A5035103607- Dermatology and Skin Diseases
- Inflammatory mediators and NSAID effects
- Seaweed-derived Bioactive Compounds
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Pharmacological Effects of Natural Compounds
- Advanced Glycation End Products research
- RNA modifications and cancer
- Skin and Cellular Biology Research
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Cardiac electrophysiology and arrhythmias
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Urticaria and Related Conditions
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
University of Minnesota
2018-2025
Minneapolis Heart Institute Foundation
2018-2024
Dongguk University
2014-2019
Jeju National University
2007-2018
National Cancer Center
2018
Institute of Cardiology
2006-2009
Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in immune response preventing or suppressing differentiation, proliferation function various cells, including CD4+ cells. Recent studies report that fermentation has a tremendous capacity to transform chemical structures create new substances, omega-3 polyunsaturated fatty acids (n-3 PUFAs)...
Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from Ishige okamuarae, brown alga. This study was conducted to investigate the anti-inflammatory effect and action mechanism of DPHC in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. We found that strongly reduces production interleukin 6 (IL-6), but not tumor necrosis factor-alpha (TNF-α) induced by LPS. (12.5 100 μM) suppressed phosphorylation nuclear translocation NF-kappaB (NF-κB), central signaling...
Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these are changed during maturation and immature is known to larger amounts than mature. Chemokines significant mediators for cell migration, while thymus activation-regulated chemokine (TARC/CCL17) macrophage-derived (MDC/CCL22) well as typical inflammatory chemokines in atopic dermatitis (AD), a pruritic chronic skin disease. We reported recently EtOH extract unshiu inhibits TARC MDC...
Here, we investigated whether over-activation of AKT pathway is important in the resistance to 5-fluorouracil (5-FU) SNU-C5/5-FU cells, 5-FU-resistant human colon cancer cells. When compared wild type SNU-C5 cells (WT), showed PI3K/AKT pathway, like increased phosphorylation AKT, mTOR, and GSK-3β, nuclear localization β-catenin, decreased E-cadherin. Moreover, E-cadherin level was down-regulated recurrent tissues primary tissues. Gene silencing AKT1 or treatment LY294002 (PI3 kinase...
Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation the unfolded protein response (UPR), and reductions in multiple cardiac ion channels. When activated, kinase–like ER kinase (PERK) branch UPR reduces translation abundance. We hypothesized that PERK inhibition could prevent channel downregulation reduce arrhythmia after myocardial infarct (MI). MI induced mice by coronary artery ligation resulted reduced levels, ventricular tachycardia (VT), prolonged...
Pancreatic cancer is the fourth leading cause of cancer-related deaths. Epithelial-mesenchymal transition (EMT) drives aggressive behaviour and unfavourable outcomes in this disease. The zinc finger E-box-binding homeobox 1 (ZEB1) transcription factor pivotal orchestrating EMT, promoting tumor cell mobility, metastasis, immune evasion through phosphorylation events. However, precise mechanisms underlying individual sites their relationship with ZEB1's functions vivo remain inadequately...
Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls movement monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum skin MDC/CCL22 levels are elevated in atopic dermatitis, which suggests produced from keratinocytes responsible for attracting lymphocytes to skin. A major signaling pathway interferon-γ (IFN-γ)-stimulated inflammation response involves signal transducers activators transcription 1 (STAT1)....
Nitric oxide (NO) is a crucial molecule in inflammatory diseases and synthesized from L-arginine by specific enzyme, NO synthase (NOS). The expression of inducible NOS (iNOS) activated macrophages various stimuli, such as lipopolysaccharide (LPS), wall component gram-negative bacteria. LPS binds to toll-like receptor 4 (TLR4) on the macrophage surface activates several downstream signaling pathways, including mitogen-activated protein kinase (MAPK) nuclear factor (NF)-κB pathways. This study...
Abstract Triple‐negative breast cancer (TNBC) is associated with a high mortality rate, which related to the insufficient number of appropriate biomarkers and targets. Therefore, there an urgent need discover targets for TNBC. SARNP (Hcc‐1 CIP29) highly expressed in several cancers. It binds UAP56, RNA helicase component TREX complex messenger (mRNA) splicing export. However, role mRNA export progression cancer, especially TNBC, remains unknown. we examined We confirmed that UAP56 Aly...
Cardiac ischemia is associated with arrhythmias; however, effective therapies are currently limited. The cardiac voltage-gated sodium channel α subunit (SCN5A), encoding the Nav1.5 current, plays a key role in electrical conduction and arrhythmic risk. Here, we show that hypoxia reduces through effects on miR, miR-448. miR-448 expression increased ischemic cardiomyopathy. has conserved binding site 3′-UTR of SCN5A. to this suppressed SCN5A currents. Hypoxia-induced HIF-1α NF-κB were major...
ARG2 has been reported to inhibit autophagy in vascular endothelial cells and keratinocytes. However, studies of its mechanism action, role skin fibroblasts, the possibility promoting inhibiting cellular senescence through inhibition are lacking. We induced dermal fibroblasts by using H2O2. H2O2-induced fibroblast was inhibited upon knockdown promoted overexpression. The microRNA miR-1299 suppressed expression, thereby senescence, inhibitors upregulating ARG2. Using yeast two-hybrid assay,...
Inflammatory chemokines, such as macrophage-derived chemokine (MDC/CCL22), are elevated in the serum and lesioned skin of patients with atopic dermatitis (AD), ligands for C-C receptor 4, which is predominantly expressed on T helper 2 lymphocytes, basophils natural killer cells. We have previously reported that quercetagetin has an inhibitory activity inflammatory induced by interferon (IFN)-γ tumour necrosis factor (TNF)-α, occurring via inhibition signal transducer activator transcription...