin System Studies
- Bipolar Disorder and Treatment
- Tea Polyphenols and Effects
- Diabetes Treatment and Management
- Nuclear Receptors and Signaling
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Infectious Disease Case Reports and Treatments
- Carbon and Quantum Dots Applications
- Potassium and Related Disorders
- Microbial metabolism and enzyme function
Yibin Vocational and Technical College
2024
Yibin University
2024
Qilu Hospital of Shandong University
2013-2022
Shandong University
2009-2022
Shanghai University
2017
Shuguang Hospital
2017
Shanghai University of Traditional Chinese Medicine
2017
First Affiliated Hospital of Dalian Medical University
2017
Dalian Medical University
2017
University of North Carolina at Chapel Hill
2002-2003
Background. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has threatened every civilian as a global pandemic. The immune system poses the critical interactive chain between human body and virus. Here, we make efforts to examine whether comorbidity with type diabetes (T2D) affects immunological response in patients. Methods. We conducted retrospective pilot study investigating characteristics of confirmed cases or without comorbid T2D. Two subcohorts sex-...
Cisplatin (CP)-induced nephrotoxicity hampers its application in clinic. Green tea, particularly predominant polyphenolic constituent epigallocatechin-3-gallate (EGCG), possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. The present study was designed to investigate the protective effects of EGCG against CP-induced mice. Male C57/BL6 mice different groups received single injection CP (20 mg/kg) (100 various sets kidney tissues blood were collected after killing. Then,...
Acute kidney injury is a clinical syndrome characterized by loss of renal function and acute tubular necrosis. Resveratrol exerts wide range pharmacological effects based on its anti‑inflammatory, antioxidant cytoprotective properties. The present study aimed to evaluate whether resveratrol attenuates in cisplatin‑induced rat model investigate the potential mechanisms involved. Rats were randomly divided into four treatment groups: control, cisplatin, resveratrol, cisplatin plus resveratrol....
To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients.We retrospectively investigated clinical, imaging, laboratory characteristics patients confirmed COVID-19 who were hospitalized from January 30, 2020 to March 17, 2020, at Renmin Hospital Wuhan University. A detailed record was kept for each subject, including medical history physical examinations. total 164 subjects eligible study, among...
Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of a large cohort AAV patients.A 219 complete after induction therapy at our center was retrospectively studied, and their laboratory data as well long-term outcomes were analyzed.A total 80 out had AAV. Compared without remission, slope...
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, female preponderance and seropositivity for autoantibodies such as anti-smooth muscle actin and/or anti-nuclear, anti-liver kidney microsomal type 1 (anti-LKM1) cytosol (anti-LC1) in more than 80% of cases. AIH linked strongly to several major histocompatibility complex (MHC) alleles, including human leucocyte antigen (HLA)-DR3, -DR7 -DR13. HLA-DR4 has the second strongest association with adult...
Background and Aim: Lymphocytes play an important role in fighting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Low total lymphocyte count (TLC), which contributes to poor clinical outcomes, is common persons with disease 2019 (COVID-19). The current explanation for the cause of low TLC that it directly related invasiveness SARS-CoV-2, attacks lymphocytes. We hypothesized malnutrition development early-stage COVID-19. Methods: prospectively enrolled 101 patients...
SUMMARY: Aim: Pauci‐immune crescentic glomerulonephritis (CrGN) is frequently associated with circulating anti‐neutrophil cytoplasmic antibodies (ANCA). However, in patients ANCA‐negative pauci‐immune CrGN, the pathogenesis not clear. Anti‐endothelial cell (AECA) have been implicated of vasculitis. The purpose this study to investigate prevalence AECA and their possible clinical significance CrGN. Methods: Sera from 19 26 ANCA‐positive CrGN 10 healthy blood donors were collected. Soluble...
Background: Chronic kidney disease (CKD) with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage are limited. This study aimed assess efficacy safety of traditional Chinese medicine, Niaoduqing particles, in patients stage 3b-4 CKD. Methods: The present was a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial. From May 2013 December 2013, 300 CKD estimated...
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may persist in patients with disease 2019 (COVID-19) despite receiving standard care. Methods: In this pilot study of hospitalized adult (≥18 years age), radiologically confirmed pneumonia who were SARS-CoV-2 positive for more than 28 days care, assigned to receive care (SOC, grp I) or leflunomide + SOC (grp 2). After weeks, 1 and continued be SARS-CoV-2-positive received 14 while continuing SOC. primary outcomes...
Objective There are many adverse reactions due to clindamycin, but kidney diseases (acute injury, AKI) uncommon. However, in recent years, the rate of clindamycin-induced has increased. We analyzed 50 patients with retrospectively, and investigated characteristics these order provide a reference for rational clinical drug use reduce drug-induced organ damage. Methods diagnosed retrospectively at Department Nephrology, Shandong University Qilu Hospital, from January 2009 December 2013. The...
The aim of the present study was to investigate protective effect tacrolimus on early podocyte damage in rats with diabetic nephropathy (DN). A total 38 normal male Sprague‑Dawley were randomly divided into four groups: Normal control group (group N; n=8), DN (n=10), (FK506) treatment F; n=10), benazepril (Lotensin) L; n=10). groups DN, F and L administered streptozotocin (STZ; 60 mg/kg) by intraperitoneal injection establish rat model. After 4 weeks, model established, different...
The study explored the correlations of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) gene polymorphisms with susceptibility condition primary nephrotic syndrome. A total 200 patients syndrome in Qilu hospital were collected as disease group, healthy people selected control group. Genomic deoxyribonucleic acids (DNAs) nucleated cells peripheral blood extracted to detect TNF-α (rs1799724 rs1800629) IL-10 (rs1800872 rs141219090). Allele distributions at rs1799724 (P=0.003)...
ABSTRACT OBJECTIVE To evaluate the safety and efficacy of leflunomide for treatment refractory COVID-19 in adult patients. DESIGN Open-label controlled study SETTING A designated hospital patients with Wuhan, China. PARTICIPANTS 27 hospitalized (≥18 years age) radiologically confirmed pneumonia SARS-CoV-2 positive more than 28 days despite standard care were assigned to receive (SOC, grp I) or + SOC (grp 2). After 2 weeks, 1 who continued be SARS-CoV-2-positive received 14 while continuing...
Recent studies in animal models have revealed that mycophenolate mofetil (MMF) has certain protective effects against experimental diabetic nephropathy. The present study therefore aimed to investigate the hypothesis nephropathy may be ameliorated by and benazepril treatment alone or combination, identify potential underlying mechanisms a rat model. Diabetes was induced rats single intraperitoneal injection of streptozotocin. Rats were subsequently treated with benazepril, MMF combination...