A5046290843- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- S100 Proteins and Annexins
- Drug Transport and Resistance Mechanisms
- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Hydrogels: synthesis, properties, applications
- Bioactive Compounds and Antitumor Agents
- Supramolecular Self-Assembly in Materials
- Proteoglycans and glycosaminoglycans research
- Protein Tyrosine Phosphatases
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- ATP Synthase and ATPases Research
- TGF-β signaling in diseases
- Photodynamic Therapy Research Studies
Tianjin Medical University Cancer Institute and Hospital
2012-2024
Xi'an Jiaotong University
2018-2023
Ministry of Education of the People's Republic of China
2012-2022
China XD Group (China)
2020
Tianjin Medical University
2012-2015
Gladstone Institutes
2005
University of California, San Francisco
2005
Microbial infection has been considered as one of the most critical challenges in bioengineering applications especially tissue regeneration, which engenders severe threat to public health. Herein, a hydrogel performing properties rapid self-healing, on-demand antibiosis and controlled cargo release was fabricated by simple assembly Fe complex cross-linker hyaluronic acid gel network. This is able locally degrade Fe3+ kill bacteria needed because hyaluronidase excreted surrounding bacteria,...
Multiresponsive adjuvant nanoparticles (RMmAGL) are fabricated to perform tumor-specific photothermal therapy while regulating the behavior of tumor-associated immune cells for primary tumor eradication and metastasis inhibition. Core-satellite-like RMmAGL have a core mannose-functionalized mesoporous silica loaded with TLR7 agonist imiquimod (R837@MSN-mannose) connected via hydrazone bonds satellites glutamine (Glu)- lysine (Lys)-comodified gold (AuNPs-Glu/Lys). During therapy, acidic...
Although immunotherapy has revolutionized oncotherapy, only ≈15% of head and neck squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An immunosuppressive tumor microenvironment (TME) dysregulation polycomb ring finger oncogene BMI1 are potential reasons for failure. Herein, to promote immunotherapeutic efficacy against HNSCC, an injectable nanocomposite hydrogel is developed with a polymer framework (PLGA-PEG-PLGA) that loaded both imiquimod encapsulated CaCO3...
Apolipoprotein (apo) E4, a 299-aa protein and major risk factor for Alzheimer's disease, can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro neurodegeneration behavioral deficits transgenic mice. To investigate this neurotoxicity, we expressed apoE4 with C- or N-terminal truncations mutations transfected Neuro-2a cells. ApoE4 (1-272) was neurotoxic, but full-length apoE4(1-299) apoE4(1-240) were not, suggesting the lipid-binding region (amino acids...
Transforming growth factor-beta (TGF-β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness advanced stages. The dual effect TGF-β on development is known paradox, remarkable functional conversion pivotal controversial phenomenon that has been widely investigated for decades. This may be attributed to cross talk between signaling other pathways, including EGF receptor (EGFR) during progression. However,...
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
Despite the resistance of triple-negative breast cancer (TNBC) to targeted hormone therapy, discovery azobenzene combretastatin A4 (Azo-CA4) provides therapeutic opportunities for TNBC. Here, Azo-CA4 was loaded in upconverting nanocarriers that could convert near-infrared (NIR) light UV activate Azo-CA4. Upon irradiation, Azo-CA4-loaded significantly reduced viability TNBC cells via both apoptosis and ferroptosis. The former induced by photoisomerization Azo-CA4, accompanied microtubule...
Inflammatory response plays a critical role in myocardial infarction (MI) repair. The neutrophil apoptosis and subsequent macrophage ingestion can result inflammation resolution initiate regeneration, while the therapeutic strategy that simulates enhances this natural process has not been established. Here, we constructed engineered apoptotic bodies (eNABs) to simulate apoptosis, which regulated enhanced MI eNABs were fabricated by combining body membrane excellent inflammation-tropism...
Rationale: Angiogenesis is a fundamental process of tumorigenesis, growth, invasion and metastatic spread.Extracellular vesicles, especially exosomes, released by primary tumors promote angiogenesis cancer progression.However, the mechanism underlying pro-angiogenic potency cell-derived exosomes remains poorly understood.Methods: Exosomes were isolated from breast cells with high potential (HM) low (LM).The effects these evaluated in vitro tube formation assays, wound healing rat arterial...
// Tong Wang 1,* , Jie Yuan Zhang 1 Ran Tian Wei Ji Yan Zhou Yi Yang Weijie Song Fei and Ruifang Niu Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center for Cancer, The Key Laboratory of Breast Prevention Therapy, Ministry Education, Tianjin, PR China * These authors have contributed equally to this work Correspondence to: Niu, email: Zhang, Keywords : Anxa2, breast cancer, epithelial–mesenchymal transition, epidermal growth factor receptor Received...
