A5071326284- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Immune Response and Inflammation
- Infectious Diseases and Mycology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Immune cells in cancer
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Immune responses and vaccinations
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Plant Pathogens and Fungal Diseases
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Cellular transport and secretion
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2011-2025
Max Planck Institute of Immunobiology and Epigenetics
2024
University of Freiburg
2024
Memorial Hospital
2019-2023
New York Proton Center
2023
Weill Cornell Medicine
2020-2022
Kettering University
2009-2022
University of Washington
2013-2014
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2013-2014
As of 10 April 2020, New York State had 180,458 cases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% deceased individuals1. Population-based studies from China Italy suggested a higher disease 2019 (COVID-19) death rate in patients cancer2,3, although there is knowledge gap as to which aspects its treatment confer risk COVID-194. This information critical balance the competing safety considerations reducing...
Inhalation of fungal spores (conidia) occurs commonly and, in specific circumstances, can result invasive disease. We investigated the murine inflammatory response to conidia Aspergillus fumigatus, most common mold immunocompromised hosts. In contrast dormant spores, germinating induce neutrophil recruitment airways and TNF-alpha/MIP-2 secretion by alveolar macrophages. Fungal beta-glucans act as a trigger for induction these responses through their time-dependent exposure on surface...
Abstract Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of that accumulate during tumor formation, facilitate immune escape, and enable progression. MDSCs important contributors to the development an immunosuppressive microenvironment blocks action cytotoxic antitumor T effector cells. Heterogeneity in these poses significant barrier studying vivo contributions individual MDSC subtypes. Herein, we show granulocyte-macrophage colony stimulating factor, cytokine...
Ibrutinib is a Bruton tyrosine kinase inhibitor that used for the treatment of lymphoid cancers, including chronic lymphocytic leukemia, Waldenström macroglobulinemia, and mantle cell lymphoma. Several case series have described opportunistic infections among ibrutinib recipients, but full extent these unknown. We sought to determine spectrum serious associated with treatment.We reviewed electronic medical records patients cancer at Memorial Sloan Kettering Cancer Center who received during...
Chimeric antigen receptor (CAR)–modified T cells that target the CD19 present a novel promising therapy for treatment of relapsed B-cell acute lymphoblastic leukemia (B-ALL). Although cytokine release syndrome (CRS) and neurotoxicity have emerged as predominant noninfectious complications CAR T-cell therapy, infections associated with this modality not been well documented. We analyzed infectious followed in 53 adult patients B-ALL enrolled phase I clinical trial at Memorial Sloan Kettering...
Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in C-type lectin pathway adaptor protein CARD9 develop spontaneous disease targets central nervous system (CNS). However, how promotes protective antifungal immunity CNS remains unclear. Here, we show a patient with deficiency had impaired neutrophil accumulation induction of neutrophil-recruiting CXC chemokines cerebrospinal fluid despite...
Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model invasive pulmonary aspergillosis (IPA) and 1H-NMR metabolomics, we detected ethanol the lungs mice infected with Aspergillus fumigatus. This result suggests that A. fumigatus exposed to oxygen depleted microenvironments during infection. To test this hypothesis, utilized chemical hypoxia detection agent, pimonidazole hydrochloride, three immunologically...
Alveolar macrophages and neutrophils mediate innate immune defense against the opportunistic fungal pathogen Aspergillus fumigatus are believed to be essential for host survival following inhalation of spores (conidia). Although alveolar postulated kill inhaled conidia act hyphae, relative contribution early A. remain incompletely defined. To more precisely characterize contributions in antifungal defense, we selectively depleted each cell population at different times pulmonary challenge...
We have isolated the cDNA for Rab3D, an additional member of small molecular weight GTP-binding protein family. Rab3D message is abundant in mouse adipocytes. It increased during differentiation 3T3-L1 cells into adipocytes, temporally coincident with appearance insulin-sensitive glucose transporter GLUT4. a close homolog Rab3A, which found on cytoplasmic surface neurosecretory vesicles and may be involved their regulated secretion. Since our previous work showed that permeabilized...
Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in immunocompromised patients. Although -CC-chemokine receptor-2 (CCR2) and Ly6C-expressing inflammatory monocytes (CCR2+Mo) their derivatives initiate adaptive pulmonary immune responses, role coordinating innate responses the lung remain poorly defined. Using conditional antibody-mediated cell ablation strategies, we found CCR2+Mo monocyte-derived dendritic cells (Mo-DCs) are essential for defense...
Pulmonary infection of mice with Aspergillus fumigatus induces concurrent T helper type 1 (Th1) and Th17 responses that depend on Toll-like receptor/MyD88 Dectin-1, respectively. However, the mechanisms balancing Th1 CD4 cell populations during remain incompletely defined. In this study, we show Dectin-1 deficiency disproportionally increases decreases differentiation after A. infection. signaling in fumigatus-infected wild-type reduces IFN-γ IL-12p40 expression lung, thereby decreasing...