A5065054922- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Inflammasome and immune disorders
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Renal Diseases and Glomerulopathies
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Autophagy in Disease and Therapy
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Inflammation biomarkers and pathways
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Gout, Hyperuricemia, Uric Acid
- Phytoestrogen effects and research
- IL-33, ST2, and ILC Pathways
- Fungal Infections and Studies
- Marine Toxins and Detection Methods
- Hidradenitis Suppurativa and Treatments
National University Hospital
2022-2024
Karolinska Institutet
2018-2022
Weifang University
2013-2021
Weifang Medical University
2002-2020
Shandong University
2013-2016
Renmin Hospital of Wuhan University
2013
Wuhan University
2013
Ochanomizu University
2002
Although the innate immune response to induce postischemic inflammation is considered as an essential step in progression of cerebral ischemia injury, role immunity mediator NLRP3 pathogenesis ischemic stroke unknown. In this study, focal was induced by middle artery occlusion −/− , NOX2 or wild-type (WT) mice. By magnetic resonance imaging (MRI), Evans blue permeability, and electron microscopic analyses, we found that deficiency ameliorated injury mice after reducing infarcts blood–brain...
Significance Liver steatosis, or fatty liver, is the most common liver disease in world, affecting up to 25% of all Americans. There currently no approved drug available for this condition, which may progress serious disease, including steatohepatitis, fibrosis, and cirrhosis. Here, we show rodent human models metabolic syndrome that steatosis can be prevented by a simple dietary approach. Inorganic nitrate, present green leafy vegetables, converted vivo nitric oxide (NO) process involving...
Abstract Histone deacetylase ( HDAC ) 9, a member of class II s, regulates wide variety normal and abnormal physiological functions, which is usually expressed at high levels in the brain skeletal muscle. Although studies have highlighted importance ‐mediated epigenetic processes development ischaemic stroke very recent genome‐wide association identified variant 9 associated with large‐vessel ischemic stroke, molecular events by induces cerebral injury keep unclear. In this study, we found...
Renal fibrosis, associated with oxidative stress and nitric oxide (NO) deficiency, contributes to the development of chronic kidney disease renal failure. As major energy source in maintaining physiological functions, tubular epithelial cells decreased fatty acid oxidation play a key role fibrosis development. Inorganic nitrate, found high levels certain vegetables, can increase formation signaling by bioactive nitrogen species, including NO, dampen stress. In this study, we evaluated...
Although hyperhomocysteinemia (hHcys) has been recognized as an important independent risk factor in the progression of end-stage renal disease and development cardiovascular complications related to disease, mechanisms triggering pathogenic actions hHcys are not yet fully understood. The present study was designed investigate contribution nucleotide-binding oligomerization domain containing 2 (NOD2), intracellular innate immunity mediator, glomerulosclerosis hHcys. Our results showed that...
Unhealthy dietary habits contribute to the increasing incidence of metabolic syndrome and type 2 diabetes (T2D), which is accompanied by oxidative stress, compromised nitric oxide (NO) bioavailability increased cardiovascular risk. Apart from lifestyle changes, biguanides such as metformin are first-line pharmacological treatment for T2D. Favourable cardiometabolic effects have been demonstrated following nitrate supplementation boost nitrate-nitrite-NO pathway. Here we aim compare...
Renal ischemia-reperfusion (IR) injury is a common cause of acute kidney (AKI), which associated with oxidative stress and reduced nitric oxide (NO) bioactivity increased risk developing chronic disease (CKD) cardiovascular (CVD). New strategies that restore redox balance may have therapeutic implications during AKI complications.To investigate the value boosting nitrate-nitrite-NO pathway development IR-induced renal dysfunction.Male C57BL/6 J mice were given sodium nitrate (10 mg/kg, i. p)...
Ligustrazine has been used to alleviate clinical acute kidney injury (AKI); however, the underlying molecular mechanisms are poorly understood. In order further elucidate mechanism its occurrence, role of nucleotide‑binding oligomerization domain‑containing 2 (NOD2) in AKI was investigated present study, and results indicated that ligustrazine exerts an important protective effect against vivo by inhibiting upregulation NOD2 expression reducing apoptosis cells following ischemia/reperfusion...
Superficial cutaneous fungal infections are common dermatologic conditions. A significant proportion do not present with typical clinical findings. However, the 10% potassium hydroxide (KOH) smear, a simple bedside test, is often underused when diagnosing infections.
Is a 2-dimensional (2D) force feedback device capable of presenting 3-dimensional (3D) shapes? The answer is qualified "yes." "Force shading", haptic counterpart bump mapping in computer graphics, presents non-flat shape on nominally flat surface by varying the vector direction rendering [Morgenbesser and Srinivasan 1996][Robles-De-La-Torre Hayward 2001]. To our knowledge, such phenomena have been qualitatively measured only 3D devices, quantitative comparison to 2D devices has not made. We...
Background. Translocator protein 18 kDa (TSPO) plays a key role both in microglial activation and neuroinflammation. Postoperative cognitive decline (POCD), notable hazard to patients society, maybe contribute deficiently controlled neuroinflammatory processes initiated by anesthesia surgery. So far it is unclear that whether TSPO involved the pathogenesis of POCD or not. Materials Methods. Twelve adult rats twelve aged were divided into control isoflurane groups respectively. was induced...
Objective To investigate the effect of clemastine fumarate on lung ischemia-reperfusion (I/R) injury in rabbits. Methods Fifty New Zealand white rabbits both sexes, weighing 2.0-3.0 kg, were divided into 3 groups using a random number table: sham operation group (Sham group, n=10), I/R (n=20) and (Cle n=20). The model was established by clamping left hilum decreasing tidal volume followed restoration perfusion ventilation 1 h later Cle groups.At Sham 2 4 reperfusion groups, blood...
Expression of syndecan-1 (SDC-1) in rats with acute kidney injury and the protective effect GM6001 on were investigated. Fifty SD selected randomly divided into control group (CG) (n=15), treatment (TCG) (n=10), module (MG) (n=15) (TG) (n=10). In TG, model renal (AKI) was established after pretreatment intraperitoneal injection one day before modeling. MG, same amount saline injected intraperitoneally modeling done CG, but not made. TCG, pretreated The contents blood urea nitrogen (BUN)...