A5076830469- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Cancer therapeutics and mechanisms
- NF-κB Signaling Pathways
- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- DNA and Nucleic Acid Chemistry
- Mast cells and histamine
- Quinazolinone synthesis and applications
- Eosinophilic Disorders and Syndromes
- ATP Synthase and ATPases Research
- Traditional Chinese Medicine Analysis
- Pain Mechanisms and Treatments
- interferon and immune responses
- Asthma and respiratory diseases
- Pain Management and Opioid Use
- Natural Compounds in Disease Treatment
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Macrophage Migration Inhibitory Factor
- Phytochemistry and Biological Activities
University of Colombo
2016-2024
China Pharmaceutical University
2013-2015
Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer pain. Spinal glial cells play critical role in maintenance of by releasing proinflammatory cytokines and chemokines. In this study, we verified the levo-corydalmine (l-CDL) on TCIP. Methods: Spontaneous pain, paw withdrawal threshold latency were assessed using TCIP mouse model. Immunofluorescence was used to identify reactions glia. RT-PCR western blot or ELISA determine mRNA protein expression tumor necrosis...
Mitochondria-mediated cardiomyocyte apoptosis is involved in myocardial ischemia/reperfusion (MI/R) injury. Clematichinenoside (AR) a triterpenoid saponin isolated from the roots of Clematis chinensis with antioxidant and anti-inflammatory cardioprotection effects against MI/R injury, yet anti-apoptotic effect underlying mechanisms AR injury remain unclear. We hypothesize that may improve mitochondrial function to inhibit MI/R-induced apoptosis. In this study, we replicated an vitro H9c2...
Triptolide (TP) has been confirmed to possess many beneficial functions including anti-inflammation and immunosuppression.