A5103275612- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Gas Sensing Nanomaterials and Sensors
- Protein Structure and Dynamics
- ZnO doping and properties
- Monoclonal and Polyclonal Antibodies Research
- Photochemistry and Electron Transfer Studies
- Spectroscopy and Quantum Chemical Studies
- Luminescence Properties of Advanced Materials
- Titanium Alloys Microstructure and Properties
- Enzyme Structure and Function
- Receptor Mechanisms and Signaling
- Perovskite Materials and Applications
- Thermochemical Biomass Conversion Processes
- Free Radicals and Antioxidants
- Industrial Gas Emission Control
- Solid-state spectroscopy and crystallography
- Endoplasmic Reticulum Stress and Disease
- Intermetallics and Advanced Alloy Properties
- Coal Properties and Utilization
- Genetics, Aging, and Longevity in Model Organisms
- Nanocluster Synthesis and Applications
- Inorganic Fluorides and Related Compounds
- Advanced Chemical Physics Studies
- Carbon and Quantum Dots Applications
Columbia University
2022-2025
Shenyang University of Technology
2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Beijing University of Technology
2024
Wuhan Textile University
2024
Shanghai Institute of Technology
2022-2023
Hefei University of Technology
2023
Beijing University of Chemical Technology
2017-2022
Chinese Academy of Sciences
2006-2022
Intermolecular S···O interactions are very common and important in biological systems, but until recently, the presence of these contacts protein-ligand systems largely depended on serendipitous discovery instead rational design. Here we provide insight into phenomenon intermolecular by focusing three sulfur-containing aromatic rings. Quantum mechanics is employed to characterize strength directionality determine their energy dependence geometric parameters. Protein Data Bank mining...
The glycoprotein hormones of humans, produced in the pituitary and acting through receptors gonads to support reproduction thyroid gland for metabolism, have co-evolved from invertebrate counterparts
Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41) 3 ] that promote virus entry into cell. CD4-mimetic compounds (CD4mcs) comprise small organic molecules bind highly conserved CD4-binding site of gp120 prematurely induce inactivating Env changes, including shedding from trimer. By inducing more “open,” antibody-susceptible conformations, CD4mcs also sensitize virions neutralization by...
In order to investigate function of carrier behavior on gas-sensing properties, tin oxide-based films with different concentration and mobility were obtained, by magnetron sputtering from the powder target, which was followed further oxygen-management though annealing treatment. The microstructure, surface morphology, electrical properties gas sensitivity characterized XRD, Raman spectrum, photoluminescence atomic force microscope, hall effect system electrochemical workstation,...
Coal-fired power plays a critical role in China's compliance with the Paris Agreement. This research quantifies stranded coal assets under different capacity expansion scenarios an integrated approach and high-precision coal-fired database. From top-down perspective, firstly, pathway of consistent global 2°C scenario is outlined then those plants are identified bottom-up perspective. Stranded value estimated based upon cash flow algorithm. Results show that if stabilizes during 2020–2030,...
A magnetic solid phase extraction method based on covalent organic frameworks (TpBD@Fe3 O4 ; 2,4,6-triformylphloroglucinol (Tp) and benzidine (BD)) combined with high performance liquid chromatography has been developed to detect the sulfonamides including sulfadiazine, sulfamerazine, sulfamethazine, sulfamethoxazole in milk meat. TpBD@Fe3 were synthesized at room temperature under mild reaction conditions a simple rapid operation. The exhibited higher efficiency because of π-π electrostatic...
Purpose: Klebsiella pneumoniae is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, presents significant challenges clinical management. Current therapeutic strategies are no longer able to meet the needs; therefore, there an urgent need develop novel strategies. This study aimed evaluate efficacy of phage therapy in treating bacterial infections. Methods: Isolated vB_Kpn_HF0522 morphology were observed using transmission electron microscopy....
The components used in aeroengines are usually affected by both temperature and load. high‐temperature bending fracture caused the combined action of high load is a huge hidden danger. In this article, three‐point test Ti60 alloy rolled sheet carried out. order to improve property alloy, authors carry out vacuum solution aging treatment. microstructure crack propagation behavior observed, studied. results show that strength σ bb treated treatment increased. This because when propagates...
Many protein sequences occupy similar three-dimensional structures known as folds. In nature, folds are well-conserved over the course of evolution, such that there 100,000 times many extant than Despite their common shapes, can adopt wide-ranging functions, raising question: so strongly conserved for purpose maintaining function-driving energetic changes in families? Here we show a set key relationships family bacterial transcription factors (TFs) is using high-resolution hydrogen...
A Ho 3+ :BSO crystal was grown using the Bridgman method. The 2.1 μm CW laser of demonstrated.
Abstract A method coupling liquid chromatography with electrospray ionization time‐of‐flight mass spectrometry (LC/ESI‐TOF/MS) has been developed for rapid and sensitive analysis of rat urinary metabolite profile Danggui Buxue Tang (DBT), a well‐known Chinese herbal formula. After oral administration DBT, urine samples were collected during 0–24 h, then pretreated by solid‐phase extraction. total 68 compounds including 13 parent 55 metabolites detected in the drug‐containing urines compared...
Molecular replacement (MR) is highly effective for biomolecular crystal structure determination, increasingly so as the database of known structures has increased. For candidates without recognizable similarity to structures, however, analyses have nearly always required experiments de novo phase evaluation. Now, with unprecedented accuracy AlphaFold predictions protein from amino-acid sequences, an appreciable expansion reach MR proteins realized. Here, we sought automate -guided procedure...
The Car−Parrinello molecular dynamics (CPMD) method was used to study the dynamic characteristics of cation−π interaction between ammonium and benzene in gaseous aqueous media. results obtained from CPMD calculation on complex state were very similar those calculated Gaussian98 program with DFT MP2 algorithms, demonstrating that is a valid approach for studying this system. Unlike state, our 12-ps simulation showed geometry solution changes frequently terms angles distances. Furthermore,...
The discovery of novel tetrahydropyrrolo[1,2-