A5017010127- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Digital Marketing and Social Media
- Cancer, Stress, Anesthesia, and Immune Response
- Caveolin-1 and cellular processes
- Telomeres, Telomerase, and Senescence
- Pharmacogenetics and Drug Metabolism
- Quinazolinone synthesis and applications
- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Neuropeptides and Animal Physiology
- PARP inhibition in cancer therapy
- Body Contouring and Surgery
- Axon Guidance and Neuronal Signaling
- Membrane Separation and Gas Transport
- Diverse Aspects of Tourism Research
- scientometrics and bibliometrics research
- Erythropoietin and Anemia Treatment
- Bioactive Compounds and Antitumor Agents
- Abdominal Surgery and Complications
Dongguk University
2019-2025
Bạch Mai Hospital
2022-2023
Cho Ray Hospital
2020
Hanoi University of Pharmacy
2017
Woolcock Institute of Medical Research
2016
Y-box binding protein 1 (YBX1), a member of the Cold Shock Domain family, is overexpressed in various human cancers and recognized as an oncogenic gene associated with poor prognosis. YBX1’s functional diversity arises from its capacity to interact broad range DNA RNA molecules, implicating involvement diverse cellular processes. Independent investigations have unveiled specific facets contribution cancer development. This comprehensive review elucidates multifaceted role across hallmarks,...
Pancreatic cancer is the fourth leading cause of cancer-related deaths. Epithelial-mesenchymal transition (EMT) drives aggressive behaviour and unfavourable outcomes in this disease. The zinc finger E-box-binding homeobox 1 (ZEB1) transcription factor pivotal orchestrating EMT, promoting tumor cell mobility, metastasis, immune evasion through phosphorylation events. However, precise mechanisms underlying individual sites their relationship with ZEB1's functions vivo remain inadequately...
ARG2 has been reported to inhibit autophagy in vascular endothelial cells and keratinocytes. However, studies of its mechanism action, role skin fibroblasts, the possibility promoting inhibiting cellular senescence through inhibition are lacking. We induced dermal fibroblasts by using H2O2. H2O2-induced fibroblast was inhibited upon knockdown promoted overexpression. The microRNA miR-1299 suppressed expression, thereby senescence, inhibitors upregulating ARG2. Using yeast two-hybrid assay,...
Madelung disease is a rare condition of unknown etiology, characterized by large masses subcutaneous fat in the upper body bilaterally. It rarely affects lower extremities and genital region.Here, we report patient with Donhouser's type III Madelung's disease. A 47-year-old male presented giant fatty scrotal tumor that caused deformation scrotum penis, made it difficult to perform daily activities, hindered sexual activity. The adipose was completely removed using midline incision....
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis associated with epithelial-mesenchymal (EMT). However, the specific signals that induce regulate EMT in carcinoma cells remain unclear. PRR16/Largen cell size regulator independent mTOR Hippo signalling pathways. little known about role PRR16 plays process. We found expression was increased mesenchymal lines. overexpression induced MCF7 enhances migration invasion....
LW1497 suppresses the expression of hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, has not been therapeutically applied cancer yet. Thus, we investigated effect on epithelial-mesenchymal transition (EMT) lung cells. A549 H1299 cells were induced undergo via TGF-β1 treatment, resulting downregulation E-cadherin upregulation N-cadherin Vimentin concurrently with increases migration invasion capacities These...
Community-wide active case finding for tuberculosis (TB) using Xpert® MTB/RIF as the primary screening tool, Ca Mau Province, Viet Nam.To determine whether macroscopic sputum quality characteristics (sputum colour and volume) can be used to predict Xpert MTB-negative hence exclude samples from testing.Field staff conducted household visits approximately 51,200 adults in 58 villages randomly selected throughout province. Sputum all screened participants who were able produce ⩾1 ml underwent...
Melanogenesis is the production of melanin from tyrosine by a series enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The content skin determines pigmentation. Abnormalities pigmentation lead to various disorders. Recent research has shown that expression EMP2 much lower melanoma than normal melanocytes, but its role melanogenesis not yet been elucidated. Therefore, we investigated MNT1 human cells. We examined TRP-1, TRP-2, TYR levels during cells gene...
Ras homolog enriched in brain (Rheb1 and Rheb2), a small GTPase, regulates neuronal activity has drawn attention for its implications cancer development, especially breast cancer. This study explores the multifaceted role of Rheb1 cancer, elucidating involvement crucial cel-lular processes such as proliferation, apoptosis resistance, migration, invasion, metastasis, inflammatory responses. Despite these acknowledged connections, comprehensive understanding intricate interplay between remains...
Ras homolog enriched in brain (Rheb1 and Rheb2), small GTPases, play a crucial role regulating neuronal activity have gained attention for their implications cancer development, particularly breast cancer. This study delves into the intricate connection between multifaceted functions of Rheb1 neurons cancer, with specific focus on mTOR pathway. It aims to elucidate Rheb1’s involvement pivotal cellular processes such as proliferation, apoptosis resistance, migration, invasion, metastasis,...
ABSTRACT Introduction: Acute cholecystitis due to gallstone disease during pregnancy often requires emergency surgical treatment. Laparoscopic cholecystectomy (LC) can be performed concurrently with cesarean section when management delayed until after birth. Case presentation: A 25-year-old female patient was 38 weeks pregnant. On day five, she taken the hospital treat cholecystitis. We surgery in collaboration obstetrician and gastrointestinal team. healthy baby weighing 3200 g born an...