A5100443951- Extracellular vesicles in disease
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Heat shock proteins research
- Biomedical Research and Pathophysiology
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Trace Elements in Health
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Axon Guidance and Neuronal Signaling
- Silk-based biomaterials and applications
- melanin and skin pigmentation
- Mitochondrial Function and Pathology
- Dermatologic Treatments and Research
- Genetics, Aging, and Longevity in Model Organisms
- Inflammasome and immune disorders
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Diabetic Foot Ulcer Assessment and Management
Zunyi Medical University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Sun Yat-sen University
2020-2023
Tianjin Medical University Cancer Institute and Hospital
2021
Boston Medical Center
2006-2021
Boston University
2006-2021
Hubei University of Medicine
2017
Guangdong Medical College
2014-2015
Moderate inflammation is essential for standard wound healing. In pathological conditions, such as diabetes, protracted and refractory wounds are associated with excessive inflammation, manifested by persistent proinflammatory macrophage states. However, the mechanisms still unclear. Herein, we perform a metabolomic profile find significant phenylpyruvate accumulation in diabetic foot ulcers. Increased impairs healing augments inflammatory responses, whereas reducing via dietary...
Although hsp70 antagonizes apoptosis-inducing factor (AIF)-mediated cell death, the relative importance of preventing its release from mitochondria versus sequestering leaked AIF in cytosol remains controversial. To dissect these two protective mechanisms, deletion mutants lacking either chaperone function (hsp70-deltaEEVD) or ATPase (hsp70-deltaATPase) were selectively overexpressed before exposing cells to a metabolic inhibitor, an insult sufficient cause mitochondrial release, nuclear...
Abstract Tumor metastasis induced by drug resistance is a major challenge in successful cancer treatment. Nevertheless, the mechanisms underlying pro-invasive and metastatic ability of remain elusive. Exosome-mediated intercellular communications between cells stromal tumor microenvironment are required for initiation progression. Recent reports have shown that also promote aggression. However, little attention has been regarded on this aspect. Herein, we demonstrated drug-resistant...
The dysfunction of endothelial cells caused by hyperglycemia is observed as a decrease in neovascularization diabetic wound healing. Studies have found that epidermal stem (EpiSCs) can promote the angiogenesis full-thickness wounds. To further explain therapeutic effect EpiSCs, EpiSC–derived exosomes (EpiSC-EXOs) are considered main substance contributing to cell effectivity. In our study, EpiSCs and EpiSC-EXOs were supplied dorsal wounds db/db mice. Results showed could colonize area both...
Abstract Background The composite transplantation of a split-thickness skin graft (STSG) combined with an acellular dermal matrix (ADM) is promising repair method for full-thickness defects. Due to delayed vascularization the ADM, no currently available engineered tissue able permanently cover defects via single-stage procedure. Epidermal stem cells (EpSCs) have been found promote angiogenesis in wound bed. Whether EpSCs can induce early substitutes and survival tissue-engineered needs be...
The aim of the present study was to determine antitumor effects hyperthermic CO2 (HT-CO2)-treated dendritic cell (DC)-derived exosomes (Dex) on human gastric cancer AGS cells. Mouse-derived DCs were incubated in HT-CO2 at 43°C for 4 h. culture supernatant then isolated. Cell proliferation analyzed using counting kit-8 (CCK-8) assay. apoptosis observed flow cytometry, Hoechst 33258 staining and analysis caspase-3 activity. In addition, tumor cells evaluated xenotransplant nude mice. markedly...
In order to evaluate the anticancer effect of 10-hydroxycamptothecin (HCPT) in terms inducing apoptosis human osteosarcoma cells, its apoptosis‑inducing molecular mechanisms were investigated. present study, effects HCPT revealed result suppressed cell viability, increased cytotoxicity, induction and an augmented apoptotic nucleolus cells. MG‑63 cells cultured with (0, 20, 40 80 nM) for 24 48 h. An MTT assay a lactate dehydrogenase used analyze on viability cytotoxicity apoptosis, caspase‑9...
Abstract Keloid is a benign fibro‐proliferative dermal tumour formed by an abnormal scarring response to injury and characterised excessive collagen accumulation invasive growth. The pathophysiology of keloids complex, the treatment for still unmet medical need. Here, we investigated transcriptional gene that influences keloid development comparing keloid, non‐lesioned skin normal as well fibroblast (GSE83286, GSE92566, GSE44270). Based on analysis, 146 up‐regulated genes 48 down‐regulated...
Objective To observe the effects of heat-CO2-treated dendritic cells (DC)-derived dexosomes (DEXs) on apoptosis human gastric adenocarcinoma cell line AGS and investigate applied value heat-CO2 pneumoperitoneum during laparoscopic surgery.Methods An in vitro experimental box was built.After treatment,the DC-derived DEXs were isolated identified through TEM Western blotting.AGS co-cultured with DEXs,apoptosis examined by Annexin V/propidium iodide (PI) flow cytometry Hoechst 33258 fluorescent...