A5074787754- Virology and Viral Diseases
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Geological and Geophysical Studies
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Vector-Borne Animal Diseases
- Thyroid Disorders and Treatments
- Animal Disease Management and Epidemiology
- Soybean genetics and cultivation
- Acute Ischemic Stroke Management
- Tuberculosis Research and Epidemiology
- Nanoparticle-Based Drug Delivery
- Geological formations and processes
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Methane Hydrates and Related Phenomena
- Epilepsy research and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Prenatal Screening and Diagnostics
- Medical Imaging Techniques and Applications
Guangxi University
2019-2025
Huazhong University of Science and Technology
2025
Union Hospital
2025
Fujian Academy of Agricultural Sciences
2024
China Medical University
2014-2024
First Hospital of China Medical University
2019-2024
Shandong First Medical University
2024
Guangxi University of Chinese Medicine
2024
Affiliated Hospital of Jining Medical University
2024
Shandong Provincial Hospital
2024
Inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are poorly understood disorders affecting the intestinal tract.The current model for suggests that genetically susceptible patients develop intolerance to gut microflora, chronic inflammation develops as a result of environmental insults.Although interest has mainly focused on studying genetic variants bacterial flora, little is known about potential viral infection contribute disease.Accordingly, we conducted...
The Chinese IBDV novel variant (nvIBDV), belonging to the genotype A2dB1b, an emerging pathotype that can cause subclinical disease with severe, prolonged immunosuppression, poses a new threat poultry industry. process of global origin, evolution and transmission dynamics nvIBDV, however, is poorly understood. In this study, phylogenetic trees, site substitutions amino acid (aa) highly accurate protein structure modelling, selection pressure, evolutionary nvIBDV were analysed. Interestingly,...
Abstract Differentiation between Crohn’s disease and intestinal tuberculosis is difficult but crucial for medical decisions. This study aims to develop an effective framework distinguish these two diseases through explainable machine learning (ML) model. After feature selection, a total of nine variables are extracted, including surgery, abdominal, bloody stool, PPD, knot, ESAT-6, CFP-10, dilatation comb sign. Besides, we compared the predictive performance ML methods with traditional...
Interferon regulatory factor 7 (IRF7)-mediated type I interferon antiviral response is crucial for regulating the host following viral infection in chickens. Infectious bursal disease virus (IBDV) a double-stranded RNA that induces immune suppression and high mortality rates chickens aged 3-6 weeks. Previous studies have shown IBDV antagonizes production to facilitate replication cell, IRF7 signaling might play an important role. However, underlying mechanisms enable block pathway remain...
We conducted an unbiased metagenomics survey using plasma from patients with chronic hepatitis B, C, autoimmune (AIH), non-alcoholic steatohepatitis (NASH), and without liver disease (control). RNA DNA libraries were sequenced filtrates enriched in viral particles to catalog virus populations. Hepatitis viruses readily detected at high coverage B but only a limited number of sequences resembling other found. The exception was library patient diagnosed C (HCV) infection that contained...
The purpose of the present study was to identify key long non-coding (lnc)RNAs in occurrence and development osteoporosis (OP) explore associated molecular mechanism. First, Gene Expression Omnibus (GEO) datasets, with words 'osteoporosis' 'HG-133A', were screened. RankProd R package used calculate dysregulated lncRNAs OP. Following this, bone marrow mesenchymal stem cells (BM-MSCs) harvested from 3-week-old Sprague Dawley rats employed for detection osteoblast differentiation....
Background: Although increasing data suggest that hyperthyroidism is associated with adverse pregnancy outcomes, there are only a few reports different conclusions on whether the mild transient reduction in thyrotropin (TSH) or without free thyroxine (FT4) elevation during early stage of also causes outcomes. Subjects and Methods: We analyzed from 3,783 women this study August 2011 to December 2013. Participants completed questionnaire survey. Samples blood were obtained 4th-8th week their...
