A5079023944- Animal Genetics and Reproduction
- Muscle Physiology and Disorders
- RNA Research and Splicing
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Advanced MRI Techniques and Applications
- Social Capital and Networks
- International Labor and Employment Law
- Advanced Neuroimaging Techniques and Applications
- China's Socioeconomic Reforms and Governance
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Dietary Effects on Health
- Cardiac Structural Anomalies and Repair
- Geology and Paleoclimatology Research
- Culture, Economy, and Development Studies
- Cerebral Palsy and Movement Disorders
- Probiotics and Fermented Foods
Vanderbilt University
2024
University of Rochester
2023-2024
Chongqing Medical University
2023
Beijing Anding Hospital
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chinese University of Hong Kong
2023
Nanjing University
2023
Nankai University
2022-2023
Capital University
2023
Capital Medical University
2023
In the face of poor prognosis and immunotherapy failure gastric cancer (GC), this project tried to find new potential biomarkers for predicting precision medication ameliorate situation. To form synthetic matrices, we retrieved stomach adenocarcinoma transcriptome data from Genotype-Tissue Expression Project (GTEx) The Cancer Genome Atlas (TCGA). Necroptosis-related prognostic lncRNA was identified by coexpression analysis univariate Cox regression. Then performed least absolute shrinkage...
Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles many lncRNAs in tumor progression remain unclear. In this study, we found that expression lncRNA TP53TG1 was downregulated gastric cancer (GC) and it functioned as a suppressor. addition, low significantly poor survival patients GC. inhibited proliferation, metastasis, cell cycle GC cells, while promoted their apoptosis. m6A modification sites highly abundant on TP53TG1, demethylase ALKBH5...
Disturbed gut microbiota is a potential factor in the pathogenesis of major depressive disorder (MDD), yet whether dysbiosis associated with severity MDD remains unclear. Here, we performed shotgun metagenomic profiling cross-sectional stool samples from (n = 138) and healthy controls 155). The patients were divided into three groups according to Hamilton Depression Rating Scale 17 (HAMD-17), including mild 24), moderate 72) severe 42) individuals, respectively. We found that microbial...
Pig is an important agricultural animal for meat production and provides a valuable model many human diseases. Functional studies have demonstrated that microRNAs (miRNAs) play critical roles in almost all aspects of skeletal muscle development disease pathogenesis. To investigate the miRNAs involved regulating different periods development, we herein performed comprehensive research porcine microRNAome (miRNAome) during 10 developmental stages including 35, 49, 63, 77, 91 dpc (days post...
Although the mechanism underlying modulation of transcription factors in myogenesis has been well elucidated, function cofactors involved this process remains poorly understood. Here, we identified HMGB2 as an essential nuclear transcriptional co-regulator myogenesis. was highly expressed undifferentiated myoblasts and regenerating muscle. Knockdown inhibited myoblast proliferation stimulated its differentiation. depletion downregulated Myf5 cyclin A2 at protein but not mRNA level. In...
Abstract Differentiation of myoblasts is essential in the development and regeneration skeletal muscles to form multinucleated, contractile muscle fibers. However, process myoblast differentiation mammals complicated requires be further investigated. In this study, we found Palmdelphin (Palmd), a cytosolic protein, promotes differentiation. Palmd predominantly expressed cytosol gradually up-regulated after Knockdown by small interfering RNA (siRNA) C2C12 markedly inhibits myogenic...
Long noncoding RNAs (lncRNAs) have been reported to regulate diverse tumorigenic processes. However, little is known about long intergenic non-protein coding RNA 00893 (LINC00893) and its role in gastric cancer (GC). Herein we investigated biological functions molecular mechanism GC. LINC00893 was decreased GC tissues but significantly elevated AGS cells after treatment with Nutlin-3. In patients, it found that low expression of correlated tumor growth, metastasis poor survival....
The investigation of skeletal muscle development is importance in stock farming and biomedicine. It still ambiguous that whether animals are born with the full set fibers or if number myofibers continues to increase postnatally. Here, an inducible lineage-tracing system was employed monitor changes myofiber various muscles during development. We confirm total longissimus dorsi, gastrocnemius rectus femoris determined prenatally. However, tibialis anterior extensor digitorum longus have a...
