A5071721820- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal and related cancers
- Plant-Microbe Interactions and Immunity
- Immune Response and Inflammation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Lysosomal Storage Disorders Research
- Legume Nitrogen Fixing Symbiosis
- Sphingolipid Metabolism and Signaling
- Sperm and Testicular Function
- Neonatal Respiratory Health Research
- Plant Pathogenic Bacteria Studies
- Toxin Mechanisms and Immunotoxins
- Nematode management and characterization studies
- Complement system in diseases
- Graphene research and applications
- Plant Pathogens and Resistance
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antimicrobial Peptides and Activities
- Testicular diseases and treatments
- Invertebrate Immune Response Mechanisms
- Peptidase Inhibition and Analysis
- Plant Stress Responses and Tolerance
- Prenatal Screening and Diagnostics
Memorial Sloan Kettering Cancer Center
2020-2025
Tsinghua University
2003-2019
Hebei University of Engineering
2005-2015
Tianjin University
2012
Abstract Fungal infections by drug-resistant Candida albicans pose a global public health threat. However, the pathogen’s diploid genome greatly hinders genome-wide investigations of resistance mechanisms. Here, we develop an efficient piggyBac transposon-mediated mutagenesis system using stable haploid C. to conduct genetic screens. We find that null mutants in either gene FEN1 or FEN12 (encoding enzymes for synthesis very-long-chain fatty acids as precursors sphingolipids) exhibit...
The activation of both the SA and JA/ETsignalling pathways may lead to more efficient general broad resistance Pst DC3000 by non-pathogenic rhizobacteria. However, mechanisms that govern this simultaneous are unclear. Using Arabidopsis as a model system, two transcription factors, WRKY11 WRKY70, were identified important regulators involved in Induced Systemic Resistance (ISR) triggered Bacillus cereus AR156. results revealed AR156 treatment significantly stimulated but suppressed leaves....
Sertoli cells are essential nurse in the testis that regulate process of spermatogenesis and establish immune-privileged environment blood-testis-barrier (BTB). Here, we report vitro reprogramming fibroblasts to human induced Sertoli-like (hiSCs). Initially, five transcriptional factors a gene reporter carrying AMH promoter were utilized obtain hiSCs. We further reduce number two, NR5A1 GATA4, show these hiSCs have transcriptome profiles cellular properties similar those primary cells....
Activation of various C-type lectin receptors (CLRs) initiates potent proinflammatory responses against microbial infections. However, how activated CLRs are negatively regulated remains unknown. In this study, we report that activation Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination degradation in a Syk-dependent manner. Furthermore, found E3 ubiquitin ligase Casitas B-lineage lymphoma protein b (Cbl-b) mediates the these through associating with each other via...
Abstract In a previous study, we demonstrated the ability of rhizobacterium Bacillus cereus AR156 (AR156) to protect tomato against bacterial wilt caused by Ralstonia solanacearum and root-knot disease Meloidogyne incognita. Here, investigate promote plant growth its role in systemic protection tomatoes cultivated greenhouses speck Pseudomonas syringae pv. DC3000 (DC3000). our experiments, population reached 105–106 CFU/g rhizosphere soil, remained at that level plants for more than 2...
Infection by invasive fungi, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, is one of the leading death causes for increasing population immunocompromised immunodeficient patients. Several C-type lectin receptors (CLRs), including Dectin-1, -2, -3 Mincle can recognize fungal surface components initiate host antifungal immune responses. Nevertheless, it remains to be determined whether other CLRs are involved in immunity. Our recent study suggests that CD23...
Aspergillus fumigatus causes life-threatening mold pneumonia in immunocompromised patients, particularly those with quantitative or qualitative defects neutrophils. Whereas innate immune cell cross-talk licenses neutrophil antifungal activity the lung, role of epithelial cells this process is unknown. Here, we find that surfactant protein C (SPC)–expressing lung integrate infection-induced interleukin-1 and type III interferon signaling to produce granulocyte-macrophage colony-stimulating...
SUMMARY Aspergillus fumigatus causes life-threatening mold pneumonia in immune compromised patients, particularly those with quantitative or qualitative defects neutrophils. While innate cell crosstalk licenses neutrophil antifungal activity the lung, role of epithelial cells this process is unknown. Here, we find that surfactant protein C (SPC)-expressing lung integrate infection-induced IL-1 and type III interferon signaling to produce granulocyte-macrophage colony-stimulating factor...
Nanoporous carbon (NPC)/Ni–P composite membranes were prepared on electroless Ni-plating-modified porous stainless steel tubes (PSSTs) by carbonizing polyimide or cellulose acetate precursors at 700 °C in a nitrogen atmosphere. The performance of the was evaluated single-gas permeation and binary-gas mixture separation. effects substrate with without modification gas studied, diffusion mechanism gases through analyzed. real separation factors mixtures NPC/Ni–P much higher than those...
Aspergillus fumigatus is the most common cause of invasive aspergillosis (IA), a devastating infection in immunocompromised patients. Plasmacytoid dendritic cells (pDCs) regulate host defense against IA by enhancing neutrophil antifungal properties lung. Here, we define pDC activation trajectory during A. and molecular events that underlie protective - crosstalk. Fungus-induced begins after bone marrow egress results pDC-dependent regulation lung type I III IFN levels. These pDC-derived...
Abstract Sertoli cells are essential nurse in the testis that regulate process of spermatogenesis and establish immune-privileged environment blood-testis-barrier (BTB). The induction human from fibroblasts could provide cellular sources for fertility transplantation treatments. Here, we report vitro reprogramming to characterize these induced (hiSCs). Initially, five transcriptional factors (NR5A1, GATA4, WT1, SOX9 DMRT1) a gene reporter carrying AMH promoter were utilized obtain hiSCs. We...
Sertoli cells are essential nurse in the testis that regulate process of spermatogenesis and establish immune-privileged environment blood-testis-barrier (BTB). Here, we report vitro reprogramming human fibroblasts to characterize these induced (hiSCs). Initially, five transcriptional factors (NR5A1, GATA4, WT1, SOX9 DMRT1) a gene reporter carrying AMH promoter were utilized obtain hiSCs. We further reduce number two, i.e., NR5A1 show hiSCs have transcriptome profiles similar those primary...
Summary Aspergillus fumigatus , a ubiquitous mold, is common cause of invasive aspergillosis (IA) in immunocompromised patients. Host defense against IA relies on lung-infiltrating neutrophils and monocyte-derived dendritic cells (Mo-DCs). Here, we demonstrate that plasmacytoid (pDCs), which are prototypically anti-viral cells, participate innate immune crosstalk underlying mucosal antifungal immunity. -infected murine Mo-DCs recruited pDCs to the lung by releasing CXCR3 ligands, CXCL9...