A5102262483- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Carbon and Quantum Dots Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Nanocluster Synthesis and Applications
- Quantum Dots Synthesis And Properties
- MXene and MAX Phase Materials
- Dendrimers and Hyperbranched Polymers
- Extracellular vesicles in disease
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Electrochemical Analysis and Applications
- Immune cells in cancer
- Conducting polymers and applications
- Advanced Photocatalysis Techniques
- Molecular Sensors and Ion Detection
- Luminescence Properties of Advanced Materials
- Copper-based nanomaterials and applications
- Covalent Organic Framework Applications
- 2D Materials and Applications
- Catalytic Processes in Materials Science
- Hepatocellular Carcinoma Treatment and Prognosis
Chinese Academy of Sciences
2016-2025
Technical Institute of Physics and Chemistry
2016-2025
Jilin University
2024-2025
State Key Laboratory of Supramolecular Structure and Materials
2024-2025
Yellow River Conservancy Technical Institute
2024
First Hospital of Jilin University
2024
Jilin City Central Hospital
2024
University of Chinese Academy of Sciences
2017-2023
First Hospital of China Medical University
2022
Micron (United States)
2015-2016
Developing functional nanoagents for achieving the combination of microwave dynamic therapy (MDT) and thermal (MTT) is highly desirable due to advantages improving therapeutic effect on tumors minimizing side effects. Metal–organic frameworks (MOFs), as emerging porous materials, exhibit many intriguing properties application in biomedicine. Herein, new-style flexible Mn-doped zirconium metal–organic framework (Mn-ZrMOF) nanocubes (NCs) with average size about 60 nm were prepared easily by a...
Microwave thermotherapy (MWT) has shown great potential in cancer treatment due to its deep tissue penetration and minimally invasive nature. However, the poor microwave absorption (MA) properties of thermal sensitizer medical frequency band significantly limit effect MWT then weaken therapeutic efficacy. In this paper, a Ni-based multilayer heterointerface nanomissile MOFs-Ni-Ru@COFs (MNRC) with improved MA performance desired via introducing magnetic loss dielectric is developed for...
Herein, an effective strategy for designing a new type of nanozyme, blue fluorescent laccase mimics, is reported. Active copper-containing carbon dots (Cu-CDs) were synthesized through simple, nontoxic and one-pot hydrothermal method, which showed favorable photoluminescence properties good photostability under high-salt conditions or in broad pH range (3.0-13.5). The Cu-CDs possessed intrinsic laccase-like activities could catalyze the oxidation substrate p-phenylenediamine (PPD) to produce...
The cytotoxic reactive oxygen species (ROS) generated by photoactivated sensitizers have been well explored in tumor therapy for nearly half a century, which is known as photodynamic (PDT). poor light penetration depth severely hinders PDT primary or adjuvant clinical indication. Whereas microwaves (MWs) are advantageous deep depth, the MW energy considerably lower than that required activation of any to induce ROS generation. Herein we find liquid metal (LM) supernanoparticles activated...
Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor efficiency has great potential in basic researches. A brand‐new MoS 2 nanostructure is designed fabricated, i.e., layered hollow spheres (LMHSs) strong absorption near‐infrared region (NIR) high conversion a simple fast chemical aerosol flow method. Owing curving spherical structure, as‐prepared LMHSs exhibit unique electronic properties comparing nanosheets. In vitro...
There are acknowledged risks of metastasis cancer cells and obstructing treatment from hypoxia. In this work, we design a multifunctional nanocomposite for treating hypoxia based on the oxygen release capability CuO triggered by microwave (MW). Core-shell CuO@ZrO2 nanocomposites prepared confining nanoparticles within cavities mesoporous ZrO2 hollow nanospheres. 1-Butyl-3-methylimidazolium hexafluorophosphate (IL) is loaded to improving thermal therapy (MWTT). 1-Tetradecanol (PCM) introduced...
The zeolitic imidazolate framework-8 (ZIF-8) is a specifically promising drug carrier due to its excellent intrinsic properties. However, the high toxicity of ZIF-8 nanoparticles severely limits their further research and clinical application. In this work, biocompatibility greatly improved by coating ZrO2 onto surface. survival rate cells mice in ZIF-8@ZrO2 nanocomposite group significantly increased compared with undecorated nanoparticle group. Doxorubicin (DOX) as chemotherapeutic...
Hepatocellular carcinoma (HCC) with metastatic disease is associated a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective local but limited for patients distant metastasis. In this study, the efficacy, specificity, safety of P-selectin targeted delivery microwave (MW) responsive drug release investigated development HCC therapy. By encapsulating doxorubicin (DOX) MW sensitizer...
Abstract Backgrounds Microwave sensitization nanoplatform, integrating multiple functional units for improving tumor selectivity, is of great significance clinical microwave treatment. Lanthanide europium metal organic framework (EuMOF) expected to be a theranostic nanoplatform owing its unique luminescent and properties. However, it difficult applied complicated biological systems EuMOF due rapid degradation induced by the solvent molecular ionic environment. In this work, nanocomposite...
Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone gas. However, microwave (MW) not selective against tumors, residual tumors after incomplete ablation will generate immunosuppression, ultimately making prone to recurrence metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) proposed reverse immunosuppression reactivate antitumor...
Abstract Microwave thermal therapy (MWTT) is a novel clinical treatment of tumors via inducing effect and anti‐tumor immune response, exhibiting advantages deep penetration, minimal invasion, high heat conversion efficiency. However, effective ablation difficult to cover the entire tumor area, heat‐shock protein 90 (HSP90) often upregulated after generate tolerance sublethal weaken induced antitumor effect, resulting in rate recurrence metastasis. Herein, multifunctional nanoregulator metal...
An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined targeting, imaging stimulus-responsive release properties into one system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) pharmaceutical drugs were simultaneously incorporated nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface behaviors. The showed strong...
An easily prepared fluorescent Ag nanoclusters (Ag NCs) probe for the sensitive and selective detection of Hg2+ Cu2+ ions was developed here. The NCs were synthesized by using polymethacrylic acid sodium salt as a template via convenient hydrothermal process. as-prepared monodispersed, uniform less than 2 nm in diameter, can be quenched presence mercury (Hg2+) or copper (Cu2+) ions. Excellent linear relationships existed between quenching degree concentrations range 10 nM to 20 μM 30 μM,...
An artificial enzymatic cascade system with high activity and stability is engineered based on Fe3O4–Au@mesoporous SiO2 (MS) microspheres, which possess both intrinsic glucose oxidase (GOx)- peroxidase-mimic activities.
Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as susceptible agent is introduced for enhancing selectivity targeting MWTT. ILs/PDA nanocomposites have an excellent heating efficiency under ultralow power irradiation. Encouraging antitumor effect was observed when tumor bearing mice received...