A5101582064- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Cardiac electrophysiology and arrhythmias
- Immune cells in cancer
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Microbial Metabolic Engineering and Bioproduction
- COVID-19 diagnosis using AI
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Advanced Thermoelectric Materials and Devices
- Artificial Intelligence in Healthcare and Education
- Exercise and Physiological Responses
- Inflammation biomarkers and pathways
- Machine Learning in Healthcare
- IL-33, ST2, and ILC Pathways
- Vitamin C and Antioxidants Research
- Advanced Thermodynamics and Statistical Mechanics
- Cardiomyopathy and Myosin Studies
- Stock Market Forecasting Methods
- Genetics and Physical Performance
University of Minnesota
2020-2024
University of Minnesota Medical Center
2021-2024
Health Net
2023
University of Minnesota System
2023
National Institute of Technology Tiruchirappalli
2016
The initial hypertrophy response to cardiac pressure overload is considered compensatory, but with sustained stress, it eventually leads heart failure. Recently, a role for recruited macrophages in determining the transition from compensated decompensated has been established. However, whether resident immune cells influence early phase of development not established.To assess induced by transverse aortic constriction (TAC).We performed cytometry time-of-flight determine identity and...
Background and Aims Nonalcoholic steatohepatitis is rapidly becoming the leading cause of liver failure indication for transplantation. Hepatic inflammation a key feature NASH but immune pathways involved in this process are poorly understood. B lymphocytes cells adaptive system that critical regulators responses. However, role pathogenesis potential mechanisms to their activation unclear. Approach Results In study, we report livers accumulate with elevated pro‐inflammatory cytokine...
Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of pathology ranging from simple to non-alcoholic steatohepatitis (NASH). Notably, immune cell-driven inflammation is key mechanism in the transition more serious NASH. Although exercise training effective ameliorating obesity-related diseases, underlying mechanisms beneficial effects remain unclear. It unknown whether there an optimal modality and intensity treat NAFLD. The objective this study was determine high-intensity...
For patients with obesity and metabolic syndrome, bariatric procedures such as vertical sleeve gastrectomy (VSG) have a clear benefit in ameliorating dysfunction-associated steatohepatitis (MASH). While the effects of surgeries been mainly attributed to nutrient restriction malabsorption, whether immuno-modulatory mechanisms are involved remains unclear. Using murine models, we report that VSG ameliorates MASH progression weight loss-independent manner. Single-cell RNA sequencing revealed...
Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation the unfolded protein response (UPR), and reductions in multiple cardiac ion channels. When activated, kinase–like ER kinase (PERK) branch UPR reduces translation abundance. We hypothesized that PERK inhibition could prevent channel downregulation reduce arrhythmia after myocardial infarct (MI). MI induced mice by coronary artery ligation resulted reduced levels, ventricular tachycardia (VT), prolonged...
ABSTRACT Inflammation is a significant risk factor and contributes to cardiovascular disease by driving both adaptive maladaptive processes. Macrophages are the most abundant immune cells in heart play an important role remodeling of cardiac tissue. We have previously shown overall protective function resident macrophages after pressure-overloaded injury. However, subpopulation also expresses high levels profibrotic CC motif chemokine ligand 24 (CCL24), suggesting dichotomous pressure...
For patients with obesity and metabolic syndrome, bariatric procedures such as vertical sleeve gastrectomy (VSG) have a clear benefit in ameliorating dysfunction-associated steatohepatitis (MASH). While the effects of surgeries been mainly attributed to nutrient restriction malabsorption, whether immuno-modulatory mechanisms are involved remains unclear. Here we report that VSG ameliorates MASH progression weight loss-independent manner. Single-cell RNA sequencing revealed hepatic...
Catheter ablation is associated with limited success rates in patients persistent atrial fibrillation (AF). Currently, existing mapping systems fail to identify critical target sites for ablation. Recently, we proposed and validated several techniques (multiscale frequency [MSF], Shannon entropy [SE], kurtosis [Kt], multiscale [MSE]) pivot point of rotors using ex-vivo optical animal experiments. However, the performance these unclear clinically recorded intracardiac electrograms (EGMs), due...
Thermoelectric materials are gaining growing focus in areas of alternate energy due to their ability efficient conversion from heat electrical energy. In this paper we discuss the scope such relevance converting waste dissipation laptop useful form for charging low power devices (Mobile phones). broad will be discussing how changing thermoelectric release burden on depleting resources like coal and oil, would help lower global temperature.
