A5061948898- Immune cells in cancer
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
Guiyang University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Nankai University
2017-2019
Long noncoding RNA (lncRNA) plays a critical role in many biological processes, such as cell differentiation and development. However, few studies about lncRNAs regulating the development of myeloid-derived suppressor cells (MDSCs) exist. In this study, we identified lncRNA pseudogene, Olfr29-ps1, which was expressed MDSCs upregulated by proinflammatory cytokine IL6. The Olfr29-ps1 vertebrates is conserved, similarity between human OR1F2P sequence 43%. This promoted immunosuppressive...
Abstract Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named lnc-C/EBPβ MDSCs, which control suppressive functions MDSCs. Lnc-C/EBPβ could induced vitro vivo tumor inflammatory environments. It set target transcripts, Arg-1, NOS2, NOX2, COX2, to...
Myeloid-derived suppressor cells (MDSCs) play a critical role in regulating immune responses cancer and other pathological conditions. Mechanism(s) MDSC differentiation function is not completely clear, especially epigenetic regulation. In this study, we found that MDSCs express retinal non-coding RNA3 (RNCR3), the expression upregulated by inflammatory tumor associated factors. RNCR3 may as competing endogenous RNA (ceRNA) to promote Chop sponging miR-185-5p during differentiation....
Myeloid-derived suppressor cells (MDSCs), which play an important role in tumor and inflammatory diseases, are divided into two subsets CD11b+Ly6ChiLy6G– monocytic MDSC (Mo-MDSC) CD11b+Ly6Clow/negLy6G+ polymorphonuclear (PMN-MDSC) with different immunosuppressive function. However, it is poorly understood the mechanism(s) to control differentiation of Mo-MDSCs PMN-MDSCs. Here, we found that lnc-C/EBPβ may impede generation Mo-MDSCs, but promote PMN-MDSC vitro vivo. We demonstrated mediated...
Gut microbiota may not only affect composition of local immune cells but also systemic cells. However, it is completely clear how gut modulate these systems. We here found that there have expanded macrophage pools in huREG3γ tgIEC mice. REG3γ associated Lactobacillus, which homology to Lactobacillus Taiwanese, could enlarge the small intestinal lamina propria spleen and adipose tissues. STAT3 mediated signal(s) was a critical factor anti-inflammatory macrophages. offered evidence for...
Food-derived collagen peptides have recently been reported to immunomodulatory functions. The Chinese giant salamander (CGS) has both edible and medicinal values. In this study, we tried verify the immunoregulatory function of CGS skin (CGSSCPs) on macrophages elucidate its mechanism. CGSSCPs decreased secretion nitric oxide (NO) downregulated expression interleukin-6 (IL-6), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), chemokine (C–C motif) ligand 5 (CCL5) (C-X-C 10 (CXCL10) in...
<p>Reagents and primers</p>
<p>Supplementary Materials and methods</p>
<p>Figure S1. Characterization of inflammatory cytokine and tumor mediated MDSCs. Figure S2. Characteristics lnc-C/EBPβ. S3. Sequences mouse lnc-C/EBPβ humanlnc-C/EBPβ. S4. The suppressive MDSC isolated from tumors may express high levels both Lnc-C/EBPβ C/EBPβ. S5. associated factors Lnc-C/EBP� are dependent on STAT3. S6. Gene microarray shRNA/letiviruses lnc-C/EBPβ/lentiviruses transduced cells. S7. impedes differentiation M-MDSCs. S8. also impacts survival S9. binding to...
<div>Abstract<p>Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named <i>lnc-C/EBPβ</i> MDSCs, which control suppressive functions MDSCs. <i>Lnc-C/EBPβ</i> could induced <i>in vitro</i> vivo</i> tumor...
<p>Reagents and primers</p>
<p>Figure S1. Characterization of inflammatory cytokine and tumor mediated MDSCs. Figure S2. Characteristics lnc-C/EBPβ. S3. Sequences mouse lnc-C/EBPβ humanlnc-C/EBPβ. S4. The suppressive MDSC isolated from tumors may express high levels both Lnc-C/EBPβ C/EBPβ. S5. associated factors Lnc-C/EBP� are dependent on STAT3. S6. Gene microarray shRNA/letiviruses lnc-C/EBPβ/lentiviruses transduced cells. S7. impedes differentiation M-MDSCs. S8. also impacts survival S9. binding to...
<p>Supplementary Materials and methods</p>
<div>Abstract<p>Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named <i>lnc-C/EBPβ</i> MDSCs, which control suppressive functions MDSCs. <i>Lnc-C/EBPβ</i> could induced <i>in vitro</i> vivo</i> tumor...