A5102022380- Colorectal Cancer Screening and Detection
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Diverticular Disease and Complications
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Sirtuins and Resveratrol in Medicine
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Cancer-related gene regulation
- Chemokine receptors and signaling
- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Advanced Cellulose Research Studies
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
Nankai University
2013-2024
Tianjin People's Hospital
2014-2024
Tianjin University of Science and Technology
2023-2024
Xiangya Hospital Central South University
2016
Central South University
2016
Union Hospital
2014
Colorectal cancer exhibits a notable prevalence and propensity for metastasis, but the current therapeutic interventions metastatic colorectal have yielded suboptimal results. ICIs can decrease tumor development by preventing tumor's immune evasion, presenting patients with new treatment alternative. The increased use of checkpoint inhibitors (ICIs) in CRC has brought several issues. In particular, demonstrated significant clinical effectiveness MSI-H CRC, whereas their efficacy is limited...
Abstract Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named lnc-C/EBPβ MDSCs, which control suppressive functions MDSCs. Lnc-C/EBPβ could induced vitro vivo tumor inflammatory environments. It set target transcripts, Arg-1, NOS2, NOX2, COX2, to...
Colorectal cancer (CRC) represents one of the most common malignancies with high morbidity worldwide. RNA methylation (m6A) has been considered to tremendously contribute initiation and progression since its first discovery. In this study, we comprehensively analyzed associations between mRNA expressions m6A regulators CRC tumor samples' epidemiologic information from Cancer Genome Atlas (TCGA). Multivariate Cox proportional hazard model was applied screening whose were significantly...
Purpose:We previously reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride (CoCl2) exhibit stem cell properties.Daughter generated PGCCs possess epithelial mesenchymal transition (EMT) phenotype changes and EMT plays an important role in development progression.This study investigated the characteristics of from LoVo HCT116 CoCl2 clinicopathological significances colorectal (CRC).Materials Methods: Western blotting immunocytochemical staining were used to compare...
The aim of the present study was to screen colorectal cancer (CRC) tissue and adjacent for differences in circular RNA (circRNA) expression, analyze related miRNAs messenger RNAs (mRNAs), investigate circRNA expression CRC its function. profile generated using CapitalBio microarray technology. differentially expressed circRNAs were identified with GeneSpring 12.5 software. Subsequently, mRNAs annotated molecule annotation system (MAS) 3.0, diseases, pathways functional enrichment analysis...
Radiation enteritis (RE) is the most common radiotherapy complication, and effective RE treatments are lacking. Resveratrol exerts beneficial effects on radiation injury. However, effect of resveratrol in radiation-induced intestinal injury underlying mechanism remain unclear. Here, a C57BL/6 mouse model was established an epithelial cell line used to evaluate protective against mechanisms. improved oxidative stress apoptosis via upregulating antioxidant enzymes downregulating p53...
Purpose: Tientsin Albino 2 (TA2) mice have a high incidence of spontaneous breast cancer. Tumor initiation is related to mouse mammary tumor virus (MMTV) infection. MMTV hormonally regulated and may promote formation via Wnt/β-catenin signaling pathway. This study attempts clarify the relationship between β-catenin expression metastasis cancer in TA2 mice. Materials Methods: Pathological samples illustrating development were collected presence particles was verified tissue by electron...
Intrinsic autophagy is important for the maintenance of intestinal homeostasis and regeneration. Ionizing radiation suppresses intrinsic reduces damage-induced regeneration in intestine, resulting injury. Resveratrol, a sirtuin 1 (SIRT1) agonist, promotes exerts radioprotective effect. In this study, protective effect resveratrol against radiation-induced injury its potential mechanism were investigated. Intestinal epithelial cells (IEC-6) exposed to 10 Gy ionizing (0.1-40.0 μM). Cell...
Myeloid-derived suppressor cells (MDSCs), which play an important role in tumor and inflammatory diseases, are divided into two subsets CD11b+Ly6ChiLy6G– monocytic MDSC (Mo-MDSC) CD11b+Ly6Clow/negLy6G+ polymorphonuclear (PMN-MDSC) with different immunosuppressive function. However, it is poorly understood the mechanism(s) to control differentiation of Mo-MDSCs PMN-MDSCs. Here, we found that lnc-C/EBPβ may impede generation Mo-MDSCs, but promote PMN-MDSC vitro vivo. We demonstrated mediated...
