A5073961077- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Quinazolinone synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Natural Antidiabetic Agents Studies
- Enzyme Catalysis and Immobilization
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical synthesis and alkaloids
- Phytochemicals and Antioxidant Activities
- Synthetic Organic Chemistry Methods
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Oxidative Organic Chemistry Reactions
- Alkaloids: synthesis and pharmacology
- Ginger and Zingiberaceae research
- Chemical Synthesis and Reactions
- Vibrio bacteria research studies
- Fungal Plant Pathogen Control
- Microencapsulation and Drying Processes
- Biochemical and biochemical processes
- Synthesis and biological activity
- Bacterial Identification and Susceptibility Testing
- Plant Gene Expression Analysis
Vietnam National University Ho Chi Minh City
2020-2025
Cho Ray Hospital
2025
Ho Chi Minh City International University
2020-2024
Vietnamese-German University
2024
International University
2019-2020
The University of Texas Southwestern Medical Center
2017
University of Houston
2012-2016
A hydrazone-based carbene/alkyne cascade produced a variety of bridged and fused polycyclic products. NaOSiMe3 is superior base for conversion hydrazones to diazoalkanes. key mechanistic intermediate, ring-fused cyclopropene, has been isolated characterized.
The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key enable general reaction. High yields and useful er's observed for host common heteroaryls.
Six lines or varieties of cassava, including three potential (HL-KM94, HL-S14, KM505-54) and resistance to the Sri Lanka cassava mosaic virus (SLCMV) (HN1, HN5, HN97), were evaluated in 2022 Quang Binh province. The aim this study was select lines/varieties with high yield, starch content SLCMV disease, suitable for local conditions. experiment designed a randomized complete block design (RCBD), 3 replications. research results showed that used had an average germination time 16.7 - 22.0...
<title>Abstract</title> <bold>Purpose</bold> The increase in carbapenem-resistant Enterobacterales (CRE) strains has shown significant variations over time and geographical regions. types of Carbapenemase-producing genes CRE Southern Vietnam have not yet been completely known; therefore, this study provides knowledge the epidemiology compares findings with global strains.<bold>Methods</bold> This utilizes whole-genome sequencing to analyze 195 from patients at Cho Ray Hospital, a major...
Microalgae from the Chlorophyta group have garnered attention for their potential as sustainable sources of bioactive compounds applicable in food, biostimulant and pharmaceutical sectors. This investigation focused on Chlorella sorokiniana Scenedesmus quadricauda, both isolated Ca Cam River Ho Chi Minh City, Vietnam. The main objectives were to extract characterize chlorophyll a b, carotenoids phycocyanin evaluate total antioxidant capacity. Ultrasound treatment was used disrupt microalgal...
Nghiên cứu được thực hiện nhằm khảo sát hàm lượng polyphenol và flavonoid, hoạt tính kháng oxy hóa, cùng khả năng ức chế α-glucosidase của hoa, lá thân cây sao nhái tím (Cosmos bipinnatus) khi sử dụng hai dung môi chiết xuất khác nhau là ethanol 96% 50%. Kết quả cho thấy 50% hiệu hơn trong việc polyphenol, lại thu nhiều flavonoid hơn. Trong đó, hoa có cao nhất, tiếp theo thân. Các từ cũng thể hóa mạnh đánh giá thông qua trị IC50 các thử nghiệm DPPH (từ 24,78 đến 28,62 µg/mL) lực RP 0,34 0,36...
A highly efficient method for the direct construction of amide bonds via a selective cleavage C–H and CC in indole structures using an iodine-promoted approach was developed.
A novel synthesis of furocoumarins was developed by a reaction between oxime esters and 4-hydroxycoumarins. The proposed to undergo radical mechanism mediated iodine, cheap common laboratory reagent. Mechanistic studies showed the key for successful transformation presence α-iodoimine intermediate which facilitated ring-closing step. conditions produced good functional group tolerance with wide range high-profile furocoumarin product. potential this strategy be applied in other syntheses...
This account chronicles the iterative development of an enantioselective conjugate addition organoboron nucleophiles to α,β-unsaturated enones and enals catalyzed by BINOL derivatives. Beginning with a specific application this transformation total synthesis flinderole alkaloids, progressed encompass much larger scope heterocycle-substituted electrophiles. The next phase saw progress toward use broader functional nucleophiles, in strategy synthesize discoipyrrole D. At each stage...
CuSO4/hydrazine hydrate was used as a catalyst system for copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) of AZT and 5′-azido adenosine with terminal alkynes to give 30 novel 1,2,3-triazole derivatives. Screening their anticancer, anti-inflammatory, angiotensin-converting enzyme 2 (ACE2), 3C-like protease (3CLpro) inhibitory activities showed that several triazoles containing murayafoline A indirubin-3′-oxime inhibited the growth HepG2 LU-1 IC50 values ranging from 11.01 19.87 μg/mL....
A computational NMR approach for accurate predicting the 1 H/ 13 C chemical shifts of triterpenoid oximes featuring screening 144 DFT methods was demonstrated.
Boesenbergia pandurata (Roxb.) Schltr. is a perennial medicinal herb belonging to the Zingiberaceae family. It cultivated in some tropical countries Southeast Asia including Vietnam, Thailand, Myanmar, Indonesia and Malaysia. In it known as "Ngai bun", fresh rhizomes are mainly used spice. This plant contains prenylated chalcones other flavonoids major bioactive constituents. From CHCl3 extract of pandurata, we had isolated six flavanones. Their structures, pinocembrin (1), pinostrobin (2),...
Abstract A general approach for the synthesis of bridged polycyclic compounds based on a cascade reaction initiated by rhodium carbene formation is assembled.
Complex polycyclic natural products present daunting challenges to the synthetic organic chemist and thus drive innovation. We have been inspired by presented chiral indole alkaloid bridged products. new experimental results for enantioselective conjugate additions generate alpha-chiral heterocycles carbene cascade reactions functionalized bicycles. also show application of these methods total synthesis
Abstract A variety of bridged, caged, and fused polycyclic systems is obtained from hydrazones by a cascade reaction sequence involving hydrazone decomposition, dediazotization, cyclopropanation, carbene generation, C—H bond insertion using NaOTms rhodium catalyst.