A5001749711- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Renin-Angiotensin System Studies
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
Tianjin Medical University Cancer Institute and Hospital
2020-2023
Ministry of Education of the People's Republic of China
2020-2022
Rationale: Angiogenesis is a fundamental process of tumorigenesis, growth, invasion and metastatic spread.Extracellular vesicles, especially exosomes, released by primary tumors promote angiogenesis cancer progression.However, the mechanism underlying pro-angiogenic potency cell-derived exosomes remains poorly understood.Methods: Exosomes were isolated from breast cells with high potential (HM) low (LM).The effects these evaluated in vitro tube formation assays, wound healing rat arterial...
Abstract Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under glucose-deficient...
Abstract The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with multifunctional and multifaceted properties. By mediating protein-protein interactions, RACK1 integrates multiple intracellular signals involved in the regulation of various physiological pathological processes. Dysregulation has been implicated initiation progression many tumors. However, exact function cancer cellular processes, especially proliferation, remains controversial. Here, we show that...
Fructose is a very common sugar found in natural foods, while current studies demonstrate that high fructose intake significantly associated with increased risk of multiple cancers and more aggressive tumor behavior, but the relevant mechanisms are not fully understood.Tumor-grafting experiments vitro angiogenesis assays were conducted to detect effect conditioned medium fructose-cultured cells on biological function vascular endothelial (VECs) angiogenesis. 448 colorectal cancer specimens...
Angiotensin-converting enzyme 2 (ACE2) is a key of the renin-angiotensin system and well-known functional receptor for entry severe acute respiratory syndrome coronavirus (SARS-CoV-2) into host cells. The COVID-19 pandemic has brought ACE2 spotlight, expression in tumors its relationship with SARS-COV-2 infection prognosis cancer patients have received extensive attention. However, association between tumor therapy prognosis, especially breast cancer, remains ambiguous requires further...
Splicing factors (SFs) are proteins that control the alternative splicing (AS) of RNAs, which have been recognized as new cancer hallmarks. Their dysregulation has found to be involved in many biological processes cancer, such carcinogenesis, proliferation, metastasis and senescence. Dysregulation SFs demonstrated contribute progression prostate (PCa). However, a comprehensive analysis prognosis value PCa is limited. In this work, we systematically analysed 393 deeply characterize expression...
Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with carcinogenesis and progression breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, Basal-like BRCA, four- (
Recent evidence suggests that splicing factors (SFs) and alternative (AS) play important roles in cancer progression. We constructed four SF-risk-models using 12 survival-related SFs. In Luminal-A, Luminal-B, Her-2, Basal-Like BRCA, for three genes ( PAXBP1 , NKAP NCBP2 ), RBM15B PNN ACIN1 SRSF8 LSM3 SNRNP200 SNU13 SRPK3 PUF60 ) were constructed. These models have a promising prognosis-predicting power. The co-expression protein-protein interaction analysis suggest the SFs are highly...
<div>Abstract<p>Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under...
<p>Figure S6</p>
<p>Supplementary data</p>
<p>Figure S2</p>
<p>Figure S5</p>
<p>Figure S3</p>
<div>Abstract<p>Excessive fructose intake is associated with the occurrence, progression, and poor prognosis of various tumors. A better understanding mechanisms underlying functions in cancer could facilitate development treatment prevention strategies. In this study, we investigated functional association between utilization pancreatic ductal adenocarcinoma (PDAC) progression. Fructose be taken up metabolized by PDAC cells provided an adaptive survival mechanism for under...
<p>Figure S3</p>
<p>Figure S6</p>
<p>Figure s4</p>
<p>Supplementary data</p>
<p>Figure S1</p>
<p>Figure S5</p>
<p>Figure S1</p>
<p>Figure S2</p>
<p>Figure s4</p>