A5090121130- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Cardiovascular Issues in Pregnancy
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Diet and metabolism studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heavy Metal Exposure and Toxicity
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Maternal and fetal healthcare
- Mercury impact and mitigation studies
- Preterm Birth and Chorioamnionitis
- Sulfur Compounds in Biology
Universidade Estadual Paulista (Unesp)
2016-2021
Karolinska Institutet
2018
Universidade de São Paulo
2017
Significance Liver steatosis, or fatty liver, is the most common liver disease in world, affecting up to 25% of all Americans. There currently no approved drug available for this condition, which may progress serious disease, including steatohepatitis, fibrosis, and cirrhosis. Here, we show rodent human models metabolic syndrome that steatosis can be prevented by a simple dietary approach. Inorganic nitrate, present green leafy vegetables, converted vivo nitric oxide (NO) process involving...
Elevated levels of myeloperoxidase have been demonstrated in women with preeclampsia where it may contribute to endothelial dysfunction mediated, part, by nitric oxide impairment. In this study, we investigated hypertensive disorders pregnancy and its contribution the impairment vasodilator oxide. We found higher supernatant from human umbilical vein cells cultures incubated plasma group compared healthy pregnant women. Further, measured concentration activity 219 women, 130 gestational...
Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy that partly responsible for both maternal and fetal morbidity mortality levels worldwide. It has been recently discovered sirtuin-1 (SIRT1) reduced in the circulation an vitro model PE. Therefore, this study, we investigated effects trans-resveratrol, potent antioxidant activator SIRT1, on oxidative stress nitric oxide (NO) production PE compared to gestational (GH) healthy pregnant (HP) women. Furthermore, also...
Lead- (Pb-) induced hypertension has been shown in humans and experimental animals cardiovascular effects of hydrogen sulfide (H 2 S) have reported previously. However, no studies examined involvement H S Pb-induced hypertension. We found increases diastolic blood pressure mean Pb-intoxicated followed by diminished plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, Pb + NaHS. received intraperitoneally (i.p.) 1st dose 8 μ...
MicroRNAs (miRNAs) play an important role in the pathophysiology of preeclampsia (PE). However, expression circulating miRNAs was not analyzed second trimester pregnancy, a period major relevance to identify predictive biomarkers for PE. Therefore, we examined profiles 84 using PCR array plasma collected between 20 and 25 weeks gestation from pregnant women, who subsequently developed PE those remained healthy during randomly selected prospective cohort. Overall, 23 had fold change >...
Aim: Over 40% of patients with pre-eclampsia are nonresponsive to antihypertensive therapy, but the underlying mechanisms unknown. We examined effects plasma from and responsive on endothelial gene expression. Patients & methods: PCR array was performed in human umbilical vein cells (HUVEC) incubated (n = 4) patients. Gene networks interactions drugs used were identified by Ingenuity Pathway Analysis. Results: Nifedipine hydralazine act upregulate or downregulate genes found be downregulated...
Preeclampsia is the major cause of maternal and fetal deaths worldwide. Circulating biomarker concentrations to predict preeclampsia must be determined. Therefore, objective was evaluate heme oxygenase‐1 (HO‐1) concentration in both plasma urine samples from pregnant women before development identify a potential for development. We performed case‐control study nested prospective cohort at University Hospital Ribeirao Preto Medical School, São Paulo (HCFMRP‐USP), Preto, Brazil. Of 1400...
We examined the interaction of polymorphisms in genes heme oxygenase-1 (HMOX1) and nitric oxide synthase (NOS3) patients with preeclampsia (PE) as well responsiveness to methyldopa total antihypertensive therapy. The HMOX1 (rs2071746, A/T) NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), levels enzyme (HO-1) measured enzyme-linked immunosorbent assay (ELISA). found interactions between genotypes HMOX-1 that PE AT...