The recent uptrend in colorectal cancer (CRC) incidence China is causing an increasingly overwhelming social burden. And its occurrence can be effectively reduced by sensitizing CRC screening for early diagnosis and treatment. However, a large number of people do not undergo due to multiple factors. To address this issue, since 2012, program has been initiated Tianjin.Residents aged 40-74 years were eligible screening. first was complete the high-risk factor questionnaire (HRFQ) fecal...
Abstract Aim Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to anatomical site. We explored risk factors for four groups neoplasms (CRN) at different sites. Methods extracted data from database Tianjin Colorectal Cancer Screening Program 2010 2020. According CRN sites, patients were divided into groups: proximal colon group, distal rectum multiple Binary logistic regression analysis was used explore differences in Results The numbers...
Our previous study has suggested that downregulated microRNA (miR)-29a in denatured dermis might be involved burn wound healing. However, the exact role of miR-29a healing injury still remains unclear. Here, we found expression was notably upregulated tissues and skin fibroblast cells after thermal injury, thereafter gradually compared with control group. By contrast, collagen, type I, alpha 2 (COL1A2) vascular endothelial growth factor (VEGF-A) were first reduced subsequently injury. We...
Background This study aimed to develop an artificial intelligence predictive model for predicting the probability of developing BM in CRC patients. Methods From SEER database, 50,566 patients were identified between January 2015 and December 2019 without missing data. SVM LR models trained tested on dataset. Accuracy, area under curve (AUC), IDI used evaluate compare models. Results For bone metastases entire cohort, with poly as kernel function presents best performance, whose accuracy is...
Methylated syndecan2 (mSDC2) in stool samples has been found to be associated with colorectal cancer (CRC) and precancerous lesions. However, the available data are limited, no previous studies have compared analysis of mSDC2 other diagnostic tests. Thus, we aimed evaluate clinical performance a test compare its that blood-based tests for methylated septin9 (mSEPT9), carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) 724 (CA724) detecting neoplasms.The gold standard technique was...
The aim of the present study was to investigate mechanism metastasis in colorectal cancer (CRC) using microRNA (miRNA) and mRNA expression profiles. miRNA profiles GSE2509 GSE56350 datasets were obtained from Gene Expression Omnibus database. differentially expressed genes (DEGs) miRNAs (DEMs) identified limma software package. Database for Annotation, Visualization Integrated Discovery used perform Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis DEGs....
BACKGROUND The aim of this study was to screen the molecular targets miR-34a in colorectal cancer (CRC) and construct regulatory network, gain more insights pathogenesis CRC. MATERIAL AND METHODS microarray data CRC samples normal (GSE4988), as well transformed with non-transfected (GSE7754), were downloaded from Gene Expression Omnibus (GEO) database. differently expressed genes (DEGs) identified via LIMMA package R language. Database for Annotation, Visualization Integrated Discovery...
Radiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance crucial cause poor therapeutic outcomes in cancer. However, underlying mechanism radioresistance still poorly defined. Herein we established a radioresistant cell line and performed transcriptomics analyses to search genes that contribute investigate its association prognosis CRC patients.The was developed from parental HCT116 by stepwise increased dose irradiation....
Abstract Background Screening recommendations for colorectal cancer (CRC) are mainly based on family history rather than lifestyle risk factors. We aimed to assess and compare factors neoplasm (CRN) evaluate trends in detection rates during the three rounds of screening from 2012 2020 Tianjin, China. Methods This study was 89,535 first-recorded colonoscopies Tianjin CRC program, 2012–2020. Of these, 45,380 individuals with complete were included population attributable fraction (PAF)...
Abstract Purpose Colorectal cancer (CRC) screening has been implemented in Tianjin, China since 2012. The objective was to estimate the neoplasia detection rate a high-risk population by age and sex investigate potential factors associated with colorectal neoplasia. Patients methods This study is based on data of Tianjin CRC program from 2012 2020. Residents positive questionnaire (HRFQ) or faecal immunochemical test (FIT) were identified as participants subsequently recommended for free...