A5101788215- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Advanced materials and composites
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Circular RNAs in diseases
- Airway Management and Intubation Techniques
- Plant biochemistry and biosynthesis
- Supramolecular Self-Assembly in Materials
- Ferrocene Chemistry and Applications
- Drug Solubulity and Delivery Systems
- Biofuel production and bioconversion
- Block Copolymer Self-Assembly
- Foreign Body Medical Cases
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Studies
- Cholinesterase and Neurodegenerative Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Plant Micronutrient Interactions and Effects
- Free Radicals and Antioxidants
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
Shanxi Medical University
2024
Second Hospital of Shanxi Medical University
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Tianjin University
2009-2023
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2020-2023
Wuhan University of Technology
2023
Chinese Academy of Sciences
2005-2022
Institute of Biophysics
2022
Tianjin Institute of Pharmaceutical Research (China)
2021
Ferroptotic antitumor therapy has been compromised by various intracellular antioxidants, particularly glutathione and thioredoxin. Both are cofactors of peroxide 4 (GPX4) that act against oxidative stress via catalyzing the reduction lipid peroxides. It was postulated tailored polymer micelles could enhance ferroptotic efficacy diminishing thioredoxin under hypoxia. The aim to engineer hypoxia-responsive for selective enhancement cell death in solid tumor. contains hydrophilic poly(ethylene...
Abstract The combination of apoptosis and ferroptosis is highly appealing in addressing the tumor heterogeneity‐induced therapy resistance. Reactive oxygen species (ROS)‐based cancer nanomedicine can assemble multiple cell death modalities a single platform, but potency induction limited. Here, novel mechano‐responsive polymeric micellar system for selective boosting ROS sensitization reported. mechanophore, ferrocene (Fc) key to such design, ultrasound speed up dissociation Fc release Fe 2+...
To overcome the surface instability of traditional polymeric membranes especially with superwetting behaviour, a robust superhydrophilic was fabricated nano-TiO<sub>2</sub> inlaid on hierarchical polylactide (PLA) ultrafiltration membrane <italic>via</italic> spin coating process.
Despite the resistance of triple-negative breast cancer (TNBC) to targeted hormone therapy, discovery azobenzene combretastatin A4 (Azo-CA4) provides therapeutic opportunities for TNBC. Here, Azo-CA4 was loaded in upconverting nanocarriers that could convert near-infrared (NIR) light UV activate Azo-CA4. Upon irradiation, Azo-CA4-loaded significantly reduced viability TNBC cells via both apoptosis and ferroptosis. The former induced by photoisomerization Azo-CA4, accompanied microtubule...
Abstract Ferroptosis is recently discovered programmed cell death, induced by cellular ferrous ion bursts and subsequent Fenton reactions. The iron source in tumor cells limited due to tightly controlled metabolism. Since hierarchical architecture rarely considered ferroptosis cancer treatment, multilayer Fe 2 O 3 architectures (UF@PPDF NPs) are developed modulating ultra‐small γ‐Fe nanocrystal assemblies, further conjugating targeting folic acid (FA), chemotherapeutic drug doxorubicin...
Abstract The dose‐dependent cardiomyopathy of adriamycin (doxorubicin) limits its long‐term clinical use, which is revealed as a consequence cardiomyocyte ferroptosis. As ferrous iron (Fe 2 + )‐dependent regulated cell death pathway, ferroptosis induced by the tailored lipid peroxides in membranes. Herein, iron‐chelating polymer micelles are reported for concurrent doxorubicin delivery and cardiotoxicity reduction. amphiphilic consists methoxy poly (ethylene glycol)‐ co ‐poly (glutamic acid)...
Abstract NaCl significantly enhanced the longer oligoarginine formation in oligomerization of L ‐arginine activated by N,N ′‐carbonyldiimidazole (CDI) homogeneous aqueous solution. The optimal concentration for highest yield is around 1 M . It suggested that weak interactions Cl − with positive‐charged guanidinium group oligoarginines formed are responsible enhancement NaCl. © 2005 Wiley Periodicals, Inc. Biopolymers 81: 1–7, 2006 This article was originally published online as an accepted...
Mahuang–Xingren (MX, Ephedra sinica Stapf- Prunus armeniaca L.) is a classic herb pair used in traditional Chinese medicine. This combined preparation reduces the toxicity of Xingren through stereoselective metabolism its main active ingredient amygdalin. However, whether stereoselectivity important pharmacokinetic properties amygdalin either decoction or dispensing granules unclear. Amygdalin hydrolyzed to metabolite, prunasin, which produces hydrogen cyanide by degradation cyano group. A...
Abstract Block copolymer nanolithography has attracted enormous interest in chip technologies, such as integrated silicon chips and biochips, due to its large-scale mass production of uniform patterns. We further modified this technology grow embossed nanodots, nanorods nanofingerprints polymer brushes on from their corresponding wet-etched nanostructures covered with pendent SiH x ( X = 1–3) species. Atomic force microscopy (AFM) was used image the topomorphologies multiple...
To investigate the correlation of serum levels bridging integrating factor 1 (BIN1) with acute myocardial infarction (AMI) and Killip class patients. We retrospectively collected data from 94 patients AMI 30 healthy individuals for analysis correlations BIN1 class, TIMI scores, neutrophil-to-lymphocyte ratio (NLR). also assessed diagnostic value combined NLR AMI. Serum were significantly lower in than (P=0.032). The I had (P=0.008). level was an independent predictor a predictive 0.630 (95%...
Abstract A series of difunctionalized 4‐hydroxybenzaldehyde derivatives (I) is designed, synthesized, and evaluated as cholinesterase (AChE, BChE) inhibitors.