A5028611090- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Pressure Ulcer Prevention and Management
- Silk-based biomaterials and applications
- Connective Tissue Growth Factor Research
- Nuclear Physics and Applications
- Laser Applications in Dentistry and Medicine
- IL-33, ST2, and ILC Pathways
- Periodontal Regeneration and Treatments
- Dermatology and Skin Diseases
- Radiation Detection and Scintillator Technologies
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Melanoma and MAPK Pathways
- Skin Protection and Aging
- Nanoplatforms for cancer theranostics
- Diagnosis and Treatment of Venous Diseases
- Respiratory Support and Mechanisms
- Atomic and Subatomic Physics Research
- Cancer Genomics and Diagnostics
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Sun Yat-sen University
2014-2025
Ludong University
2024
Central South University
2024
Xiangya Hospital Central South University
2024
Dongfeng General Hospital
2022
China National Pharmaceutical Group Corporation (China)
2022
Hubei University of Medicine
2022
First Hospital of China Medical University
2021
China Medical University
2021
Moderate inflammation is essential for standard wound healing. In pathological conditions, such as diabetes, protracted and refractory wounds are associated with excessive inflammation, manifested by persistent proinflammatory macrophage states. However, the mechanisms still unclear. Herein, we perform a metabolomic profile find significant phenylpyruvate accumulation in diabetic foot ulcers. Increased impairs healing augments inflammatory responses, whereas reducing via dietary...
Dectin-1 functions as a pattern recognition receptor for sensing fungal infection. It has been well-established that induces innate immune responses through caspase recruitment domain-containing protein 9 (CARD9)-mediated NF-κB activation. In this study, we find CARD9 is dispensable activation induced by ligands, such curdlan or Candida albicans yeast. contrast, regulates H-Ras linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated kinase (ERK) and...
The continuous imbalance of the diabetic wound microenvironment is an important cause chronic nonhealing, which manifests as a vicious cycle between excessive accumulation reactive oxygen species (ROS) and abnormal healing. Regulating by suppressing inflammation, oxidative stress, bacterial infection key challenge in treating wounds. In this study, ROS-responsive hydrogels are developed composed silk fibroin methacrylated (SFMA), modified collagen type III (rCol
Abstract Background Treatment of chronic wounds using traditional surgical procedures is challenging because the low graft take rates. This study investigated combination approach split-thickness autografts with harvested skin cell suspension for wound treatment. Methods randomized clinical trial enrolled patients between March 2012 and December 2013. Patients who were assigned randomly to active treatment received a autograft combined suspension. Control alone. The primary outcome was rate...
Activation of various C-type lectin receptors (CLRs) initiates potent proinflammatory responses against microbial infections. However, how activated CLRs are negatively regulated remains unknown. In this study, we report that activation Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination degradation in a Syk-dependent manner. Furthermore, found E3 ubiquitin ligase Casitas B-lineage lymphoma protein b (Cbl-b) mediates the these through associating with each other via...
The dysfunction of endothelial cells caused by hyperglycemia is observed as a decrease in neovascularization diabetic wound healing. Studies have found that epidermal stem (EpiSCs) can promote the angiogenesis full-thickness wounds. To further explain therapeutic effect EpiSCs, EpiSC–derived exosomes (EpiSC-EXOs) are considered main substance contributing to cell effectivity. In our study, EpiSCs and EpiSC-EXOs were supplied dorsal wounds db/db mice. Results showed could colonize area both...
Skin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role skin diseases developments. We conducted Mendelian randomization study determine causal association between fibrosis.
Diabetic foot ulcer is a common and serious complication of diabetes, with high risk amputation, recurrence, mortality. Aiming at the characteristics diabetic wounds based on result network pharmacology, tailored ligand cyanidin-3-O-glucoside (C3G) was selected to construct metal-phenolic (CM) through self-assembly reaction manganese ions. CM integrates pharmacological advantages C3G in antidiabetes anti-inflammatory activity networks by simulating metal coordination structure antioxidant...
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target...
Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role...
Abstract: Nanoparticles have an enormous potential for development in biomedical applications, such as gene or drug delivery. We developed and characterized aminopropyltriethoxysilane-functionalized silicon dioxide nanoparticles (APTES-SiNPs) therapy. Lipofectamine ® 2000, a commonly used agent, served contrast. showed that APTES-SiNPs had transfection efficiency almost equal to of but with lower cytotoxicity. Thus, these novel can achieve highly efficient plasmid DNA, some extent reduce...
C-type lectin receptors (CLRs) such as Dectin-2 function pattern recognition to sense fungal infection. However, the signaling pathways induced by these remain largely unknown. Previous studies suggest that CLR-induced pathway may utilize similar components B cell receptor-induced pathway. Phospholipase Cγ2 (PLCγ2) is a key component in receptor signaling, but its role other has not been fully characterized. Here, we show PLCγ2 functions downstream of response stimulation hyphal form Candida...
BackgroundKeloid and hypertrophic scar (HS) are two pathological forms of excessive dermal fibrosis, which due to aberrant wound‐healing responses. Accumulating evidence suggests that activity growth factors increased numbers factor receptors play an important role in the formation scar.