Abstract Tumor metastasis induced by drug resistance is a major challenge in successful cancer treatment. Nevertheless, the mechanisms underlying pro-invasive and metastatic ability of remain elusive. Exosome-mediated intercellular communications between cells stromal tumor microenvironment are required for initiation progression. Recent reports have shown that also promote aggression. However, little attention has been regarded on this aspect. Herein, we demonstrated drug-resistant...
The development of multidrug resistance greatly impedes effective cancer therapy. Recent advances in research have demonstrated that acquisition by cells is usually accompanied enhanced cell invasiveness. Several lines evidence indicated cross activation other signaling pathways during drug may increase invasive potential multidrug-resistant (MDR) cells. However, the accurate mechanism this process largely undefined. In study, to better understand associated molecular responsible for...
Acquirement of resistance is always associated with a highly aggressive phenotype tumor cells. Recent studies have revealed that Annexin A2 (Anxa2) key protein links drug and cancer metastasis. A high level Anxa2 in tissues correlated to phenotype. Increased expression appears be specific many drug-resistant The functional activity regulated by tyrosine phosphorylation at the Tyr23 site. Nevertheless, accurate molecular mechanisms underlying regulation whether necessary for enhanced invasive...
Abstract Implantation of biomedical devices accompanying infections has caused severe problems to public health that require feasible solutions. In this study, a simple approach is reported fabricate antimicrobial and antifouling dual‐functional coating. This coating consists substrate‐independent layer‐by‐layer (LBL) film formed by poly (diallyldimethylammonium) (PDDA) (styrenesulfonate) (PSS), where parts PSS PDDA are physically substituted hetero‐bifunctional polyethylene glycol (PEG)...
A tumor-selective drug delivery nanogel with redox-responsive size swelling and co-instantaneous release is developed. The formed by poly(ethylene glycol) diglycidyl ether cystamine double crosslinked hyaluronic acid (HA). disulfide bond in (Cys) charge of the responsiveness, while compact polymer network turns a capsule for effective loading. tumor targeting achieved known HA-receptor mediated endocytosis. responsive this releases happen cleavage following cell endocytosis, which triggered...
Accumulative evidence demonstrates that the protein tyrosine phosphatase Shp2 functions as a powerful tumor promoter in many types of cancers. Abnormal expression has been implicated human malignancies. Overexpression cancer tissues is correlated with metastasis, resistance to targeted therapy, and poor prognosis. The well-known function its positive role regulating cellular signaling initiated by growth factors cytokines, including interleukin-6 (IL-6). Several recent studies have shown...
Abstract The failure of chemotherapy and the emergence multidrug resistance (MDR) are major obstacles for effective therapy in locally advanced metastatic breast cancer. Overexpression drug transporter P-glycoprotein (P-gp) cancer cells is one main causes MDR due to its ability efflux anticancer drugs out cells. Although signaling node that regulates expression P-gp has been intensively investigated; regulatory mechanism underlying transport activity remains obscure. Herein, we reported...
Bacterial infection is one of serious problems hindering tissue regeneration, but strategies able to perform proper antibiosis with spatiotemporal controllability manipulate the local inflammation and immunity for effective healing infected wound still a challenge. Herein, we fabricated smart hydrogel ([email protected]) multiple responsiveness near infrared radiation, visible light, hyaluronidase hydrogen peroxide promoted via controllable anti-bacteria at designed locations time periods as...
Due to the unfavorable prognosis associated with lung adenocarcinoma (LUAD), development of targeted therapies and immunotherapies is essential. Cuproptosis, an emerging form regulated cell death, implicated in mitochondrial metabolism induced by copper ions. This study aimed explore prognostic value cuproptosis- immune-related genes (CIRGs) LUAD.
To investigate the role of tyrosine 23 (Tyr23) phosphorylation Annexin A2 (Anxa2) in regulating proliferation and invasion human breast cancer SK-BR-3 cells.A panel lentivirus plasmids expressing Anxa2-wide type (Ana2-WT), Anxa2-Y23A, Anxa2-Y23D was generated infected with cells. The monoclonal strains were screened. expression Anxa2-WT, determined by Western blot analysis. ability cells to proliferate detected through an MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]...
The emergence of multidrug resistance is always associated with more rapid tumor recurrence and metastasis. P-glycoprotein (P-gp), which a well-known multidrug-efflux transporter, confers enhanced invasion ability in drug-resistant cells. Previous studies have shown that P-gp probably exerts its tumor-promoting function via protein-protein interaction. These interactions were implicated the activation intracellular signal transduction. We previously showed binds to Anxa2 promotes...