A5100711908- Glycosylation and Glycoproteins Research
- Advanced Photocatalysis Techniques
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Organometallic Complex Synthesis and Catalysis
- Peptidase Inhibition and Analysis
- Biosensors and Analytical Detection
- Mass Spectrometry Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Electrocatalysts for Energy Conversion
- Concrete and Cement Materials Research
- Concrete Corrosion and Durability
- Synthetic Organic Chemistry Methods
- Nanomaterials for catalytic reactions
- Medical Imaging Techniques and Applications
- Bioactive Natural Diterpenoids Research
- Covalent Organic Framework Applications
- Fibroblast Growth Factor Research
- Chemical Synthesis and Reactions
- Toxic Organic Pollutants Impact
Fudan University
2016-2025
East China University of Science and Technology
2022-2025
Tsinghua University
2015-2024
University Town of Shenzhen
2024
Chengdu University
2024
Zhejiang University
2021-2024
Tsinghua–Berkeley Shenzhen Institute
2024
ZheJiang Institute For Food and Drug Control
2024
Hunan Normal University
2024
Jilin University
2014-2023
The flow chart of the recognition process for N-linked glycopeptide by using a MagG@COF-5 biocomposite.
Magnetic Fe3O4 nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, Fe3O4@Mg-MOF-74 core-shell nanoparticles show effective selective enrichment 441 N-glycosylation sites 418 glycopeptides from 125 glycoproteins in 1 μL human serum.
Protein N-glycosylation is a ubiquitous and important post-translational modification that has been involved in the development progression of series human-related diseases. Until recently, highly selective capturing glycopeptides from complex biosamples was still significant challenging work due to their changeable structures, ultralow abundance, strong ion-suppressing effect. Here we first report preparation characterization novel, hydrophilic, porous biocomposite composed magnetic...
Capturing glycopeptides selectively and efficiently from mixed biological samples has always been critical for comprehensive in-depth glycoproteomics analysis, but the lack of materials with superior capture capacity high specificity still makes it a challenge. In this work, we introduce way first to synthesize novel boronic-acid-functionalized magnetic graphene@phenolic-formaldehyde resin multilayer composites via facile process. The as-prepared gathered excellent characters large specific...
As a low-end computed tomography (CT) system, translational CT (TCT) is in urgent demand developing countries. Under some circumstances, order to reduce the scan time, decrease X-ray radiation or long objects, furthermore, avoid inconsistency of detector for large angle scanning, we use limited-angle TCT scanning mode an object within limited angular range. However, this introduces additional noise and artifacts that seriously degrade imaging quality affect diagnosis accuracy. To reconstruct...
Large language models (LLMs) have shown human-level capabilities in solving various complex tasks. However, it is still unknown whether state-of-the-art LLMs master sufficient knowledge related to heating, ventilation and air conditioning (HVAC) systems. It will be inspiring if can think learn like professionals the HVAC industry. Hence, this study investigates performance of on mastering skills industry by letting them take ASHRAE Certified Designer examination, an authoritative examination...
This contribution describes the synthesis and polymerization characteristics of covalently linked heterobinuclear constrained-geometry catalyst (μ-CH2CH2-3,3'){(η5-indenyl)[1-Me2Si(tBuN)](TiMe2)}{(η5-indenyl)[1-Me2Si(tBuN)](ZrMe2)} (Ti1Zr1). When activated with Ph3C+B(C6F5)-4, itis competent to produce long-chain (≥C6) branched polyethylenes in ethylene homopolymerization, sharp contrast control experiments mixtures analogous but mononuclear Zr Ti CGC catalysts.
Abstract A nickel‐catalyzed cross‐coupling reaction of glycosyl chlorides with aryl bromides has been developed. The proceeds smoothly under visible‐light irradiation and features the use bench‐stable chlorides, allowing highly stereoselective synthesis C ‐aryl glycosides. magnified image
Extracellular vesicles (EVs) are an excellent candidate for noninvasive diagnostic and prognostic assessments liquid biopsy applications owing to reflecting the dynamic changes of pathological physiological states in body exceptional stability vivo. Herein, we developed a single-extracellular vesicle fluorescence visualization counting platform containing three parts nanoliter-liquid operating aspirating sample, antibody-functionalized coverslip capturing targeted EVs, single-molecule...
Mycotoxins contribute considerably to food losses and pose serious health risks humans animals. This study investigated the mechanisms underlying elimination of mycotoxin zearalenone (ZEN) by a yeast strain, Rhodotorula dairenensis ZDY342B, which was isolated from feces ZEN-treated mice. Isotope-labeled 13C18-ZEN employed for accurately tracking degradation products ZEN, chemical composition cells characterized before after ZEN elimination. The results these analyses confirmed that strain...
This contribution describes the catalytic effect observed by opening coordination sphere at an organoactinide complex. Replacing pentamethylcyclopentadienyl ligand in Cp*2ThCl2 (Cp* = C5Me5) bridge ligation [Me2SiCp' '2]2-2[Li]+ (Cp' ' C5Me4) affords synthesis of ansa-Me2SiCp' '2ThCl2. The X-ray structure this bridged complex coordinated to LiCl salt and solvent is presented, indicating large coordinative unsaturation organoactinides. dichloro reacts with 2 equiv BuLi, affording...
Using effect directed analysis, the presence of estrogenic components in untreated and biologically treated oil sands process water (OSPW) was detected with yeast screening assay after fractionation solid phase extraction followed by reversed high performance liquid chromatography. Comparison composition, as determined electrospray ionization combined high-resolution linear trap quadropole (LTQ)-Orbitrap Velos Pro hybrid mass spectrometry (negative ion) selected nonestrogenic fractions...
In recent MS-based glycoproteomics, the selective enrichment of glycopeptides from complex biological samples is essential. this work, for first time, a novel ultra hydrophilic dendrimer-modified magnetic graphene@polydopamine@poly(amidoamine) (magG@PDA@PAMAM) was synthesized via three simple and rapid steps. The composites combined large surface graphene, strong responsiveness Fe3O4 with double abilities PDA PAMAM. Especially PAMAM had long dendritic chains abundant amino groups. When it...
Analysis of protein glycosylation remains a significant challenge due to the low abundance glycoproteins or N‐glycopeptides. Here we have synthesized an amino‐functionalized metal‐organic framework (MOF) MIL‐101(Cr)‐NH 2 whose surface is grafted with hydrophilic dendrimer poly(amidoamine) (PAMAM) for N‐glycopeptide enrichment based on interactions. The selected substrate MOF MIL‐101(Cr) owns high area which provides nice support peptide adsorption. In addition, displayed good property after...