A5101779092- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Cancer Genomics and Diagnostics
- Chemical synthesis and alkaloids
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Treatments and Mutations
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Tuberculosis Research and Epidemiology
- Marine Sponges and Natural Products
- Renal cell carcinoma treatment
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Studies
- Tumors and Oncological Cases
- Medical Research and Treatments
- Gallbladder and Bile Duct Disorders
- Brain Metastases and Treatment
- Bone Tumor Diagnosis and Treatments
- Anesthesia and Neurotoxicity Research
Huazhong University of Science and Technology
2019-2025
Affiliated Hospital of Qingdao University
2019-2025
Central Hospital of Wuhan
2025
Qingdao University
2019-2025
Inner Mongolia Maternal and Child Health
2025
Shandong University
2020-2023
Shandong Provincial Hospital
2023
Northeast Forestry University
2021-2022
Zhejiang University
2016-2022
Ningxia Medical University
2019-2022
Purpose: The study investigated the impact of TP53 mutations on clinical efficacy first-generation EGFR-tyrosine kinase inhibitors (TKIs) in Chinese patients with advanced or recurrent non-small-cell lung cancer (NSCLC). Patients and methods: Tissues from 163 NSCLC at Affiliated Hospital Qingdao University were analyzed by next-generation sequencing (NGS) to determine mutational status EGFR concurrent genetic alterations. evaluated relation baseline patient characteristics treatment outcomes...
Bipoladiens A–E (1–5), five new ophiobolin-derived sesterterpenoids, and a known compound 6 (bipolaricin R) were isolated from the cultures of phytopathogenic fungus Bipolaris maydis. Their structures absolute configurations elucidated based on comprehensive spectroscopic analyses, HRESIMS, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction analyses. Notably, 1 has an undescribed tetracyclic 5/8/5/7 fused carbon skeleton, 2 possesses rare multicyclic caged...
Abstract Background Recent studies have shown that according to the expression levels of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor (NEUROD1), and POU class 2 homeobox 3 (POU2F3), small cell lung cancer (SCLC) can be divided into four subtypes: SCLC-A (ASCL1-dominant), SCLC-N (NEUROD1-dominant), SCLC-P (POU2F3-dominant), SCLC-I (triple negative or SCLC-inflamed). However, there are limited data on clinical characteristics prognosis molecular subtypes SCLC. Methods...
Lung cancer is the most common cause of cancer-related death among all human cancers and five-year survival rates are only 23%. The precise molecular mechanisms non-small cell lung (NSCLC) still unknown. aim this study was to identify validate key genes with prognostic value in tumorigenesis.Four GEO datasets were obtained from Gene Expression Omnibus (GEO) database. Common differentially expressed (DEGs) selected for Kyoto Encyclopedia Genes Genomes pathway analysis Ontology enrichment...
Twelve previously undescribed ophiobolin-type sesterterpenoids, undobolins A-L (
Benign biliary stricture of anastomotic stoma is frequent after reconstruction. To prevent such a complication, new paclitaxel-coated poly-L-lactide acid (PLLA) biodegradable biopolymer stent was designed. This original device intended both to exert adequate mechanical support properties and allow controlled drug delivery from the coating, with goal favoring wound healing reconstruction.PLLA stents coated three different paclitaxel concentrations were implanted in anastomosis mongrel dogs...
A fluidized bed bioreactor containing encapsulated hepatocytes may be a valuable alternative to hollow fiber for achieving the improved mass transfer and scale-up potential necessary clinical use. However, conventional (FBB) operating under high perfusion velocity is incapable of providing desired performance due resulting damage cell-containing microcapsules large void volume. In this study, we developed novel diversion-type microcapsule-suspension (DMFBB). The volume in stability...
Abstract Objectives The chemokine CXCL1, known as growth-related oncogene α (GRO-α), is a potent chemoattractant and regulator of neutrophils. purpose our study was to evaluate the regulatory response CXCL1 in serum patients with systemic lupus erythematosus (SLE) active stage disease assess whether it implicated pathogenesis/inflammatory process lupus. Methods concentrations were examined 90 SLE patients, 56 other autoimmune diseases (OADs) 100 healthy controls using enzyme-linked...
Lasiodiplodiapyrones A and B (1 2), two new preussomerin derivatives, possessing an unexpected 6-methyl-4H-furo[3,2-c]pyran-4-one moiety a highly functionalized conjoint complicated polycyclic ring system, along with known congeners (3 4), were isolated from the fungus Lasiodiplodia pseudotheobromae. Their structures including absolute configurations determined by spectroscopic analyses, Mosher's method, ECD calculations. biosynthetic pathway was proposed to explain origin of...
Whether an additional Braun enteroenterostomy is necessary in reducing delayed gastric emptying (DGE) after pancreaticoduodenectomy (PD) has not yet been well investigated. Herein, this retrospective study, 395 consecutive cases of patients undergoing classic PD from 2009 to 2013 were reviewed. Patients with and without compared preoperative baseline characteristics, surgical procedure, postoperative diagnosis, morbidity including DGE. The DGE was defined classified by the International...
Talaronoids A–D (<bold>1–4</bold>), four fusicoccane diterpenoids with an unexpected tricyclic 5/8/6 carbon skeleton from <italic>Talaromyces stipitatus</italic>, represent the first examples of natural products a benzo[<italic>a</italic>]cyclopenta[<italic>d</italic>]cyclooctane skeleton.
Based on the pathogenesis of severe acute pancreatitis and our experimental studies, to investigate effect dexamethasone dextran in treatment patients with pancreatitis.Thirty-two were treated 0.5-1 mg/kg per day for 3-5 d, 500-1,000 mL/d 40 7 besides routine therapy.After 4-8 h treatment, abdominal pain began be relieved; range tenderness localized 27 patients. They cured nonsurgical treatment. Five them deteriorated, surgery. Four this group died.Dexamethasone block pathologic process...