A5077277741- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Advanced Glycation End Products research
- Phagocytosis and Immune Regulation
- RNA Research and Splicing
- Shoulder and Clavicle Injuries
- Immune cells in cancer
- Shoulder Injury and Treatment
- Cancer Mechanisms and Therapy
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Cellular transport and secretion
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Eicosanoids and Hypertension Pharmacology
- Cannabis and Cannabinoid Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
Academy of Military Medical Sciences
2025
RWTH Aachen University
2021-2024
Third Affiliated Hospital of Southern Medical University
2024
Universitätsklinikum Aachen
2021
Qingdao University
2019-2020
Affiliated Hospital of Qingdao University
2019-2020
People’s Hospital of Rizhao
2017
Purpose: The study investigated the impact of TP53 mutations on clinical efficacy first-generation EGFR-tyrosine kinase inhibitors (TKIs) in Chinese patients with advanced or recurrent non-small-cell lung cancer (NSCLC). Patients and methods: Tissues from 163 NSCLC at Affiliated Hospital Qingdao University were analyzed by next-generation sequencing (NGS) to determine mutational status EGFR concurrent genetic alterations. evaluated relation baseline patient characteristics treatment outcomes...
Treatment resistance of the tumors to photodynamic therapy (PDT) owing O2 deficiency largely compromised therapeutic efficacy, which could be addressed via modulating oxygen levels by using self-enriched nanosystems. Here, we report on augmenting O2-evolving strategy based a biomimetic, catalytic nanovehicle (named as N/P@MCC), constructed catalase-immobilized hollow mesoporous nanospheres enveloping cancer cell membrane (CCM), acts an efficient nanocontainer accommodate nitrogen-doped...
Palytoxin (PTX), a toxin naturally synthesized by marine organisms like Palythoa, Ostreopsis and Trichodesmium spp. in tropical temperate seas, bioaccumulates fish crustaceans, thereby exposing humans through the food chain. Although growing evidence highlights PTX's lethal hepatotoxicity, nephrotoxicity, cardiotoxicity, its neurotoxic effects underlying mechanisms remain elusive. In this study, we assessed cerebral neurotoxicity of PTX using HT22 neuronal cells chronic mouse model,...
Alternative splicing (AS) is fundamental to transcriptome and proteome richness, data from recent studies suggested a critical association between AS oncogenic processes.To date, no systematic analysis has been conducted on the perspective of different sexes subtypes in non-small-cell lung cancer (NSCLC).Thus, we integrated information NSCLC patients The Cancer Genome Atlas (TCGA) evaluated profiles perspectives sex subtype.Eventually, total 813 1020 events were found be significantly...
Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related 2 (Nrf2) pathway agonist, on sterile inflammation and ischemia-reperfusion injuries to liver after hemorrhagic shock (HS) followed by resuscitation (R). Male C57/BL6 wild-type transgenic ARE- luc mice were exposed mean arterial pressure-controlled HS. Fluid was performed 90 min HS, SFN administrated intraperitoneally that. The animals sacrificed at 6 h, 24 72 h...
Lung cancer is the most common cause of cancer-related death among all human cancers and five-year survival rates are only 23%. The precise molecular mechanisms non-small cell lung (NSCLC) still unknown. aim this study was to identify validate key genes with prognostic value in tumorigenesis.Four GEO datasets were obtained from Gene Expression Omnibus (GEO) database. Common differentially expressed (DEGs) selected for Kyoto Encyclopedia Genes Genomes pathway analysis Ontology enrichment...
Objective: Existing research suggests that bone marrow-derived mesenchymal stem cells (BMSCs) may promote endogenous repair. This be through the secretion of factors stimulate repair processes or directly differentiation into osteoblast-progenitor cells. However, osteogenic potential BMSCs varies among different tissue sources (e.g., mandibular versus long BMSCs). The main aim this study was to investigate difference in capacity between (mBMSCs) and tibial (tBMSCs). Materials Methods:...
Abstract Extracellular vesicles (EVs) mediate cell-to-cell communication by horizontally transferring biological materials from host cells to target cells. During exposure pathogens, pathogen-associated molecular patterns (e.g., lipopolysaccharide, LPS) get in contact with endothelial and stimulate the secretion of cell-derived EVs (E-EVs). The triggered is known have a modulating influence on EVs-receiving Macrophages, major component innate immunity, are polarized upon receiving external...
Purpose Facial skin fibroblasts imposed with cyclic stretch at 10% magnitude display considerable mechanotransduction properties and biochemical reactions in our previous study. However, it is poorly understood how these shared traits are fully parallel to the common features across all derived from different skin-based anatomical regions response stimulation. Thus, purpose of this study was evaluate effects various stretches on multiple sites human bodies, optimal defined based changes cell...
Abstract Background The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who received EGFR-tyrosine inhibitors (TKIs) ALK-TKIs based targeted therapy remains controversial. Therefore, the present meta-analysis was performed to investigate association between and prognosis NSCLC undergoing EGFR-TKIs treatments. Methods Eligible studies were...
Abstract Background The reduction and fixation of Medial humeral calcar is difficult in the treatment elderly proximal humerus Neer 3 4-part fractures with a single lateral locking plate. Our study investigated efficacy an intramedullary supporting plate combined for 3- through deltoid splitting approach. Methods From June 2022 to December 2022, we treated six patients using support combination Follow-up time was 6–12 months. Assessment indicators included fracture union, quality reduction,...
<title>Abstract</title> Hemorrhagic shock/resuscitation (HS/R) can lead to acute kidney injury, mainly manifested as oxidative stress and inflammatory injury in the renal tubular epithelial cells, well abnormal autophagy apoptosis. Sulforaphane (SFN), an agonist of nuclear factor-erythroid factor 2-related 2 (Nrf2) signaling pathway, is involved multiple biological activities, such anti-inflammatory, antioxidant, autophagy, apoptosis regulation. This study investigated effect SFN on after...
Alternative splicing (AS) is fundamental to the diversity of transcriptome and proteome, data from recently studies suggested a critical association between alternative oncogenic processes. To date there has been no systematic analysis on signature in different gender subtype non-small cell lung cancer. Thus, we integrated information NSCLC patients The Cancer Genome Atlas (TCGA) evaluated profiles perspectives. Eventually, total 3357 1983 AS events were found significant related overall...
Abstract Background The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who received EGFR-tyrosine inhibitors (TKIs) ALK-TKIs based targeted therapy remains controversial. Therefore, the present meta-analysis was performed to investigate association between and prognosis NSCLC undergoing EGFR-TKIs treatments. Methods Eligible studies were...
Abstract Background The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who received EGFR-tyrosine inhibitors (TKIs) ALK-TKIs based targeted therapy remains controversial. Therefore, the present meta-analysis was performed to investigate association between and prognosis NSCLC undergoing EGFR-TKIs treatments. Methods Eligible studies were...