A5101654206- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Sports injuries and prevention
- Bone fractures and treatments
- Bone and Joint Diseases
- Mesenchymal stem cell research
- Foot and Ankle Surgery
- Osteoarthritis Treatment and Mechanisms
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Neurogenetic and Muscular Disorders Research
- Shoulder Injury and Treatment
- Electric and Hybrid Vehicle Technologies
- Peptidase Inhibition and Analysis
- Transgenic Plants and Applications
- Aerodynamics and Fluid Dynamics Research
- Liver Disease Diagnosis and Treatment
- Brake Systems and Friction Analysis
- Nuclear Receptors and Signaling
- CRISPR and Genetic Engineering
- Parvovirus B19 Infection Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetic Foot Ulcer Assessment and Management
- Adhesion, Friction, and Surface Interactions
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2023
Chongqing Medical University
2013-2023
Beijing Administration Institute
2023
Henan University Huaihe Hospital and Huaihe Clinical Institute
2021
University of Baltimore
2018
Johns Hopkins University
2018
Qujing Normal University
2014
Abstract Non-traumatic osteonecrosis of the femoral head (ONFH) is clinically a devastating and progressive disease without an effective treatment. Mesenchymal stem cells (MSCs) transplantation has been used to treat ONFH in early stage, but failure rate this therapy high due reduced osteogenic differentiation migration transplanted MSCs related with pathological bone tissues. However, mechanism responsible for decrease still unclear. Therefore, we assume that implanted might be influenced...
Apelin alleviates oxidative stress which contributes to the development of aging. IVDD is a disease closely correlated aging and known be harmful NP cells' matrix synthesis. The purpose present study was investigate role underlying mechanism in degradation under stress.First, mRNA protein expressions were checked by RT-PCR Western blot from normal degenerative IVD explore relationship between preliminarily. Then, H2O2 used mimic cells. After treated with 13 CQ, GAG content assessed DMMB...
Abstract Inflammation participates in the development of OA and targeting inflammatory signaling pathways is a potential strategy for treatment. IL-1β one most important factors to trigger activation NF-κB accelerate progression, whereas patients could hardly benefit from inhibiting clinic, suggesting importance further explore details inflammation. We here showed that expression miR-18a chondrocytes was specifically induced response vitro as well rat model during which involved,...
To research whether medial PTS, lateral PTS and MTD were different between the PCL injury group intact group.Retrospective case-control study, level of evidence III.Fifty patients with rupture from 2015 to 2020 in our hospital, 50 matched by age sex enrolled study. The intraclass correlation coefficient (ICC) was used assess reliability each parameter. independent t-test conducted identify differences tibial morphometric characteristics PCL-injured PCL-intact individuals, including posterior...
The tibial tubercle (TT)-trochlear groove (TT-TG) distance has low reproducibility in patients with a dysplastic trochlea, whereas the clinical value of TT-posterior cruciate ligament (TT-PCL) remains controversial.To establish method to assess position TT on magnetic resonance imaging (MRI) scans using TT-Roman arch (TT-RA) distance, compare this TT-TG and TT-PCL provide pathological threshold TT-RA patellar dislocation.Cross-sectional study; Level evidence, 3.The were measured MRI 70...
Abstract Enhanced adipogenic differentiation of mesenchymal stem cells (MSCs) is considered as a major risk factor for steroid-induced osteonecrosis the femoral head (SOFNH). The role microRNAs during this process has sparked interest. miR-486-5p expression was down-regulated significantly in bone tissues both SONFH patients and rat models. purpose study to reveal on MSCs adipogenesis progression. present showed that could inhibit 3T3-L1 by suppressing mitotic clonal expansion (MCE). And...
Abstract The ideal procedure for anterior cruciate ligament (ACL) reconstruction is one that can achieve anatomical restoration a better ACL function. This retrospective comparative study was conducted to evaluate the objective and subjective clinical results of conventional single-bundle femoral round (SBR) tunnel technique, oval (SBO) double-bundle (DB) surgical technique with hamstring tendon autografts. Patients who underwent SBO, SBR, DB reconstructions from January 2016 August 2017...
Background: The tibial tubercle to trochlear groove (TT-TG) distance is currently considered as an indication for osteotomy. While the influence of femoral condylar morphology on such measurement remains unclear. Methods: A total 86 patients with patellar dislocation (PD) and healthy individuals were enrolled. Femoral TT-TG measured by anatomical transepicondylar axis (TT-TGa), surgical (TT-TGs), posterior reference line (TT-TGp) assessed MRI. Unpaired t-test, Spearman, Pearson correlation...