ABSTRACT Nonalcoholic steatohepatitis (NASH), characterized by hepatic inflammation and cellular damage, is the most severe form of nonalcoholic fatty liver disease fastest-growing indication for a transplant. The intestinal immune system central modulator local systemic inflammation. In particular, Peyer’s patches (PPs) contain T follicular helper (Tfh) cells that support germinal center (GC) responses required generation high-affinity IgA maintenance homeostasis. However, our understanding...
In the realm of healthcare, integration Deep Learning (DL) stands as a potent force, propelling advancements in medical diagnosis and treatment. This paper navigates recent strides, persistent hurdles, emerging applications within this synergy. DL basics are elucidated initially, demonstrating neural networks' role data analysis. Progressing further, we unveil DL's robust diagnosis, particularly via Convolutional Neural Networks, revolutionizing image-based disease detection. Yet, frontier...
Cardiac alternans, beat-to-beat alternations in action potential duration, is a precursor to fatal arrhythmias such as ventricular fibrillation. Previous research has shown that voltage driven alternans can be suppressed by application of constant diastolic interval (DI) pacing protocol. However, the effect constant-DI on cardiac cell dynamics and its interaction with intracellular calcium cycle remains determined. Therefore, we aimed examine effects dynamical behavior single-cell numerical...
ABSTRACT For patients with obesity and metabolic syndrome, bariatric procedures such as vertical sleeve gastrectomy (VSG) have a clear benefit in ameliorating dysfunction-associated steatohepatitis (MASH). While the effects of surgeries been mainly attributed to nutrient restriction malabsorption, whether immuno-modulatory mechanisms are involved remains unclear. Here we report that VSG ameliorates MASH progression weight loss- independent manner. Single-cell RNA sequencing revealed hepatic...
Abstract The intestinal immune system is a central modulator of obesity-associated metabolic disease. Particularly, high-affinity IgA maintains gut homeostasis after its generation in germinal center (GC) response that requires functional T follicular helper (Tfh) cells Peyer’s patches (PP). objective this study was to determine how obesity affects Tfh function leading We investigated the phenotype diet-induced obese mice. Obese mice showed enlarged PP featured by an expansion CXCR5 highICOS...
ABSTRACT B cells play a crucial role in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH), severe form steatotic liver disease that if persistent can lead to cirrhosis, failure, and cancer. Chronic inflammation fibrosis are key features MASH determine progression outcomes. Recent advances have revealed pathogenic cell-derived cytokines antibodies promote development MASH. However, mechanisms through which adaptations underlying their responses remain unclear. Here,...
In response to cardiac injury or increased workload, the mammalian heart undergoes ventricular remodeling maintain function. Initally, these changes are compensatory, although ultimately, they can lead death of cardiomyocytes, dilation, and progression failure. It is critical understand underlying mechanisms that regulate this transition, since it could identify new therapeutic targets. The role small GTPase Septin4 in heart, regulating stress unknown. Previous research has implicated Septin...
Background: Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation the unfolded protein response (UPR), and reductions in multiple cardiac ion channels transporters. When activated, kinase-like ER kinase (PERK) arm (UPR) reduces translation abundance. We hypothesize that inhibition PERK could prevent channel downregulation reduce arrhythmic after myocardial infarct (MI). Methods: The MI mouse model was induced by a left anterior descending coronary artery...
Heart failure (HF) is the leading cause of death worldwide. Systemic inflammation associated with HF and considered an independent predictor adverse cardiac outcomes. Macrophages are most abundant immune cells in heart have integral roles homeostasis remodeling. Despite their unique identity homeostatic functions, precise role macrophages during remodeling poorly understood. We previously reported that resident expand early response to pressure overload injury provide cardioprotection. Using...
Cardiac hypertrophy is the abnormal enlargement of myocardium in response to stress and injury. Previous studies have largely focused on role cardiomyocyte-intrinsic mechanisms regulating hypertrophic injury transition heart failure, with a recent shift focus other cardiac cell types, including immune cells. Since fibrosis hallmark feature pathological key contributor decreased ventricular performance during pressure overload, it important investigate how regulated macrophages contribute...
Introduction: In response to cardiac injury or increased workload, the mammalian heart undergoes ventricular remodeling maintain function. Initially, these changes are compensatory, although ultimately, they lead cardiomyocyte death and progression failure. As one of aspects remodeling, fibrosis significantly reduces To identify potential new therapeutic targets, it is essential understand underlying mechanisms that regulate fibrosis. Previous research highlighted a possible interplay...