A5101931106- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Diabetic Foot Ulcer Assessment and Management
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Pressure Ulcer Prevention and Management
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Silk-based biomaterials and applications
- Kruppel-like factors research
- Electrospun Nanofibers in Biomedical Applications
- Fibroblast Growth Factor Research
- Laser Applications in Dentistry and Medicine
- Periodontal Regeneration and Treatments
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Hippo pathway signaling and YAP/TAZ
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Connective Tissue Growth Factor Research
- melanin and skin pigmentation
- Histone Deacetylase Inhibitors Research
The First Affiliated Hospital, Sun Yat-sen University
2011-2025
Sun Yat-sen University
2014-2025
Wenzhou Medical University
2021-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Ministry of Agriculture and Rural Affairs
2021
Institute of Vegetables and Flowers
2021
Chinese Academy of Agricultural Sciences
2021
National Natural Science Foundation of China
2016
Third Affiliated Hospital of Sun Yat-sen University
2014
Zero to Three
2014
Moderate inflammation is essential for standard wound healing. In pathological conditions, such as diabetes, protracted and refractory wounds are associated with excessive inflammation, manifested by persistent proinflammatory macrophage states. However, the mechanisms still unclear. Herein, we perform a metabolomic profile find significant phenylpyruvate accumulation in diabetic foot ulcers. Increased impairs healing augments inflammatory responses, whereas reducing via dietary...
The continuous imbalance of the diabetic wound microenvironment is an important cause chronic nonhealing, which manifests as a vicious cycle between excessive accumulation reactive oxygen species (ROS) and abnormal healing. Regulating by suppressing inflammation, oxidative stress, bacterial infection key challenge in treating wounds. In this study, ROS-responsive hydrogels are developed composed silk fibroin methacrylated (SFMA), modified collagen type III (rCol
Abstract Background Treatment of chronic wounds using traditional surgical procedures is challenging because the low graft take rates. This study investigated combination approach split-thickness autografts with harvested skin cell suspension for wound treatment. Methods randomized clinical trial enrolled patients between March 2012 and December 2013. Patients who were assigned randomly to active treatment received a autograft combined suspension. Control alone. The primary outcome was rate...
Abstract Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by regulating nuclear factor-E2-related factor (Nrf2), which mediates the expression anti-inflammatory- pro-survival-related genes vascular endothelium, thereby improving function. Methods Nrf2 knockout (Nrf2 KO) C57BL/6 background...
Acute myocardial infarction (MI) triggers oxidative stress, which worsen cardiac function, eventually leads to remodeling and heart failure. Unfortunately, effective therapeutic approaches are lacking. Fibroblast growth factor 7 (FGF7) is proved with respect its proliferative effects high expression level during embryonic development. However, the regulatory role of FGF7 in cardiovascular disease, especially MI, remains unclear. was significantly decreased a mouse model at days after MI....
Abstract As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma one leading causes cancer death worldwide. Its prognostic relevance and biological functions glioma remain obscure. We focused on role, mechanism, value cells. Herein, was identified as novel potential oncogene tissues from GEO TCGA datasets. highly expressed tissues, predicting poor prognosis patients. Knockdown inhibited proliferation invasion vitro, whereas upregulation presented opposite...
The dysfunction of endothelial cells caused by hyperglycemia is observed as a decrease in neovascularization diabetic wound healing. Studies have found that epidermal stem (EpiSCs) can promote the angiogenesis full-thickness wounds. To further explain therapeutic effect EpiSCs, EpiSC–derived exosomes (EpiSC-EXOs) are considered main substance contributing to cell effectivity. In our study, EpiSCs and EpiSC-EXOs were supplied dorsal wounds db/db mice. Results showed could colonize area both...
Skin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role skin diseases developments. We conducted Mendelian randomization study determine causal association between fibrosis.
Diabetic foot ulcer is a common and serious complication of diabetes, with high risk amputation, recurrence, mortality. Aiming at the characteristics diabetic wounds based on result network pharmacology, tailored ligand cyanidin-3-O-glucoside (C3G) was selected to construct metal-phenolic (CM) through self-assembly reaction manganese ions. CM integrates pharmacological advantages C3G in antidiabetes anti-inflammatory activity networks by simulating metal coordination structure antioxidant...
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target...
Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role...
BackgroundKeloid and hypertrophic scar (HS) are two pathological forms of excessive dermal fibrosis, which due to aberrant wound‐healing responses. Accumulating evidence suggests that activity growth factors increased numbers factor receptors play an important role in the formation scar.
Purpose: Previous study reported that Piezo1 was highly expressed in glioma and promoted the proliferation of cells, suggesting overexpression might contribute to poor prognosis patients. Thus, this aimed identify whether may become a new prognostic biomarker for Patients Methods: Firstly, expression gliomas analyzed through GEO Oncomine dataset, verified by qRT-PCR immunohistochemistry (IHC) methods. A total 183 patients were included between January 2010 December 2014. Kaplan-Meier...
Abstract Background Split-thickness skin graft (STSG) is used frequently, but may result in complications at the donor site. Rapid healing of donor-site wounds critical to relieving morbidity. This study investigated whether autologous cell suspension could improve STSG wounds. Methods Between September 2014 and February 2016, patients requiring STSGs were randomized receive plus hydrocolloid dressings (experimental group) or alone (control for The primary outcome was time complete...
Abstract Background Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confined utilization and function cells (EBCs), especially stem (ESCs) in it. This study investigated whether precoating fibronectin (FN) on wound bed before spraying EBCs could overcome these further explored its possible mechanisms. Methods In vitro study, were isolated...
Immunotherapy is an effective therapeutic approach for multiple human cancer types. However, the correlations between EVA1C and patients' prognosis as well immune infiltration remain obscure. Herein, we employed transcriptomic clinical data extracted from two independent databases to systematically investigate role of in oncological context.The differential expression was analyzed via TCGA Oncomine databases. We evaluated influence on using Kaplan-Meier plotter. then used profiler calculate...