A5101873062- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Cancer-related gene regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Nicotinic Acetylcholine Receptors Study
- Crystallography and molecular interactions
- Covalent Organic Framework Applications
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Receptor Mechanisms and Signaling
- Atmospheric chemistry and aerosols
- Metal complexes synthesis and properties
- Ion channel regulation and function
- Lanthanide and Transition Metal Complexes
- Plant biochemistry and biosynthesis
- MicroRNA in disease regulation
- Immune cells in cancer
- Vehicle emissions and performance
- Inflammasome and immune disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Nitrogen and Sulfur Effects on Brassica
- RNA regulation and disease
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023-2024
Sun Yat-sen University
2023-2024
China Agricultural University
2024
Anqing Normal University
2013-2023
Shandong First Medical University
2021-2023
Huazhong University of Science and Technology
2023
Union Hospital
2023
Union Hospital
2023
Anhui Medical University
2021-2022
Nanoplastics (NPs) are a newly discovered type of environmental pollutant. The potential for neurotoxicity caused by NPs and their mechanisms unclear. present study aimed to determine the molecular mechanism underlying induced NPs. Microglia (BV2) cells were used in vitro studies, it was found that invaded cells, activated inflammasomes, release significant quantities inflammatory factors detection response‑associated proteins through Western blot ELISA. By FITC, SOD, GSH, cellular iron...
Design of oligonucleotide probe-based isothermal amplification with the ability to identify miRNA biomarkers is crucial for molecular diagnostics. In this work, we engineered a miRNA-21-responsive G-quadruplex-embedded self-quenching probe (GE-SQP) that can regulate single multiplex amplifications. The free GE-SQP tightly locked in quenching state no active G-quadruplexes. Introduction target hybridize would induce significantly build lot one-bulb-contained road lamp (OC-RLP) and...
Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled from channel gating, underlying mechanism remains to be defined. Here, we examine behind lipid-dependent uncoupling by comparing propensities of two prokaryotic homologs, Gloebacter Erwinia ligand-gated ion (GLIC ELIC, respectively), adopt similar conformation. Membrane-reconstituted...
Silica nanoparticles (SiNPs) have been widely used in food, cosmetics, medicine and other fields; however, there growing concerns regarding their potential adverse effects on health. A large number of studies confirmed that SiNPs with small particle diameters can pass through the blood brain barrier, causing irreversible damage to nervous system. This study aims further explore molecular mechanism neurotoxicity provide a toxicological basis for medical application SiNPs.We conducted an vitro...
Two novel Pb(II)-based metal–organic frameworks (MOFs) based on the rigid bitetrazolate ligand 1,4-benzeneditetrazol-5-yl (H2BDT) have been synthesized under hydrothermal conditions and fully characterized. In these two compounds, [Pb4(OH)4(BDT)2]·2H2O (1) [Pb4(OH)4(BDT)]·BDT·2H2O (2), H2BDT ligands exhibit three different coordination modes which are firstly reported in M-BDT frameworks, constructing disparate architectures by bridging same cubane-shaped [Pb4(OH)4]4+ building units....
Using 4-substituted tetrazole–benzoate ligands, 4-aminophenyl-1H-tetrazole (HL1) and 4-carboxyphenyl-1H-tetrazole (H2L2), five metal–organic coordination polymers formulated as [Co3(OH)2(L1)4(H2O)2]2n (1), [Zn(L1)2]n (2), [Ag(L1)]n (3), [Co(L2)(H2O)]n (4) [Pb(L2)]n (5) have been hydro(solvo)thermally synthesized structurally characterized by single-crystal X-ray diffraction. Due to the effects of different metal centers substituted groups such –NH2 –COOH, compounds 1–5 demonstrate...
GdNbO<sub>4</sub>:Ln<sup>3+</sup>(Ln = Dy, Eu) single crystal phosphors are very important for potential applications in optoelectronics and solid-state lighting general illumination.
Abstract BACKGROUND In this study, a low‐cost and environment‐friendly alginate–chitosan hybrid adsorbent (depicted as Alg‐Chi) was developed for the removal of Pb 2+ from water. RESULTS Experimental results showed that Alg‐Chi exhibits high selectivity affinity . The coefficients /Cr 3+ , /Co /Cd /Zn /Cu are all >5. It can uptake 96.8% ‐containing solutions (1.5 mmol L −1 ), maximum adsorption capacity reaches 468.5 mg g which is higher than most reported adsorbents Moreover, also be...
Three new Sc-MOFs have been synthesized using H<sub>2</sub>pydc linker and Sc(<sc>iii</sc>) ions. <bold>1</bold> features a ladder-shaped chain, <bold>2</bold> displays waved layer <bold>3</bold> exhibits (3,3)-connected <bold>nbo-a</bold> network. All three compounds exhibit good catalytic abilities for the cyanosilylation of aldehyde.
By reaction of 3,3′,5,5′-biphenyltetracarboxylic acid (H4BPTC) with various lanthanide ions, seven novel three dimensional (3D) metal–organic frameworks (MOFs) have been prepared under solvothermal conditions, namely, [Ln3(BPTC)3(H2O)2]·3H3O·4H2O·3DMF (DMF = N,N-dimethylformamide, Ln Eu (1), Tb (2), Sm (3) Dy (4)), [Nd(BPTC)(H2O)2]·H3O·DMF (5), [Er2(BPTC)(HCOO)3(H2O)2]·(CH3)2NH2 (6), and [Tm12(BPTC)8(HCOO)11(H2O)10]·10DMF·7(CH3)2NH2 (7). Combining different ions diversity coordination modes...
Silica nanoparticles (SiNPs) have been widely used in electronics, chemistry, and biomedicine. Human exposure to SiNPs possible health effects attracted much attention. The potential cardiovascular toxicity of their related mechanisms are still unclear. Therefore, this study, we investigated the toxic on human umbilical vein endothelial cells (HUVECs). We found that could induce HUVECs ferroptosis. results showed level intracellular divalent iron lipid peroxidation increased, mitochondrial...
The mechanism of the sterile inflammatory response in respiratory tract induced by exposure to particles has not been fully elucidated. aim our study is explore earlier events initiating at molecular and cellular level primary cultured human airway epithelial cells (AEC) exposed silica order provide information for diagnosis prevention particle-induced toxicity as well possible on genesis silicosis. We isolated AEC from three healthy adults treated them with different concentrations 48 h....
Mahuang–Xingren (MX, Ephedra sinica Stapf- Prunus armeniaca L.) is a classic herb pair used in traditional Chinese medicine. This combined preparation reduces the toxicity of Xingren through stereoselective metabolism its main active ingredient amygdalin. However, whether stereoselectivity important pharmacokinetic properties amygdalin either decoction or dispensing granules unclear. Amygdalin hydrolyzed to metabolite, prunasin, which produces hydrogen cyanide by degradation cyano group. A...