A5032121600- Gut microbiota and health
- Hydrocarbon exploration and reservoir analysis
- Petroleum Processing and Analysis
- Effects and risks of endocrine disrupting chemicals
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Enhanced Oil Recovery Techniques
- Insect and Pesticide Research
- Toxic Organic Pollutants Impact
- Tryptophan and brain disorders
- Weed Control and Herbicide Applications
- Pesticide and Herbicide Environmental Studies
- Pesticide Exposure and Toxicity
- Nutritional Studies and Diet
- Microbial Community Ecology and Physiology
- Metabolism and Genetic Disorders
- Ruminant Nutrition and Digestive Physiology
- Neurological Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Animal testing and alternatives
- Allelopathy and phytotoxic interactions
- Legionella and Acanthamoeba research
- Analytical chemistry methods development
- Angiogenesis and VEGF in Cancer
- Immunotoxicology and immune responses
Zhejiang University of Technology
2018-2024
Queen's University
2014-2018
University of Alberta
2015
Shanghai Jiao Tong University
2011
(Background): Alzheimer's disease (AD), clinically characterized by the progressive neurodegenerative condition and cognitive impairment, is one of main causes disability in elder people worldwide. Recently, several animal studies indicated that 'gut-brain' axis might contribute to amyloid deposition AD. However, data about gut dysbiosis human AD remains scarce literature, especially including whole process In this prospective cross-sectional study, we aimed at identifying differences...
Intimate metabolic host–microbiome crosstalk regulates immune, metabolic, and neuronal response in health disease, yet remains untapped for biomarkers or intervention disease. Our recent study identified an altered microbiome patients with pre-onset amnestic mild cognitive impairment (aMCI) dementia Alzheimer’s disease (AD). Thus, we aimed to characterize the gut microbial metabolites among AD, aMCI, healthy controls (HC). Here, a cohort of 77 individuals (22 27 28 HC) was recruited. With...
In beef cattle, production feedstuffs are the largest variable input cost. Beef cattle also have a large carbon footprint, raising concern about their environmental impact. Unfortunately, only small proportion of dietary energy is directed toward protein deposition and muscle growth whereas majority supports body maintenance. Improving feed efficiency would, therefore, important consequences on productivity, profitability, sustainability industry. Various measures been proposed to improve...
Polyhalogenated carbazoles (PHCZs) are an emerging class of persistent, bioaccumulative compounds that structurally and chemically related to dioxins. They have been detected widely in sediment, river, soil samples, but their environmental risks largely unknown. Therefore, seven common PHCZs were tested for endocrine disrupting potential silico, vitro, vivo. A dual-luciferase reporter gene assay was used detect receptor-mediated (agonist or antagonistic) activity (concentration range:...
More than 30% of the registered pesticides are chiral with one or more centers and exist as two enantiomers. The frequency chemicals their environmental safety has been considered in risk assessment recent decades. Despite fact that metabolic disturbance is an important sensitive molecular initiating event toxicology effects, potential mechanisms how compounds affect metabolism phenotypes organisms remain unclear. As a typical pesticide, metalaxyl acylalanine fungicide systemic function....
Bisphenol analogues including bisphenol A (BPA), AF (BPAF), F (BPF), and S (BPS) share similar chemical structures endocrine disrupting effects. Their effects on metabolisms, however, are so far only marginally understood. In this study, NMR-based metabonomic profiles of HepG2 cell culture media PCR array were used to assess the metabolomics disturbances gene expression levels in response four BPs (BPA, BPAF, BPF, BPS). The results indicated that BP resulted 7–15 metabolites classified as...
Using effect directed analysis, the presence of estrogenic components in untreated and biologically treated oil sands process water (OSPW) was detected with yeast screening assay after fractionation solid phase extraction followed by reversed high performance liquid chromatography. Comparison composition, as determined electrospray ionization combined high-resolution linear trap quadropole (LTQ)-Orbitrap Velos Pro hybrid mass spectrometry (negative ion) selected nonestrogenic fractions...
Anxiety is one of the complications metabolic disorders (MDs). Obeticholic acid (OCA), bile acids (BAs) derivative, a promising agent for improving MDs in association with gut dysbiosis. Yet, its protective effect on MDs-driven anxiety remains unknown. Here, we assessed serum biochemical parameters and behavioral performance by open field Morris water maze tests HFHS diet-induced mice after OCA intervention nine 18 weeks. Moreover, antibiotics microbial depletion was conducted...
The chirality of pesticides has emerged as an important issue in pesticide design and applications because enantiomers can differ greatly their environmental fate risk. Despite the increasing concern over unintended effects inactive or less effective enantiomers, massive amounts chiral are applied racemic mixtures. As a potential substitute for glyphosate, market glufosinate is expected to grow rapidly. However, very little information available on its enantioselective efficacy-risk...
Polyhalogenated carbazoles (PHCZs) have been widely accepted as emerging pollutants, whereas their ecological and health risks remain uncertain. Herein, female male Sprague-Dawley (SD) mice were treated with four typical PHCZs to investigate negative consequences, along alternations in gut microbiota indicate underlying mechanisms. In mice, the relative liver weight ratio increased after exposure; 2-bromocarbazole (2-BCZ) urine glucose level; 3-bromocarbazole (3-BCZ) decreased total...
Neovascular age-related macular degeneration (nAMD) is a common and multifactorial disease in the elderly that may lead to irreversible vision loss; yet pathogenesis of AMD remains unclear. In this study, nontargeted metabolomics profiling using ultra-performance liquid chromatography coupled with Q-Exactive Orbitrap mass spectrometry was applied discover metabolic feature differences both faeces serum samples between Chinese nonobese subjects without nAMD. faecal samples, total 18...