A5100410272- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Pancreatic function and diabetes
- Sepsis Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Neonatal Respiratory Health Research
- Gout, Hyperuricemia, Uric Acid
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Research Studies
- Nanoparticle-Based Drug Delivery
- Intracerebral and Subarachnoid Hemorrhage Research
- Ubiquitin and proteasome pathways
- Neuroendocrine Tumor Research Advances
- Erythrocyte Function and Pathophysiology
Wuhan No.1 Hospital
2021-2025
Weatherford College
2023
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
Xian Central Hospital
2023
Shanghai First Maternity and Infant Hospital
2020
Nanjing University of Chinese Medicine
2014-2019
Hubei University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2017
Dali University
2017
Damaged or dysfunctional mitochondria are toxic to the cell by producing reactive oxygen species and releasing death factors. Therefore, timely removal of these organelles is critical cellular homeostasis viability. Mitophagy mechanism selective degradation via autophagy. The significance mitophagy in kidney diseases, including ischemic acute injury (AKI), has yet be established, involved pathway remains poorly understood. Here, we show that induced renal proximal tubular cells both vitro...
SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays causal role in the development hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, mechanism by which signaling promotes metastasis remains to be clarified. Here, we reported that induced epithelial-mesenchymal transition (EMT) accelerating CDH1/E-cadherin lysosomal degradation facilitating HepG2 cells. Initially, found promoted cell migration EMT process decreasing expression...
The activation of autophagy has potential protective effect on diabetic nephropathy (DN) podocyte injury, and the AMPK/mTOR signaling pathway is an important regulatory autophagy. Emodin been reported to effectively delay DN progression; however, therapeutic mechanisms involved in vivo remain ambiguous. present study aimed elucidate mechanism emodin improving renal tissue injury by regulating AMPK/mTOR-autophagy pathway.All rats were divided into 4 groups: a Sham group, Vehicle low-dose...
Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, which risk factors mediate this unknown. Methods: intelligence (n=269,867), (n=510,795) cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals European ethnicities. genetic associations these (UK Biobank, n=397,867) analyzed using linkage...
Autophagy, a self-catabolic process, has been found to be involved in abrogating the proliferation and metastasis of breast cancer. SLC9A3R1 (solute carrier family 9, subfamily A [NHE3, cation proton antiporter 3], member 3 regulator 1), multifunctional scaffold protein, is suppressing cancer cells SLC9A3R1-related signaling pathway regulates activation autophagy processes. However, precise regulatory mechanism regulation processes remains unknown. Here, we report that stability BECN1, major...
Abstract In this study, daidzein long-circulating liposomes (DLCL) were prepared using the ultrasonication and lipid film-hydration method. The optimized preparation conditions by orthogonal design was as follows: 55 to 40 for molar ratio of soybean phosphatidylcholine (SPC) cholesterol, 1 10 mass total (SPC cholesterol) (w:w), indicated concentration 5% DSPE-mPEG2000 50 °C hydration temperature, 24 min ultrasonic time. Under these conditions, encapsulation efficiency drug loading DLCL 85.3...
The aim of the study was to assess relationship between procalcitonin (PCT) serum levels and acute ischemic stroke (AIS) in a Chinese sample. All consecutive patients with first-ever AIS January 2012 December 2013 were recruited participate study. PCT National Institutes Health Stroke Scale scores evaluated at time admission. Logistic regression analysis used evaluate risk for according levels. results indicated that significantly higher as compared normal controls (P<0.0001). increased...
ABSTRACT Inflammation is a significant risk factor and contributes to cardiovascular disease by driving both adaptive maladaptive processes. Macrophages are the most abundant immune cells in heart play an important role remodeling of cardiac tissue. We have previously shown overall protective function resident macrophages after pressure-overloaded injury. However, subpopulation also expresses high levels profibrotic CC motif chemokine ligand 24 (CCL24), suggesting dichotomous pressure...
Background Hepatitis B virus (HBV) x protein (HBx) in HepG2 cells causes a moderate decrease proteolysis activity of the proteasome. A highly conserved Kunitz-type serine protease inhibitor domain within 154 amino acid residues HBx has been identified. In this study, peptide chain derived from Kunitz (PKD) was used to study its effect on cell cycle and apoptosis cells, investigated function PKD activities proteasomes AAA-ATPase p97, which involves ubiquitin-proteasome degradation pathway....
The aim of this study was to construct and external validate a nomogram for predicting cardiogenic shock acute kidney injury (CS-AKI) in patients intensive care unit (ICU).