A5078791721- Cardiac Fibrosis and Remodeling
- Endoplasmic Reticulum Stress and Disease
- Microbial Inactivation Methods
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Gut microbiota and health
- Biochemical effects in animals
- Cardiac Imaging and Diagnostics
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
University of Minnesota
2024
Minneapolis Heart Institute Foundation
2024
Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The mechanisms underlying DM-associated AF are unclear. and DM both related to inflammation. We investigated whether inflammation contributed risk. Mice were fed with high-fat diet induce type II subjected IL-1β antibodies, macrophage depletion by clodronate liposomes, a mitochondrial antioxidant (mitoTEMPO), or cardiac ryanodine receptor 2 (RyR2) stabilizer (S107). All tests performed at 36-38 weeks of age....
This study aims to investigate the effect of probiotic Lactobacillus paracasei N1115 on Type 2 diabetes mellitus (T2DM) rats. SD rats were randomly divided into 5 groups, including control group (ND), (DM) group, and high (10 9 CFU/mL), medium 8 or low 7 CFU/mL) doses probiotics intervention groups. The ND fed a normal diet, others high‐fat diet injected with streptozotocin (STZ) build T2DM model. In three given high, medium, L. by gavage for 12 weeks. Results indicated that could prevent...
Ischemic cardiomyopathy is associated with an increased risk of sudden death, activation the unfolded protein response (UPR), and reductions in multiple cardiac ion channels. When activated, kinase–like ER kinase (PERK) branch UPR reduces translation abundance. We hypothesized that PERK inhibition could prevent channel downregulation reduce arrhythmia after myocardial infarct (MI). MI induced mice by coronary artery ligation resulted reduced levels, ventricular tachycardia (VT), prolonged...
Increased mitochondrial Ca