A5037755296- Synthesis and biological activity
- Porphyrin Metabolism and Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Folate and B Vitamins Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Catalytic C–H Functionalization Methods
- Porphyrin and Phthalocyanine Chemistry
- HIV/AIDS Research and Interventions
- Multicomponent Synthesis of Heterocycles
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and Catalytic Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- HIV-related health complications and treatments
- Hepatitis C virus research
- Lanthanide and Transition Metal Complexes
- Synthesis and Reactivity of Sulfur-Containing Compounds
- HIV, Drug Use, Sexual Risk
- LGBTQ Health, Identity, and Policy
- Hepatitis B Virus Studies
- Catalytic Cross-Coupling Reactions
Zhejiang University
2019-2025
Sun Yat-sen University
2019-2022
University of Science and Technology of China
2014-2022
Hospital of Stomatology, Sun Yat-sen University
2021
Quzhou University
2021
Qingdao University
2006-2021
Affiliated Hospital of Qingdao University
2021
WuXi AppTec (China)
2017
University of Liverpool
2013-2014
Hefei University
2014
Based on enantiopure S- or R-(1-phenylethylamino)methylphosphonic acid (pempH(2)), homochiral lanthanide phosphonates (S)-[Ln(pempH)(NO(3))(2)(H(2)O)(2)] (S-Ln) and (R)-[Ln(pempH)(NO(3))(2)(H(2)O)(2)] (R-Ln) (Ln = Eu, Tb, Ho) are obtained successfully. All six compounds isostructural, showing chiral brick-wall-shaped layer structures. They all optically active, exhibiting second harmonic generation responses 0.7 times that of urea. The Eu Tb display strong red green luminescent properties,...
This paper introduces a novel mathematical model designed to determine combustion characteristics across the length of zone, underpinned by logical theoretical foundations and demonstrating notable alignment with experimental findings. The facilitates calculation efficiency based on inlet flow parameters (temperature, pressure, velocity, length, porosity, air excess ratio), achieving efficiencies beyond conventional limits (η = 0.98–0.99) reaching high values 0.999–0.9999), which is crucial...
The traditional form of a water town is the result combination urban history, culture, and spatial structure. This study digitized historical maps ancient Wenzhou City from four developmental periods (1566, 1765, 1876, 1949); employed space syntax to compute integration, choice, intelligibility road networks; categorized annotated architecturally functional attributes city using geographic information systems software. findings indicate that (1) City’s morphological development gradually...
A fortified vitamin: new class of vitamin B12 mimics with a peptide backbone has been developed (see structure). The choice an appropriate linker between the corrin macrocycle and dimethylbenzimidazole base makes it possible to modulate selectively coordination redox properties at metal center. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please...
The first example of palladium-catalyzed ortho-C-H arylation aryl and benzyl Weinreb amides was developed, in which HOTf used as a key promoter. This method exhibits good functional group tolerance, broad substrate scope both iodides, high mono-selectivity mild reaction conditions.
The sophisticated and efficient delivery of vitamin B12 ("B12") into cells offers promise for B12-bioconjugates in medicinal diagnosis therapy. It is therefore surprising that rather little attention presently paid to an alternative strategy drug design: the development structurally perfect, but catalytically inactive semi-artificial surrogates. Vitamin cofactors catalyse important biological transformations are indispensible humans most other forms life. This strong metabolic dependency...
The discovery of novel tetrahydropyrrolo[1,2-
Abstract A new backbone‐modified vitamin B12 derivative with an unusual configuration at the cobalt center has been used for identification of two axial diastereomers cyano–aqua cobinamides (Cbi) by using 1 H NMR spectroscopy.
Artificial influence: We describe a semi-artificial adenosylpeptide B12 that behaves as cofactor in B12-dependent enzymatic reactions and demonstrate the peptide backbone influences its chemical properties modulates bioactivity vitro vivo. Inhibition of growth L. delbrueckii is demonstrated, thus providing potentially powerful approach for development antibacterial antiproliferative compounds. Detailed facts importance to specialist readers are published "Supporting Information". Such...
This short communication describes the screening of various metal salts for preparation cyano-aqua cobinamides from vitamin B12 in methanol. ZnCl 2 and Cu(NO 3 ) ·3H O have been identified as most active this purpose represent useful alternatives to widely applied Ce(III) method that requires excess cyanide.
