A5035885950- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Wound Healing and Treatments
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Ubiquitin and proteasome pathways
- Botanical Research and Applications
- Medicinal Plants and Neuroprotection
- Chemical synthesis and alkaloids
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Electron Spin Resonance Studies
- Nausea and vomiting management
- Nuclear Receptors and Signaling
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
- Laser Applications in Dentistry and Medicine
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Fungal Biology and Applications
- Cerebrovascular and genetic disorders
- Alzheimer's disease research and treatments
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Dalian Medical University
2021-2025
First Affiliated Hospital of Dalian Medical University
2021-2023
In the face of poor prognosis and immunotherapy failure gastric cancer (GC), this project tried to find new potential biomarkers for predicting precision medication ameliorate situation. To form synthetic matrices, we retrieved stomach adenocarcinoma transcriptome data from Genotype-Tissue Expression Project (GTEx) The Cancer Genome Atlas (TCGA). Necroptosis-related prognostic lncRNA was identified by coexpression analysis univariate Cox regression. Then performed least absolute shrinkage...
Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles many lncRNAs in tumor progression remain unclear. In this study, we found that expression lncRNA TP53TG1 was downregulated gastric cancer (GC) and it functioned as a suppressor. addition, low significantly poor survival patients GC. inhibited proliferation, metastasis, cell cycle GC cells, while promoted their apoptosis. m6A modification sites highly abundant on TP53TG1, demethylase ALKBH5...
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. The accumulation of amyloid-beta (Aβ) plaques a distinctive pathological feature AD patients. aims this study were to evaluate therapeutic effect chicoric acid (CA) on models and explore its underlying mechanisms. APPswe/Ind SH-SY5Y cells 5xFAD mice treated with CA. Soluble Aβ1–42 Aβ plaque levels analyzed by ELISA immunohistochemistry, respectively. Transcriptome sequencing was used compare changes in...
Clinical application of doxorubicin is limited because its potential side effects. The present study examined whether naringin had protective actions on doxorubicin-induced liver injury. Male BALB/c mice and alpha mouse 12 (AML-12) cells were used in this paper. results showed that AML-12 treated with significantly reduced cell injury, reactive oxygen species release apoptosis level; Moreover, notably alleviated injury by decreasing aspartate transaminase, alanine transaminase...
Diabetic foot ulcer is a common and serious complication of diabetes, with high risk amputation, recurrence, mortality. Aiming at the characteristics diabetic wounds based on result network pharmacology, tailored ligand cyanidin-3-O-glucoside (C3G) was selected to construct metal-phenolic (CM) through self-assembly reaction manganese ions. CM integrates pharmacological advantages C3G in antidiabetes anti-inflammatory activity networks by simulating metal coordination structure antioxidant...
Strong evidence indicates that remodeling gut microbiota may be an effective approach to combat Parkinson's disease (PD). Scorpion Venom Heat-Resistant Synthesized Peptide (SVHRSP), a synthesized peptide discovered from scorpion venom, displays potent neuroprotection in multiple PD models. However, the potential mechanisms remain unclear. In this study, we demonstrated SVHRSP effectively attenuated gastrointestinal function impairments and reinstated composition rotenone-induced mouse model....
Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role...
Severe acetaminophen (APAP)-induced hepatic damage is the second most common cause for transplantation. Clinically, caused by APAP treated using N-acetyl-L-cysteine, which can induce numerous side effects. Naringin, a bioflavonoid abundant in grapefruit and other citrus fruits, displays marked antiinflammatory antioxidant activities. Herein, we aimed to investigate potential mechanism underlying naringin-mediated protection against APAP-induced acute hepatotoxicity. We observed that naringin...
The hypertrophic scar (HS) is a prevalent cutaneous fibrotic disorder that impacts both the aesthetic and functional aspects of skin, there an urgent need for highly safe effective approach to address challenge HS with thick deep types. Inspired by superior tissue penetrative ability near-infrared-II (NIR-II) light potential mitochondria ROS inducing effect Chinese medicine lycorine (LYC), we fabricated Cu
Doxorubicin (DOX) leads to myocardial cell damage and irreversible heart failure, which limits the clinical application of DOX. Naringin has biological functions inhibiting inflammation, oxidative stress apoptosis. Our aim was investigate whether could prevent DOX-related cardiotoxicity in mice. administered by gavage mice were intraperitoneally injected with doxorubicin (1 mg/kg/day) for 15 days. H&E, Masson, TUNEL others experiments examined. NRVMs H9C2 cells treated DOX vitro. Using IF,...
<title>Abstract</title> <bold>Background:</bold>The purpose of this experiment was to investigate the effect PMA protocol (pericapsular nerve group (PENG), oxycodone and parecoxib) postoperative pain in direct anterior approach total hip arthroplasty (DAA-THA) patients with consistent preoperative thresholds .<bold>Objectives:</bold>To explore effective preemptive multimodal analgesic protocols meet needs enhanced recovery after surgery (ERAS) joint surgery.<bold>Study Design:</bold>This...
Open wounds face severe bacterial infection, which affects the quality of healing. Photothermal antimicrobial therapy has received increasing attention as a broad-spectrum treatment that can avoid drug resistance. A variety metallic materials have been used in development photothermal agents. However, there are few studies on bismuth agent and its use tissue repair, so is still lack clear understanding biomedical function. Here, hollow nanosphere prepared from metal was developed for loading...
Background: Hypertrophic scar (HS) is a fibrotic cutaneous disease with few effective therapies. Lycorine drug pro-apoptotic ability and anti-fibrosis potential. This study aimed to test whether lycorine could trigger the apoptosis of hypertrophic fibroblasts (HSFs) inhibit HS formation. Methods: The proapoptotic effects on viability human primary HSFs their reactive oxygen species (ROS) production as well rabbit ear model were determined by CCK-8, flow cytometry, Western blot,...
Background: Immunotherapy with checkpoint inhibitors usually has a low response rate in some cutaneous melanoma (CM) cases due to its cold nature. Hence, identification of hot tumors is important improve the immunotherapeutic efficacy and prognoses CMs. Methods: Fatty acid (FA) metabolism-related genes were extracted from Gene Set Enrichment Analysis used non-negative matrix factorization (NMF), copy number variation frequency, tumor mutation burden (TMB), immune-related analyses, such as...
Microbiota dysbiosis has been reported to lead leaky epithelia and trigger numerous dermatological conditions. However, potential causal associations between skin microbiota fibrosis whether immune cells act as mediators remain unclear.
Owing to the low ratio of patients benefitting from immunotherapy, patient stratification becomes necessary. An accurate contributes therapy for different tumor types. Therefore, this study aimed subdivide colon cancer improved combination immunotherapy.We characterized based on urea cycle metabolism, performed a consensus clustering analysis and constructed risk model in genome atlas cohort. Colon were further categorized into two tags: clusters, groups, exploration immunotherapy. In...