Pig (Sus scrofa) is a major source of dietary proteins for human consumption and becoming valuable model in agricultural biomedical research. The recently developed isobaric tag relative absolute quantitation (iTRAQ) method allows sensitive accurate protein quantification. Here, we performed the first iTRAQ-based quantitative proteomic analyses Landrace (LR) Wuzhishan (WZS) pig longissimus dorsi muscle tissues during early embryonic development. study LR WZS ranging from 21 to 42 days post...
Methylated syndecan2 (mSDC2) in stool samples has been found to be associated with colorectal cancer (CRC) and precancerous lesions. However, the available data are limited, no previous studies have compared analysis of mSDC2 other diagnostic tests. Thus, we aimed evaluate clinical performance a test compare its that blood-based tests for methylated septin9 (mSEPT9), carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) 724 (CA724) detecting neoplasms.The gold standard technique was...
CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to Rho family.The family plays an important role in variety cellular processes including skeletal myogenesis.Here, we find expression increased significantly during C2C12 myogenesis.Overexpression could attenuate myoblast differentiation, while knockdown by siRNA results enhancing myogenesis.Furthermore, demonstrate for first time attenuates differentiation via suppression muscle regulatory factors (MRFs) rather than influencing...
Myofibroblast transdifferentiation is an important feature of cardiac fibrosis. Previous studies have indicated that microRNA‑216a (miR‑216a) upregulated in response to transforming growth factor‑β (TGF‑β) kidney cells and can activate Smad3; however, its role myofibroblast remains unclear. The present study aimed investigate the miR‑216a TGF‑β‑induced transdifferentiation, determine underlying mechanisms. Adult mouse fibroblasts were treated with TGF‑β induce transdifferentiation. An...
INTRODUCTION: To define the prognosis of colorectal cancer (CRC) in young patients and to compare their postoperative treatment with that older patients. METHODS: This multicenter study enrolled 5,457 primary CRC who underwent surgical resection. The overall survival (OS), clinicopathologic characteristics, 253 aged 18–44 years 5,204 44–80 were analyzed. RESULTS: OS rate was 77.1% for 74.2% ( P = 0.348). Landmark analysis showed a significant difference between patients, 63.8% deaths among...
BACKGROUND We aimed to evaluate the ability of circulating cell-free methylated SETP9 DNA (mSEPT9) identify recurrence and determine its clinical utility in adjuvant chemotherapy (ACT) regimen decisions. MATERIAL AND METHODS This study enrolled 426 patients with stage II-III CRC who received radical resection between January 8, 2018, November 30, 2020. The median follow-up duration was 15.8 months (range, 8.1-43.4 months). primary endpoint recurrence-free survival (RFS). A propensity score...
Resourceful disposal of landfill leachate has always been an intractable worldwide problem. This study was conducted to investigate the feasibility biologically treating a combined waste stream and high-concentration nitrate nitrogen (high-nitrate) wastewater. Raw pretreated using anaerobic fermentation ammonia stripping improve biodegradability. The control sequencing batch reactor (SBR, named R0) fed only with synthetic high-nitrate wastewater sodium acetate as carbon source, whereas other...
Abstract This paper discusses ways in which negative economic shocks captured by natural disasters can shape internal labor migration China. The impact of on depends the combination two opposite driving forces: (i) make staying affected area less profitable, thus enhancing returns to migration; (ii) it more difficult migrate out, inducing a higher fixed cost migration. Based nationwide dataset China, this shows that when were not severe, they caused out rural areas. With sufficiently severe...
The internal arrangement of a muscle's fibers with respect to its mechanical line action (muscle architecture) is major determinant muscle function. Muscle architecture can be quantified using diffusion tensor magnetic resonance imaging-based tractography, which propagates streamlines from set seed points by integrating vectors that represent the direction greatest water (and inference, local fiber orientation). Previous work has demonstrated tractography outcomes are sensitive method for...