Novel variant infectious bursal disease virus (nvIBDV) is an emerging pathotype that can cause sub-clinical with severe, prolonged immunosuppression in young chickens. At present, two major pathotypes, including vvIBDV and nvIBDV, are prevailing China. In this study, we propose the nvIBDV a new genotype (A2dB1b) also first isolated characterized reassortant strain YL160304 (A2dB3) segments A B derived, respectively, from HLJ-0504-like yellow chickens southern The causes more extensive...
As Th22 subsets are identified, their involvement in the pathogenesis of numerous autoimmune diseases has become apparent. In this study, we investigated differentiation cells thyroid including Hashimoto's thyroiditis (HT) and Graves' disease (GD). Besides, also explored an iodine-induced (AIT) model (i.e., NOD.H-2(h4) mice). HT patients, showed level circulating correlated with serum IL-22, was significantly higher than GD patients healthy control subjects. Levels IL-6, a major cell...
COVID-19 is caused by SARS-CoV-2 infection and was initially discovered in Wuhan. This outbreak quickly spread all over China then to more than 20 other countries. fluorescent microsphere immunochromatographic test strips were prepared the combination of time-resolved fluorescence immunoassay with a lateral flow assay. The analytical performance clinical evaluation this testing method done significance verified. LLOD antibody IgG IgM 0.121U/L 0.366U/L. specificity healthy people patients...
Infectious bursal disease virus (IBDV) infection causes highly contagious and immunosuppressive in poultry. The thymus, serving as the primary organ for T cell maturation differentiation, plays an important role pathogenicity of IBDV infected chickens. However, there are no reports on molecular pathogenesis thymus currently. aim study was to elucidate mechanisms underlying a field very virulent (vv) strain NN1172 SPF chickens using integrative transcriptomic proteomic analyses. Our results...
Sorafenib is a molecularly targeted drug used for treating hepatocellular carcinoma. However, sorafenib may affect the function of normal hepatocytes, and clinical application limited due to its adverse effects. The aim current study was improve effectiveness by preparing it as nanoparticle formulation using nanoprecipitation technology. combined with polyethylene glycol monomethyl ether‑racemic polylactic acid copolymer. properties nanoparticles, including particle size, ξ potential release...
Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative caused by virus (MDV). In recent years, the emergence of very virulent (vv) and/or plus (vv +) strains MDV in field has been suggested as one causes vaccination failure. The pathogenicity strain GX18NNM4, isolated from a clinical outbreak broiler breeder flock that was vaccinated with CVI988/Rispens, investigated. vaccination-challenge test, GX18NNM4 able to break through protections provided vaccines CVI988 and...
Marek's disease (MD) continues to threaten the sustainability of world poultry industry. In this study, sequences meq gene 220 MDV strains isolated during years 1964–2020 were analysed, including 50 from our group plus 170 isolates GenBank. Analyses, using phylogenetic trees, amino acid (aa)-mutation screening, evolutionary studies and transmission dynamics all performed. All divided into two clusters (Clusters 1 2), Cluster includes mild strains, vaccine foreign virulent while 2 was...
Infectious Bursal Disease Virus (IBDV) has haunted the poultry industry with severe, prolonged immunosuppression of chickens when infected at an early age and can easily lead to other secondary infections. Understanding pathogenic mechanisms could effective prevention control (IBD). Evidence suggests that N-terminal domain polymerase in segment B plays important role, but it is not clear which part or residual crucial for pathogenicity. Using a reverse genetics technique, molecular clone...
Infectious bursal disease virus (IBDV) is one of the most important infectious diseases poultry around world. Gut-associated lymphoid tissues (GALT) are first line defense host against infection. The purpose this study was to investigate role innate immune antiviral signaling triggered by Toll-like receptor 3 (TLR3), as well macrophage activation and cytokine response in intestinal lamina propria (ILP) cells after oral challenge IBDV relation virulence pathogenesis. results showed that...