An iron-catalyzed one-pot three-component reaction of 1-substituted benzimidazoles with diazoacetates and electron-deficient alkynes or alkenes has been reported. Mechanistically, the goes through a 1,3-dipolar cycloaddition catalytically generated benzimidazolium N-ylides various activated alkenes, leading to multi-substituted polycyclic fused pyrrole derivatives, respectively.
Abstract Coenzyme B 12 can assist radical enzymes that accomplish the vicinal interchange of a hydrogen atom with functional group. It has been proposed CoC bond homolysis coenzyme to cob(II)alamin and 5′‐deoxyadenosyl is aided by bonding corrin C19H 3′‐O ribose moiety incipient radical, which stabilized 30 kJ mol −1 (B. Durbeej et al., Chem. Eur. J. 2009 , 15 8578–8585). The diastereoisomers ( R )‐ S )‐2,3‐dihydroxypropylcobalamin were used as models for . A downfield shift NMR signal...
Chiral enamine N-oxides have been synthesised by a diastereoselective intermolecular reverse-Cope cycloaddition reaction between chiral hydroxylamines and activated acetylenes. Their structures investigated NMR, X-ray crystallography computational methods.
β-Ga2O3 Schottky barrier diodes with field plate (FP-SBDs) are fabricated and their SPICE-compatible model constructed for double-pulse test circuit DC-DC boost converter simulations. The reverse recovery time (trr) of the SBD is 8.8 ns its charge (Qrr) 8.33 nC when switching from a forward current 1 A to bias voltage 100 V di/dt 400 A/μs, which analogous prediction our model. Device radius 500 μm was fabricated, 2 can be obtained at V, meanwhile, breakdown 467 V. Ga2O3-based module after...
Electrospray ionization/ mass spectrometry (ESI/MS) experiments were performed on several polyaromatic sulfur heterocycles (PASH) in the presence of Pd(II) order to promote charge transfer and radical cation formation. Critical experimental parameters, i.e., Pd(II)/organosulfur mole ratio, effect hydrocarbon interferences sample solution flow rate, MS2 collision energy, optimized. PASH compounds a spiked hydrogenated oil then identified determine matrix effects. Selected peaks from...
A bifunctional molecular linker containing both aryl diazonium and trioxolane groups was synthesised its ability to sequentially functionalise glassy carbon covalently immobilise heme investigated. Functionalisation demonstrated by electrochemical techniques.
Abstract Seven novel triazole compounds containing 1,3‐dithiolane groups were synthesized according to the biological isosterism. Their structures confirmed by means of elemental analysis, MS, 1 H NMR, IR and X‐ray crystallography. The results preliminary tests showed that all these possess some antifungal plant growth regulatory activities.
Vitamin und Eiweiß: Eine neue Klasse von Vitamin-B12-Mimetika mit einem Peptidrückgrat wurde entwickelt (siehe Struktur). Die Wahl des geeigneten Bindegliedes zwischen dem Corrin-Makrocyclus der Dimethylbenzimidazol-Base ermöglicht die gezielte Veränderung Koordinations- Redoxeigenschaften Metallzentrums. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...
Abstract Background Mental health problems (e.g., depression and anxiety) are among the most commonly reported comorbidities of HIV. Antiretroviral therapy (ART) coverage has increased sharply. The purposes this prospective cohort study were to investigate ART-related experiences whether they associated with mental a sample people living HIV undergoing ART in China. Methods participants 400 who had started for first time Guangzhou city. They followed-up 1-year after initiation. Probable...
This study investigated the prevalence of intention to start antiretroviral therapy (ART) immediately among people living with HIV (PLWH) in China and associated perceptions toward ART based on behavioral theories. The was initiated after launch an expanded strategy. A cross-sectional conducted 450 PLWH who were naive city Guangzhou, China, from June 2016 February 2017. Among participants, 311 (69.1%) showed immediately. summary logistic regression analysis indicated that significantly...
A Rh-catalyzed selective three-component reaction of diazo compounds with diarylmethanimines and ketimines is reported that offers an efficient convenient access to vicinal diamine derivatives two tertiary stereocenters in high yields.