A5101780154- Neonatal Respiratory Health Research
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Medical Imaging and Pathology Studies
- Hereditary Neurological Disorders
- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Mesenchymal stem cell research
- NF-κB Signaling Pathways
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Autophagy in Disease and Therapy
- Breastfeeding Practices and Influences
- Rheumatoid Arthritis Research and Therapies
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Liver physiology and pathology
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Neurological diseases and metabolism
Cincinnati Children's Hospital Medical Center
2006-2024
First Affiliated Hospital of Anhui Medical University
2020-2024
Anhui Medical University
2020-2024
Jiangsu Hengrui Medicine (China)
2024
Urumqi General Hospital of PLA
2023
Peking University Third Hospital
2013-2023
National Health and Family Planning Commission
2019-2023
Peking University
2013-2023
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2023
Shandong First Medical University
2022
Preterm infants are often fed pasteurized donor milk or mother's that has been stored frozen for up to 4 weeks. Our objectives were assess the impact of pasteurization prolonged storage at -20 degrees C on immunologic components human and capability different forms support bacterial proliferation.The concentrations activities major host defense proteins in whey fractions weeks compared with freshly expressed milk. Proliferation bacteria incubated 3 was assessed.Relative milk, lysozyme,...
Abstract Macrophages are critical to organ structure and function in health disease. To determine mechanisms by which granulocyte/macrophage-colony stimulating factor (GM-CSF) signaling normally maintains surfactant homeostasis how its disruption causes pulmonary alveolar proteinosis (PAP), we evaluated lipid composition macrophages lung surfactant, macrophage-mediated clearance kinetics/dynamics, cholesterol-targeted pharmacotherapy of PAP vitro vivo . Without GM-CSF signaling,...
SOD1 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) in non-Caucasian patients. Detailed natural history profiles SOD1-mutant patients will be beneficial for strategy and interpretation future SOD1-targeted clinical practice. Mutational distribution, age at onset (AAO), site onset, diagnostic delay, disease progression (rate ALSFRS-R decrease, ΔFS) survival were analysed. Further comparisons between heredity disease, gender, performed. Sixty-six cases with 43...
Autophagy, a self-catabolic process, has been found to be involved in abrogating the proliferation and metastasis of breast cancer. SLC9A3R1 (solute carrier family 9, subfamily A [NHE3, cation proton antiporter 3], member 3 regulator 1), multifunctional scaffold protein, is suppressing cancer cells SLC9A3R1-related signaling pathway regulates activation autophagy processes. However, precise regulatory mechanism regulation processes remains unknown. Here, we report that stability BECN1, major...
Protein-containing polysaccharides extracted from fruiting bodies of a Chinese fungus named Feng Wei Gu, were fractionated and purified, their antitumor activities tested, out which the following active fractions obtained. FIo-a: A protein-containing xyloglucan, MW 280,000, polysaccharide: protein = 76:24 (w/w), polysaccharide consisting Man:Gal:Xyl:Glc 2:12:42:42 (molar ratio). [alpha]D23 + 25.3 degrees. FA-2: mannogalactan, 120,000, 76:16 Xyl:Man:Gal 9:35:56 ratio), 98.5 FII-1: xylan...
Abstract Liver fibrosis (LF) is the result of a vicious cycle between inflammation‐induced chronic hepatocyte injury and persistent activation hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)‐based therapy may represent potential remedy for treatment LF. However, fate transplanted MSCs in LF remains largely unknown. In present study, antifibrotic effect were explored model induced by CCl 4 mouse. Additionally, stimulated vitro with LF‐associated factors, tumor necrosis factor‐α...
Hereditary pulmonary alveolar proteinosis (PAP) is a genetic lung disease characterized by surfactant accumulation and respiratory failure arising from disruption of GM-CSF signaling. While mutations in either CSF2RA or CSF2RB (encoding receptor α β chains, respectively) can cause PAP, chain are responsible most patients. Pulmonary macrophage transplantation (PMT) promising new cell therapy development; however, no studies have evaluated this approach for hereditary PAP (hPAP) caused Csf2ra...
Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes ( CSF2RA/ CSF2RB, respectively) characterized impaired GM-CSF-dependent surfactant clearance macrophages (AMs) resulting accumulation and hypoxemic respiratory failure. Because hPAP CSF2RA most patients, we created an animal model of Csf2ra gene disruption –/– mice) evaluated the effects on AMs lungs. Macrophages from mice were unable to bind clear GM-CSF,...
To investigate whether wogonin, a key bioactive ingredient of Huangqi Guizhi formula (HQGZ formula; Traditional Chinese Medicine herbal formula) according to network pharmacology analysis, has analgesic effects on discogenic low back pain (LBP) via regulating the nerve growth factor (NGF) in intervertebral discs (IVDs).The lumbar IVDs rats were punctured LBP, and therapeutic effect orally administrated HQGZ for LBP was investigated by measuring mechanical cold allodynia histological...
Recently, a hexanucleotide repeat (GGGGCC) expansion in the chromosome 9 open reading frame 72 gene (C9orf72) was reported as major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal...
Background: Charcot-Marie-Tooth disease (CMT) is the most common inherited neurological disorder suffered in childhood. To date, features have not been extensively characterized Chinese paediatric population. In this study, we aimed to analyse clinical profiles and genetic distributions of a CMT cohort China. Methods: A total 181 patients were enrolled. After preexcluding PMP22 duplication/deletion by multiplex ligation-dependent probe amplification (MLPA), Sanger sequencing, targeted...
To explore the effects of pre-pregnancy body mass index (BMI), weight gain and blood lipid level during pregnancy on outcome in patients with without gestational diabetes mellitus(GDM). A total 12 650 singleton pregnant women history hypertension who were admitted at Women's Hospital, Zhejiang University School Medicine for delivery from January 2018 to April 2019 enrolled study. There 2381 cases complicated (GDM group) 10 269 GDM (non-GDM group). The BMI documented two groups. factors...
Introduction: Charcot-Marie-Tooth disease type 2A (CMT2A) is a group of clinically and genetically heterogeneous disorders, which mostly caused by mutations the mitofusin2 (MFN2) gene. As genotype-phenotype characteristics CMT2A were still incompletely understood, we further explored spectrum variants in China demonstrated their phenotypic diversities. Methods: A total 402 index patients/families with CMT throughout Mainland enrolled this study. Among them, analyzed 20 unrelated cases Sanger...
TUBA4A gene has recently been identified as a potential candidate amyotrophic lateral sclerosis(ALS)-associated using exome-wide rare variant burden analysis. The identification of novel variants in Italian ALS patients further support the role ALS. We sequenced coding region exon 4 cohort consisting 80 familial probands, 500 sporadic and healthy control individuals. No causative were patients. In conclusion, our current results did not find an association between Chinese patients, studies...
Abstract Background and purpose The Rasch‐Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) was developed using Rasch methodology. This scale has been demonstrated as a reliable outcome measure of amyotrophic lateral sclerosis (ALS) trials. To date, there are no similar interval‐weighted scales to assess disability in ALS patients. current study aimed validate Chinese version the ROADS via Methods obtained through standardized forward–backward translation cultural...
As tourette syndrome (TS) is a common neurobehavioral disorder, the primary symptoms of which include behavioral stereotypies. Dysfunction substantia nigra–striatum network could be main pathogenesis TS, closely associated with dopamine (DA) and its receptors. TS often resistant to conventional treatments. Therefore, it necessary investigate neurobiological mechanisms underlying pathogenesis. In this study, we investigated whether chemogenetic activation or inhibition dopaminergic D1...
Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its genetic polymorphisms ACE2 gene may promote cardiovascular systemic inflammatory injury COVID-19 patients. Hence, background potentially explain broad interindividual variation susceptibility and/or severity. Methods: Genetic to was analyzed by examining single-nucleotide (SNPs) 246 patients with 210 normal controls...