Abstract Background A functionally deficient anterior cruciate ligament (ACL) is considered one of the contraindications in unicompartmental knee arthroplasty (UKA). But there still a lack standardized and reproducible methods to assess ACL functional integrity patients with advanced anteromedial osteoarthritis (AMOA). This study explores value passive tibial subluxation (PATS) on axial MRI evaluating status this population. Methods Patients who met UKA indications between November 2017...
A newly formed mandibular condylar cartilage at 9 weeks of gestation (37mm crown rump length) was analyzed immunohistochemically. The cells in and condensed mesenchymal posterior to the showed alkaline phosphatase immunoreactivity, confirming human is also derived from periosteum-like tissue, as demonstrated rodents. simultaneously expresses immunoreactivity for collagen types I II, aggrecan, versican, tenascin-C well hyaluronan staining but not type X. Thus newly-formed has...
Various anatomic abnormalities are implicated in non-contact anterior cruciate ligament (ACL) injury, but researchers rarely deal with the relation between tibial spine height and ACL injury. We conducted a retrospective case-control study to include 96 patients without injuries. Tibial plateau width (TPW), medial lateral (MTSH LTSH), (TSW) were measured by radiographs. The parameters compared among subgroups. Binary regression mode, receiver operating characteristic curves, area under curve...
All the drive motor of AGV are DC servo in domestic stage , but it has some shortcomings such as more power consumption ,noise, magnet coils easy to burn, life is short and so on actual production. Through two series comparative tests AC driven get mode start time, acceleration, top speed other values.Through numerical processing analysis know that a better than Dc motor..
Existing AGV car’s brakes are electromagnet brakes. Brake overheating causes brake damaged during work time.In this paper ,the hydraulic pressure floating caliper is applied to the car . It with electromagnetic for braking performance comparison test, through comparative analysis know that can not only meet requirements and system dynamic has improved greatly.
Abstract Background : The imbalance between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is not only the primary pathological feature but also a major contributor to pathogenesis steroid-induced osteonecrosis femoral head (SONFH). Cellular senescence one main causes imbalanced BMSCs differentiation. purpose this study was reveal whether cellular could participate in progression SONFH related mechanisms. Methods rat model constructed, were extracted....
Abstract Background: Small cell prostate carcinoma (SCPC) is a rare and highly malignant subtype of cancer. SCPC only accounts for 0.5%-2% untreated primary cancer, but can present in up to 25% lethal metastatic cancer autopsies. frequently lacks androgen receptor (AR) specific antigen (PSA) expression, often responds poorly deprivation therapy (ADT). However, the expression pattern different AR isoforms after ADT remains characterized. In this study, we have validated developed new...
Abstract To screen for sensitive drugs recurrent primary liver cancer (PLC) and elucidate the mechanisms underlying inherent acquired drug resistance, we established a platform of organoids, organoids-derived xenograft (ODX) mouse models, patient-derived (PDX) models (PLC). Fifty-two organoids were from 153 PLC patients. Establishing hepatocellular carcinoma (HCC) displayed trend toward higher success rate than establishing PDX (29.0% vs. 23.7%) took shorter duration (13.0 ± 4.7 25.1 5.4...
Abstract Objectives To 1) figure out the difference in tibial morphologies between patients with posterior cruciate ligament (PCL) injury and those without, 2) identify any anatomical variations contributing to PCL rupture. Design Retrospective case-control study, level of evidence III. Methods 45 rupture from 2015 2020 our hospital, matched by age sex intact were enrolled study. The intraclass correlation coefficient (ICC) was used assess reliability each parameter. independent t-test...
Abstract Objectives To 1) figure out the difference in tibial morphologies between patients with posterior cruciate ligament (PCL) injury and those without, 2) identify any anatomical variations contributing to PCL rupture. Design Retrospective case-control study, level of evidence III. Methods 45 rupture from 2015 2020 our hospital, matched by age sex intact were enrolled study. The intraclass correlation coefficient (ICC) was used assess reliability each parameter. independent t-test...
Abstract purpose: To (1) verify the reliability of tibial tubercle-trochlear groove (TT-TG) distance measured by posterior condylar reference line (PCRL), surgical and anatomical transepicondylar axis (SEA AEA) on MRI (TT-TGp, TT-TGs, TT-TGa, respectively), (2) validate diagnostic capacity each parameter, (3) define pathological threshold value TT-TG for tubercle osteotomy (TTO). Methods: 86 patients with patellar dislocation (PD) healthy individuals were included. The intraclass correlation...
Abstract Objectives: To determine the relationship between non-contact anterior cruciate ligament (ACL) injury and tibial spine width or height to verify whither relationships vary from males females. Design: Retrospective case-control study, level of evidence III. Methods: Ninety-six patients with primary ACL injuries 96 intact were recruited in our institution 2017 2019. The divided into male female subgroups. plateauwidth (TPW), medial lateral height(MTSH LTSH, respectively), (TSW)...