A5100657179- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- RNA modifications and cancer
- Respiratory Support and Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Toxic Organic Pollutants Impact
- Pesticide and Herbicide Environmental Studies
- S100 Proteins and Annexins
- Pharmaceutical and Antibiotic Environmental Impacts
- Mesenchymal stem cell research
- Hydrogen's biological and therapeutic effects
- Transplantation: Methods and Outcomes
- Inflammation biomarkers and pathways
- Fungal Biology and Applications
- Chromatin Remodeling and Cancer
- Analytical Chemistry and Chromatography
- Phytochemical Studies and Bioactivities
- Extracellular vesicles in disease
Zunyi Medical University
2019-2025
Hebei University
2024
Third People's Hospital of Hangzhou
2021
Zhejiang University of Technology
2016-2020
Affiliated Hospital of Zunyi Medical College
2013-2019
Baoding People's Hospital
2018-2019
Dongguan People’s Hospital
2013
Jiangsu Ocean University
2006
Yantai University
2006
The ecological and health risk assessment of environmental pesticide residues have attracted ever-growing attention; however, their transformation products (TPs) seldom been considered. Herein, we examined the endocrine-disrupting effects 4 widely used pesticides as pyriproxyfen (Pyr), malathion (ML), benalaxyl (BX), fenoxaprop-ethyl (FE), together with 21 TPs through in vitro silico approaches, found approximately 50% exhibited stronger than corresponding parent compounds. Specifically, Pyr...
Polyhalogenated carbazoles (PHCZs) are an emerging class of persistent, bioaccumulative compounds that structurally and chemically related to dioxins. They have been detected widely in sediment, river, soil samples, but their environmental risks largely unknown. Therefore, seven common PHCZs were tested for endocrine disrupting potential silico, vitro, vivo. A dual-luciferase reporter gene assay was used detect receptor-mediated (agonist or antagonistic) activity (concentration range:...
Hyperoxia‑induced acute lung injury (HALI) as one of the most common complications in patents on mechanical ventilation, and there are no efficient methods to overcome this at present. It was hypothesized that microRNA 21‑5p(miR‑21‑5p) can promote survival type II alveolar epithelial cells (AECII), alleviating HALI. The present study aimed combine gene chip analysis with overexpression miR‑21‑5p develop a novel therapeutic option for found AECII apoptosis an important pathogenic event...
Inhibiting apoptosis of type II alveolar epithelial cells (AEC II) is an effective way to decrease hyperoxic acute lung injury (HALI); however, the specific underlying molecular mechanisms have not yet been fully elucidated. Although miRNA‑21‑5p has previously reported H2O2‑induced AEC by targeting PTEN in vitro, whether miR‑21‑5p can HALI vivo and downstream remain unclear. In present study, rats were endotracheally administered with miR‑21‑5p‑encoding (AAV‑6‑miR‑21‑5p) or a negative...
Abstract Oxygen therapy is a crucial medical intervention, but it undeniable that can lead to lung damage. The mTOR pathway plays pivotal role in governing cell survival, including autophagy and apoptosis, two phenomena deeply entwined with the evolution of diseases. However, unclarified whether involved hyperoxic acute injury (HALI). current study aims clarify molecular mechanism underlying pathogenesis HALI by constructing vitro vivo models using H 2 O hyperoxia exposure, respectively. To...
Stable infiltration of myeloid cells, especially tumor-associated M2 macrophages, acts as one the essential features tumor immune microenvironment by promoting malignant progression hepatocellular carcinoma (HCC). However, factors affecting macrophages are not fully understood. In this study, we found molecular subtypes HCC with worst prognosis characterized disorders dominated cell infiltration. Myeloid nuclear differentiation antigen (MNDA) was significantly elevated in most aggressive...
Sepsis is a systemic inflammatory response syndrome and leads to patient's death. Objective: To investigate the effect of myocyte enhancer factor 2 (MEF2C) on acute lung injury (ALI) with sepsis its possible mechanism.The cecal ligation puncture (CLP)-induced rat model was established. The determined by wet-dry weight ratio, concentration cytokines, including tumor necrosis factor-α (TNF-α), Interlukin (IL)-6, IL-1β, IL-10, were measured enzyme-linked-immunosorbent serologic assay kit. cell...
Hyperoxia-induced acute lung injury (HALI) is a severe side effect of refractory hypoxemia treatment, for which no effective therapeutic strategy available. Here, we found that the miR-21-5p level was significantly decreased in rats subjected to hyperoxia. Further, presented evidence crucial regulator mitophagy and mitochondrial dysfunction. Moreover, it proved regulated hyperoxia-induced dysfunction by directly binding target gene PGAM5. In conclusion, first time, could suppress damage...
