IMPORTANCE Myopia has reached epidemic levels in parts of East and Southeast Asia.However, there is no effective intervention to prevent the development myopia.OBJECTIVE To assess efficacy increasing time spent outdoors at school preventing incident myopia.

Atomically dispersed supported metal catalysts are drawing wide attention because of the opportunities they offer for new catalytic properties combined with efficient use metals. We extend this class materials to that incorporate atomically atoms as promoters. The used challenging nitroarene hydrogenation and found have both high activity selectivity. promoters single-site Sn on TiO2 supports nanoparticle catalysts. Represented M/Sn-TiO2 (M = Au, Ru, Pt, Ni), these decidedly outperform...

Abstract The higher ethanol titer inevitably requires solids loading during the simultaneous enzymatic saccharification and fermentation (SSF) using lignocellulose as feedstock. mixing between solid liquid enzyme is crucially important. In this study, a bioreactor with novel helical impeller was designed applied to SSF operation of steam explosion pretreated corn stover under different loadings dosages. performances common Rushton were compared analyzed by measuring rheological properties...

Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs). However, the roles of cancer specific lncRNA and its related competitive endogenous (ceRNA) network in hepatocellular cell carcinoma (HCC) are not fully understood. The profiles 372 HCC patients, including tumor 48 adjacent non-tumor liver tissues, from Cancer Genome Atlas (TCGA) NCBI GEO omnibus (GSE65485) were analyzed. lncRNAs (or lncRNAs) identified correlated clinical features. Based on...

Abstract Background Heat and drought are serious threats for crop growth development. As the sixth largest cereal in world, pearl millet can not only be used food forage but also as a source of bioenergy. Pearl is highly tolerant to heat drought. Given this, it considered an ideal study plant stress tolerance identify heat-resistant genes. Results In this study, we Pacbio sequencing data reference sequence analyze Illumina that had been subjected 48 h. By summarizing previous studies, found...

Sex chromosome have evolved independently in numerous lineages across the tree of life, both diploid-dominant species, including many animals and plants, less studied haploid-dominant plants algae. Strict genetic sex determination ensures that individuals reproduce by outcrossing. However, species with separate sexes (termed dioecy diploid dioicy haploid plants) may sometimes evolve different systems, become monoicous, ability to self-fertilize. Here, we study dioicy-monoicy transitions...

Abstract To facilitate developing rice varieties tolerant to salt stress, a panel of 208 mini-core accessions collected from 25 countries were evaluated for 13 traits associated with tolerance (ST) at the germination and seedling stages. The showed tremendous variation all measured ST eight showing high levels either and/or both Using 395,553 SNP markers covering ~372 Mb genome multi-locus mixed linear models, 20 QTN 11 identified by GWAS, including 6 affecting stage 14 stage. integration...

Hepatocellular carcinoma (HCC) is the fifth common cancer. The differential expression of microRNAs (miRNAs) has been associated with prognosis various cancers. However, limited information available regarding genome-wide miRNA profiles in HCC to generate a tumor-specific signature prognostic values. In this study, 327 patients, including tumor and 43 adjacent non-tumor tissues, from Cancer Genome Atlas (TCGA) Liver hepatocellular (LIHC) were analyzed. associations differentially expressed...

Large language models (LLMs) have shown human-level capabilities in solving various complex tasks. However, it is still unknown whether state-of-the-art LLMs master sufficient knowledge related to heating, ventilation and air conditioning (HVAC) systems. It will be inspiring if can think learn like professionals the HVAC industry. Hence, this study investigates performance of on mastering skills industry by letting them take ASHRAE Certified Designer examination, an authoritative examination...

The economy-wide implications of climate change on agricultural sectors in 2050 are estimated using a static computable general equilibrium model. Peculiar to this exercise is the coupling economic model with climatic forecasting temperature increase relevant year and crop-growth estimating impact cereal productivity. main results study point out one hand limited influence world food supply welfare; other its important distributional consequences as stronger negative effects concentrated...

Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased colorectal cancer (CRC). Despite CRC cell growth, cycle and apoptosis not affected by knock-down, knock-down suppressed migration invasion. addition, xenograft animal model suggested that Our results also showed indoleamine 2,3-dioxygenase 1 (IDO1) reduced therefore...

CHOP has been shown to be involved in AF cells apoptosis and disc degeneration a rat model. The aim of this study was investigate the regulatory effects TNF-α on C/EBP homologous protein (CHOP) role nucleus pulposus (NP) cell apoptosis. chop were measured by qPCR, Western blot, immunofluorescence. TNF receptor involvement analyzed small interfering RNA (siRNA), blotting, immunofluorescence, qPCR. NF-κB MAPK TNF-α-mediated promoter activity studied using siRNAs, TNF-α-induced Bcl-2 Bax Flow...

Tumor-associated macrophages (TAMs), a major player in the tumor microenvironment, were recently recognized as potential therapeutic target. To date, very few anticancer drugs or drug-delivery systems designed to target TAMs. Inspired by "eat me" signal, phosphatidylserine (PS), mediated phagocytic clearance of apoptotic bodies, this study, matrix metalloproteinase 2 (MMP2)-sensitive PS-modified nanoparticles developed. In design, PS is externalized nanoparticles' surface only when reach...

Metabolic changes, especially in glucose metabolism, are widely established during the occurrence and development of tumors regarded as biological markers pan-cancer. The well-known ‘Warburg effect’ demonstrates that cancer cells prefer aerobic glycolysis even if there is sufficient ambient oxygen. Accumulating evidence suggests plays a pivotal role colorectal (CRC) development. However, few studies have examined relationship glycolytic gene clusters with prognosis CRC patients. Here, our...

Houttuynia THUNB. (Saururaceae) has been used for dozens of years in China the treatment cough, leucorrhea and ureteritis. The essential oils from two species: emeiensis cordata sold under one trade name 'Yuxingcao', obtained by hydrodistillation, were analyzed GC-MS. results show that fifty-five components identified methyl nonyl ketone (2.10—40.36%), bornyl acetate (0.4—8.61%) β-myrcene (2.58—18.47%) most abundant oil, but percentage compounds different species parts varied greatly. fold...

The quality of botanical food is increasingly assessed by the content multiple bioactive compounds. This study reports, for first time, an HPLC fingerprinting method evaluation Rubus suavissimus leaves possessing bioactivities. Five constituents, gallic acid, rutin, ellagic rubusoside, and steviol monoside, were quantified used in developing qualitative chromatographic fingerprints. limits detection quantification ranged from 0.29 to 37.86 μg/mL. relative standard deviations (RSDs) intra-...

BackgroundKeloid and hypertrophic scar (HS) are two pathological forms of excessive dermal fibrosis, which due to aberrant wound‐healing responses. Accumulating evidence suggests that activity growth factors increased numbers factor receptors play an important role in the formation scar.

Abstract Non-traumatic osteonecrosis of the femoral head (ONFH) is clinically a devastating and progressive disease without an effective treatment. Mesenchymal stem cells (MSCs) transplantation has been used to treat ONFH in early stage, but failure rate this therapy high due reduced osteogenic differentiation migration transplanted MSCs related with pathological bone tissues. However, mechanism responsible for decrease still unclear. Therefore, we assume that implanted might be influenced...

Coal-fired power plays a critical role in China's compliance with the Paris Agreement. This research quantifies stranded coal assets under different capacity expansion scenarios an integrated approach and high-precision coal-fired database. From top-down perspective, firstly, pathway of consistent global 2°C scenario is outlined then those plants are identified bottom-up perspective. Stranded value estimated based upon cash flow algorithm. Results show that if stabilizes during 2020–2030,...