A5031147987- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Research in Cotton Cultivation
- Protein Degradation and Inhibitors
- Ginger and Zingiberaceae research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- DNA and Nucleic Acid Chemistry
- Synthesis and bioactivity of alkaloids
- Steroid Chemistry and Biochemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hormonal Regulation and Hypertension
- Fluid Dynamics and Thin Films
- Fungal Plant Pathogen Control
- Polymer-Based Agricultural Enhancements
- Fungal Infections and Studies
Hanoi University of Science and Technology
2016-2025
Hanoi University of Business and Technology
2024
Pohang University of Science and Technology
2005-2010
Institute of Mathematics
2005
The alkylation reaction was used to couple zerumbone with the 3-substituted quinazolinone-4(3H)-ones and quinolines, resulting in formation of 11 new conjugates. Their structures were fully characterized by 1D-, 2D-NMR, HRMS spectral data. evaluation their anti-inflammatory activity examined inhibiting NO production RAW 267.4 cells. Screening for cytotoxic performed using three human cancer cell lines HepG2, SK-LU-1, MCF-7. results indicated that all novel conjugates exhibited potent against...
Abstract In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized a series of N ‐hydroxyheptanamides incorporating 7‐hydroxy‐2‐oxo‐2 H ‐chromene‐3‐carboxamides ( 6a‐o ). Biological evaluation showed that these hydroxamic acids were generally cytotoxic against five human cancer cell lines including A549 (human lung carcinoma), DD1 colon adenocarcinoma), Huh‐7 hepatocellular NCCIT embryonic H23 (adenocarcinoma; non‐small cancer) normal line Vero....
A series of novel 5′(7′)-substituted-2′-oxospiro[1,3]dioxolane-2,3′-indoline-based N-hydroxypropenamides were designed, synthesized and evaluated for histone deacetylase (HDAC) inhibition cytotoxicity. It was found that the compounds in this displayed potent inhibitory effects against HDAC2 with IC50 values as low 0.284 μM, almost comparable to SAHA (IC50, 0.265 μM), a positive control. In Western blot analysis, these also exhibited noted toward deacetylation correlate well cytotoxicity...
This paper describes an investigation on the dynamic behavior of droplet formation in a microfluidic flow-focusing device (MFFD) under effect surfactant using phase-field method and Koterweg stress applied Navier–Stokes equations. The effects variously important parameters, such as capillary number (Ca0), water fraction (wf), viscosity ratio (α), particularly concentration (cb), were examined. Consequently, numerical results match experimental ones. Additionally, is significantly affected by...
A series of novel quinolinylhydrazones (5a-f) was synthesized by the condensation reaction 2,6-diarylsubstituted piperidin-4-ones (4a-f) with 7-chloro-4-hydrazinoquinoline (2). Novel containing Shiff bases 8a-f and 11a-f were obtained via 7a-f 10a-f 7-chloro-4-hydrazinoquinoline. These hydrazones screened for their in vitro antimalarial activities to chloroquine - sensitive (T96) – resistant (K1) strains P.falciparum. Among compounds, 11a exhibited strong activity at IC50 103.4 ng/mL 18.76...
A series of Novel Mannich bases has been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), lung (SK-LU-1), breast cancer (MCF-7). Compound 9f was found to be most potent three cell lines with IC50 values 1.57, 1.16 1.21 µg/mL, respectively. In addition, compounds 9g, 10f exhibited very significant MCF-7 line 2.0 µg/mL.
Abstract: A two-step procedure was applied to couple zerumbone, a natural sesquiterpene, with thiols 8a-k obtain small library of ten novel zerumbone derivatives 9a-k full-length data spectra including 1H-, 13C-NMR, and HRMS. The tautomerization 9a, 9b, 9c revealed in DMSO discussed the case 9c. series together 1 evaluated for their vitro cytotoxic activity using three human cancer cell lines, HepG2, A549 HeLa. results that all had against A549, HeLa cells 4-20 times stronger than zerumbone.
A series of 14 new (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mo>-</mml:mo></mml:mrow></mml:math>)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays several exhibited cytotoxic effects against three human cancer cell lines. Compound 8a greatest effect hepatocellular carcinoma (HepG2), lung (LU-1), breast (MCF-7) lines...
Background: Target-based approach to drug discovery currently attracts a great deal of interest from medicinal chemists in anticancer and development worldwide, Histone Deacetylase (HDAC) inhibitors represent an extensive class targeted anti-cancer agents. Among the most explored structure moieties, hydroxybenzamides hydroxypropenamides have been demonstrated potential HDAC inhibitory effects. Several compounds these structural classes approved for clinical uses treat different types cancer,...
Abstract Phospholipids and liposomes have been the subjects of considerable attention because their importance in biological systems. We efficiently synthesized novel nucleoside‐based phospholipids six‐step sequences starting from corresponding nucleosides. These self‐assemble into liposome‐like structures aqueous solutions. analyzed these by dynamic light scattering, transmission electron microscopy, confocal microscopy.
The target-based approach to drug discovery currently attracts a great deal of interest from medicinal chemists in anticancer and development. Histone deacetylase (HDAC) inhibitors represent an extensive class targeted anti-cancer agents. Among the most explored structure moieties, hydroxybenzamides hydroxypropenamides have been demonstrated potential HDAC inhibitory effects. Several compounds these structural classes approved for clinical uses treat different types cancer, such as...
CuSO4/hydrazine hydrate was used as a catalyst system for copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) of AZT and 5′-azido adenosine with terminal alkynes to give 30 novel 1,2,3-triazole derivatives. Screening their anticancer, anti-inflammatory, angiotensin-converting enzyme 2 (ACE2), 3C-like protease (3CLpro) inhibitory activities showed that several triazoles containing murayafoline A indirubin-3′-oxime inhibited the growth HepG2 LU-1 IC50 values ranging from 11.01 19.87 μg/mL....
In this paper, we report the syn-thesis of cytidine-, guanosine-based phosphocholines having saturated acyl chain at 2'-, 3'- position nucleosides as shown in Figure 1.The synthetic scheme that have used for synthesis nucleoside-based phospholipids is Scheme 1 and 2. We protecting groups such
Background: Direct N-alkylation of murrayafoline A (1) by epichlorohydrin, followed the opening 3-(1-methoxy-3-methyl-N-carbazolyl)-1,2-epoxypropane (2) with aliphatic and heterocyclic amines catalyzed Zn(HClO4)2 .6H2O in mild condition led to formation thirteen β-amino alcohols (6a-n) moderate yields. In vitro anticancer activity these was evaluated against four human cancer cell lines including Hep-G2, LU-1, P 338 SW 480 comparison A. The results showed that synthesized (excluding 6e,...
The paper presents a simple synthesis of new quinazolinone derivatives 13a-i. Synthesized were tested for their cytotoxic effect against three cancer cell lines including SKLU-1, MCF-7 and HepG-2. bioassay result showed that only compound 13e exhibited significant with IC50 values 9.48, 20.39 18.04 µg/ mL, respectively.