A5067899250- RNA modifications and cancer
- HVDC Systems and Fault Protection
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Insect symbiosis and bacterial influences
- Dermatologic Treatments and Research
- Chronic Kidney Disease and Diabetes
- DNA and Biological Computing
- Advanced Data Storage Technologies
- RNA and protein synthesis mechanisms
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- 3D Printing in Biomedical Research
Sun Yat-sen University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
BGI Group (China)
2019
BackgroundKeloid and hypertrophic scar (HS) are two pathological forms of excessive dermal fibrosis, which due to aberrant wound‐healing responses. Accumulating evidence suggests that activity growth factors increased numbers factor receptors play an important role in the formation scar.
Abstract N 6 -deoxyadenosine methylation (6mA) is the most widespread type of DNA modification in prokaryotes and also abundantly distributed some unicellular eukaryotes. However, 6mA levels are remarkably low mammals. The lack a precise comprehensive mapping method has hindered more advanced investigations 6mA. Here, we report new MM-seq (modification-induced mismatch sequencing) for genome-wide based on novel detection principle. We found that modified bases prone to form local open region...
Abstract N6-methyladenine (m6A) stands out as the most prevalent internal chemical modification on mammalian mRNA, playing a vital role in diverse biological processes. Despite considerable advancements individual cell line studies, characteristics of m6A sites across distinct lines or tissues remain elusive. In this study, we have successfully identified approximately 1.5 million high-confidence human and mouse using published m6A-seq data. By categorizing into different consistency levels,...
IntroductionTubular epithelial cells under adaptive state (aTEC) have been frequently reported in the injured kidney closely associated with disease progression. However, whether aTEC is present urine of Diabetic Kidney Disease (DKD) patients and its clinical implication not assessed.MethodsUrine samples from early advanced DKD were collected subjected to single cell RNA sequencing (scRNA-seq). nucleus RNA-seq, spatial scRNA-seq bulk RNA-seq datasets employed reconstruct their local...