A5100737327- Biomedical Research and Pathophysiology
- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Chemotherapy-induced organ toxicity mitigation
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Dialysis and Renal Disease Management
- Advanced Malware Detection Techniques
- Genomics and Rare Diseases
- Advanced Glycation End Products research
- Physical Unclonable Functions (PUFs) and Hardware Security
- Mesenchymal stem cell research
- Signaling Pathways in Disease
- Orthopedic Infections and Treatments
- Renal and Vascular Pathologies
Qilu Hospital of Shandong University
2014-2024
Zhejiang University
2011-2024
South China University of Technology
2015-2024
Army Medical University
2024
Southwest Hospital
2024
University of California, Santa Barbara
2016-2023
Shandong University
2013-2022
Chongqing Medical University
2017
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
State Administration of Traditional Chinese Medicine of the People's Republic of China
2014
Abstract MicroRNA-155 (miR-155) was previously found involved in the development of systemic lupus erythematosus (SLE) and other autoimmune diseases inflammatory response; however, detailed mechanism miR-155 SLE is not fully understood. To explore vivo role pathogenesis SLE, miR-155–deficient Faslpr/lpr (miR-155−/−Faslpr/lpr) mice were obtained by crossing miR-155−/− mice. Clinical features such as glomerulonephritis, autoantibody levels, immune system cell populations compared between...
Cisplatin (CP) is used as an antineoplastic drug in the clinic, but its nephrotoxicity limits use. Grape seed proanthocyanidin extract (GSPE) a powerful antioxidant. In this study, we investigated whether GSPE can prevent CP-induced and explored underlying mechanism. Male C57/BL6 mice were randomly divided into four groups: control group (N), CP (C), receiving intraperitoneal (ip) injection of 20 mg/kg CP, (G), intragastric (ig) dose 500 GSPE, CP+GSPE (C+G), where ig administration was...
<i>Aims:</i> We prospectively compared the effects of oral mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) combined with corticosteroids for induction therapy microscopic polyangiitis (MPA) renal involvement over a follow-up period 6 months. <i>Methods:</i> 41 MPA patients were randomly assigned to either open-label MMF group IVC group. Patients in (n = 19) received 1.0 g/day (1.5 body weight >70 kg) and 22) monthly pulses g per pulse (0.8 <50...
Cisplatin (CP)-induced nephrotoxicity hampers its application in clinic. Green tea, particularly predominant polyphenolic constituent epigallocatechin-3-gallate (EGCG), possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. The present study was designed to investigate the protective effects of EGCG against CP-induced mice. Male C57/BL6 mice different groups received single injection CP (20 mg/kg) (100 various sets kidney tissues blood were collected after killing. Then,...
Acute rejection (AR) and acute tubular necrosis (ATN) are main causes of early renal allograft dysfunction. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) Diffusion weighted (DW) MRI can provide valuable information about changes bioavailability water diffusion by measuring R2* or apparent coefficient (ADC) respectively. We aimed to determine the value BOLD DW in detecting for dysfunction recipients. Fifty patients received allografts from deceased donors were analyzed,...
Diabetic kidney disease (DKD) is the most prevalent chronic disease. Macrophage infiltration in critical for progression of DKD. However, underlying mechanism far from clear. Cullin 4B (CUL4B) scaffold protein CUL4B-RING E3 ligase complexes. Previous studies have shown that depletion CUL4B macrophages aggravates lipopolysaccharide-induced peritonitis and septic shock. In this study, using two mouse models DKD, we demonstrate myeloid deficiency alleviates diabetes-induced renal injury...
Wogonin, an active component derived from Scutellaria baicalensis, has shown anti-tumor activities in several malignancies. However, the roles of wogonin RCC cells remain elusive. Here, we explored effects on and underlying mechanisms. We found that showed significant cytotoxic against cell lines 786-O OS-RC-2, with much lower human normal embryonic kidney line HEK-293 cells. Wogonin treatment dramatically inhibited proliferation, migration invasion further by inhibiting CDK4-RB pathway,...
Mutations in the gene encoding polycystin-1 (PC1) are most common cause of autosomal dominant polycystic kidney disease (ADPKD). Cysts ADPKD exhibit a Warburg-like metabolism characterized by dysfunctional mitochondria and aerobic glycolysis. PC1 is an integral membrane protein with large extracellular domain, short C-terminal cytoplasmic tail shares structural functional similarities G protein-coupled receptors (GPCRs). Its exact function remains unclear. The undergoes proteolytic cleavage,...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of function, caused by mutations in the genes encoding polycystin-1 (PC1) polycystin-2 (PC2), respectively. The PC1/PC2 complex localizes primary cilia can act as flow-dependent calcium channel addition numerous other signaling functions. exact functions polycystins, their regulation purpose are still poorly understood. PC1 an integral membrane protein with...
Human adipose tissues are an ideal source of stem cells. It is important to find inducers that can safely and effectively differentiate cells into functional neurons for clinical use. In this study, we investigate the use Radix Angelicae Sinensis as inducer neuronal differentiation. Primary human adipose-derived were obtained from adult subcutaneous fatty tissue, then pre-induced with 10% injection 24 hours, incubated in serum-free Dulbecco's modified Eagle's medium/Nutrient Mixture F-12...
Hypertension is a major global public health issue. Uncontrolled hypertension leads to organ damage, especially renal damage. Calcitriol used treat osteoporosis, promote bone formation, and increase mass. Previous studies have demonstrated that 1,25(OH)2D3, in addition its classic role, also has multiple immune regulation renoprotective functions inhibits the activity of renin-angiotensin-aldosterone system (RASS). The aim current study was investigate effects calcitriol spontaneously...
Alport syndrome (AS) is a hereditary nephropathy which characterized by molecular abnormalities in collagen IV. Here, we report compound mutations of the COL4A3 gene including novel allele identified patient with syndrome. The was 25-year-old Chinese woman. She has history proteinuria and hematuria cleft lip palate. pathologic results were consistent received ACEI treatment but did not respond well to treatment. Sequencing revealed that carried two heterozygous gene, known mutation...