A5088321212- Atmospheric chemistry and aerosols
- Atmospheric Ozone and Climate
- Air Quality and Health Impacts
- Atmospheric aerosols and clouds
- Air Quality Monitoring and Forecasting
- Atmospheric and Environmental Gas Dynamics
- Spine and Intervertebral Disc Pathology
- Climate Change and Health Impacts
- Scoliosis diagnosis and treatment
- Oceanographic and Atmospheric Processes
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Birth, Development, and Health
- TGF-β signaling in diseases
- Spinal Fractures and Fixation Techniques
- Hedgehog Signaling Pathway Studies
- Bone Metabolism and Diseases
- Developmental Biology and Gene Regulation
- Radiomics and Machine Learning in Medical Imaging
- Advancements in Transdermal Drug Delivery
- Plant Toxicity and Pharmacological Properties
- PI3K/AKT/mTOR signaling in cancer
- Hippo pathway signaling and YAP/TAZ
China Meteorological Administration
2020-2025
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
South China Sea Institute Of Oceanology
2022
Institute of Oceanology
2022
Institute of Atmospheric Physics
2019
Chinese Academy of Sciences
2019
Institute of Urban Environment
2019
Abnormal mechanical load is a main risk factor of intervertebral disc degeneration (IDD), and cellular senescence pathological change in IDD. In addition, extracellular matrix (ECM) stiffness promotes human nucleus pulposus cells (hNPCs) senescence. However, the molecular mechanism underlying mechano-induced IDD progression not yet fully elucidated. First, we demonstrated that mechano-stress promoted hNPCs via NF-κB signaling. Subsequently, identified periostin as mechano-responsive molecule...
Abstract. The characteristics of ozone variations and the impacts synoptic local meteorological factors in northern China were quantitatively analyzed during warm season from 2013 to 2017 based on multi-city situ data as well reanalysis. domain-averaged maximum daily 8 h running average O3 (MDA8 O3) concentration was 122±11 µg m−3, with an increase rate 7.88 m−3 yr−1, three most polluted months closely related circulation patterns, which occurred June (149 m−3), May (138 m−3) July (132 m−3)....
Abstract The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, single‐cell transcriptomic atlas mapping early IVD formation is still lacking. Here, authors generate spatiotemporal and single cell‐based human at embryonic stage comparative mouse transcript landscape. They identify two novel notochord (NC)/nucleus pulposus (NP) clusters, SRY‐box transcription...
Abstract Background The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. aim this study was to explore the role destruction based on a mouse model. Methods RA-induced OP model mice were established. To assess these mice, micro-CT used characterize trabecular structure normal and those treated with RA (model), + low-dose (Mlt-L), high-dose (Mlt-H), alendronate sodium (positive control). shape bone,...
Abstract The recent 20 years (2000–2019) ozonesonde profiles recorded at the Hong Kong Observatory are analyzed to study Tropospheric Ozone (TropO 3 ) variability over Kong, South China. TropO described without constraints of traditional monthly averages; they clustered based on a Self‐Organizing Map (SOM) explore short‐term variability, and separated into two 10‐year periods investigate long‐term pooled statistical analysis. roles precursor emissions, dynamic transport, photochemical...
Osteoarthritis (OA) is an age-related or post-traumatic degenerative whole joint disease characterized by the rupture of articular cartilage homeostasis, regulatory mechanisms which remain elusive. This study identifies essential role heterogeneous nuclear ribonucleoprotein K (hnRNPK) in maintaining homeostasis. Hnrnpk expression markedly downregulated human and mice OA cartilage. The deletion effectively accelerates development age-dependent mice. Mechanistically, KH1 KH2 domain bind...
A self-amplifying and propagating loop of YAP-SHH is a core molecular mechanism underlying diverse forms heterotopic ossification.
Most existing vaccines, delivered by intramuscular injection (IM), are typically associated with stringent storage requirements under cold-chain distribution and professional administration medical personnel often result in the induction of weak mucosal immunity. In this context, we reported a microneedle (MN) patch to deliver chitosan oligosaccharide (COS)-encapsulated DNA vaccines (DNA@COS) encoding spike nucleocapsid proteins SARS-CoV-2 as vaccination technology. Compared IM immunization,...
Abstract. Traditional tropospheric ozone (O3) climatology uses a simple average substantially smoothed stratification structure in individual O3 profiles, limiting our ability to properly describe and understand how is vertically distributed at the interface between mixing layer (ML) free troposphere (FT). In this study, we collected 1897 ozonesonde profiles from two Chinese megacities (Beijing Hong Kong) over period 2000–2022 investigate climatological vertical heterogeneity of...
Abstract Purpose The Lenke classification system is widely utilized as the preoperative evaluation protocol for adolescent idiopathic scoliosis (AIS). However, manual measurement susceptible to observer‐induced variability, which consequently impacts of progression. goal this investigation was develop an automated utilizing innovative deep learning algorithms. Methods Using database from First Affiliated Hospital Sun Yat‐sen University, whole spinal x‐rays images were retrospectively...
Hydrogen peroxide (H2O2) plays a key role in atmospheric chemistry, but knowledge of its variation, sources, and impact on sulfate formation remains incomplete, especially the urban boundary layer aloft. Here, we conducted field campaign with measurements H2O2 related species at tower-based site (∼528 m above ground surface) Beijing spring 2022. The observed hourly concentration reached up to 21.2 ppbv an average value 3.4 ± 3.7 during entire observation period, which was higher than values...
Abstract This paper introduces the DISRELCUB (Direct In- situ Study of REsidual Layer Chemistry in Urban Beijing) experiment conducted on roof CITIC (China International Trust and Investment Corporation) Tower, which stands 528 m above ground urban Beijing. The aim is to directly study in-situ residual layer chemistry its influence air quality surface. experiments were performed during March-April 2022 2024, respectively. For first time, we can present a picture nano-particle formation...
Abstract. Understanding stratospheric intrusion (SI) is crucial for elucidating atmospheric complexities and improving strategies to mitigate surface ozone (O3) pollution. This study investigates a deep trough-induced SI event in China from June 10 13, 2013, based on ozonesondes Beijing, Changchun, Hong Kong, nationwide ground-based measurements, fully-validated reanalysis products. Ozonesondes Beijing indicated notable high-level secondary peaks (> 400 ppbv) since 11. Tropospheric...
Abstract The heterogeneous hydrolysis of dinitrogen pentoxide (N 2 O 5 ) is an important pathway in nitrate formation; however, its formation rate and relative contribution to total particulate () are highly variable. Here we report that nocturnal via N dependent on the regime defined by ratio NO 3 . Nocturnal suppressed ‐limited but enhanced a regime. results have crucial implications for effective control pollution future. An exclusive decrease will may be less or even increase
Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been identified. However, the mechanism underlying effects of mutations remain unknown.Human mesenchymal stem cells (hMSCs) were isolated from both patients and healthy volunteer donors, expression was detected by western blotting real-time quantitative PCR (RT-qPCR). Zebrafish embryos injected with mapk7 morpholinos or co-injected wild-type (WT) messenger RNA (mRNA) at one-cell stage,...