ObjectiveCerebral vasospasm(CVS) after Subarachnoid hemorrhage (SAH) can cause delayed cerebral ischemia,secondary infarction, and rehemorrhage, which are the leading causes of mutilation death. Nimodipine has been shown to prevent CVS. Magnesium ion (Mg2+) competitively inhibit influx calcium (Ca2+) vasospasm. There is evidence that magnesium sulfate CVS reduce infarct volume SAH. In this study, we evaluated efficacy safety intravenous combined with oral nimodipine on CVS, ischemia,...
To observe and verify the changes of transcriptome in hyperoxia-induced acute lung injury (HALI), to further clarify pathways HALI.
To observe the effect of early intensive blood pressure (BP)-lowering treatment on rebleeding and perihematomal edema (PE) in patients with acute intracerebral hemorrhage (ICH). A total 121 ICH were randomly assigned to an antihypertensive group (IG) (n = 62) or control (CG) 59). For both groups, 25 mg urapidil injection was slowly administered intravenously 6 hours onset. IG, 100 30 mL 0.9% sodium chloride then administered. Repeat computed tomography imaging performed at 24 hours, 72 day...
Abstract The enantioselective effects of chiral compounds have been the subject extensive studies in recent years due to their important implications for contaminant behavior and risk as well design drug pesticide formulations. potential alterations enantioselectivity, however, still remain elusive from available data suggesting numerous environmental factors coexisting achiral compounds. Herein we studied effect nonylphenol (NP), a ubiquitous ingredient formulation, on enantioselectivity...
To screen type II alveolar epithelial cell (AECII) apoptosis related microRNA (miRNA) with gene chip technology, provide a new strategy for the prevention and treatment of hyperoxia-induced acute lung injury(HALI).AECII male Sprague-Dawley (SD) rats was primarily cultured 36 hours, then exposed to 0.5 mmol/L H2O2 establish model. Transmission electron microscope (TEM) used identify AECII observe morphology. Before after injury 2.5, 6, 12 24 fluorescence-activated sorting (FACS) employed...
Hyperoxia-induced acute lung injury (HALI) is a complication to ventilation in patients with respiratory failure, which can lead inflammatory and chronic disease. The aim of this study was integrate bioinformatics analysis identify key genes associated HALI validate their role H
Background Oxygen therapy plays a pivotal role in treating critically ill patients the intensive care unit (ICU). However, excessive oxygen concentrations can precipitate hyperoxia, leading to damage multiple organs, with notable effect on lungs. Hyperoxia condition may lead hyperoxia-induced acute lung injury (HALI), deemed as milder form of respiratory distress syndrome (ARDS). Given its clinical importance and practical implications, there is compelling need investigate underlying...
To investigate whether annexin A1 (ANXA1) improves sepsis-induced lung injury by activating G protein-coupled formyl peptide receptor type 2 (FPR2)-dependent endothelial nitric oxide synthase (eNOS) pathway.
Annexin (ANX), a calcium-phospholipid-binding protein, belongs to superfamily of calcium-dependent membrane phospholipid-binding proteins, which are widely found in prokaryotic and eukaryotic organisms. They classified into five groups: A, B, C, D, E according the different species genera. The family A(ANXA), consists A1-A11 A13, is commonly vertebrates. Previous studies have shown that ANXA involved multiple processes, such as formation biological membranes, establishment ion channels,...
<title>Abstract</title> Background: Although the assessment of in-hospital mortality risk among heart failure patients in intensive care unit (ICU) is crucial for clinical decision-making, there currently a lack comprehensive models accurately predicting their prognosis. Machine learning techniques offer powerful means to identify potential factors and predict outcomes within multivariable data. Methods: This study, based on MIMIC-III database, extracted demographic characteristics, vital...
To study whether wedelolactone can reduce hyperoxia-induced acute lung injury (HALI) by regulating ferroptosis, and provide a basic theoretical basis for the drug treatment of HALI.A total 24 C57BL/6J mice were randomly divided into normal oxygen control group, HALI model group pretreatment with 8 in each group. Mice treated 50 mg/kg intraperitoneally 6 hours, while other two groups not given wedelolactone. After that, was established maintaining content carbon dioxide < 0.5% > 90% molding...
To investigate the effect of overexpression microRNA-21-5p (miR-21-5p) on early apoptosis type II alveolar epithelial cells (AEC II) in rats with hyperoxic acute lung injury (HALI).The Sprague-Dawley (SD) were randomly divided into four groups: control group (CON group), hyperoxia (H (OE group) and empty vector (EV 20 each group. HALI animal model was made by inhaling high concentration oxygen (oxygen ≥ 90%); CON arranged to inhale room air. The miR-21-5p adeno-associated virus-6 (AAV-6)...