A5100368695- Immune cells in cancer
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Cardiac Fibrosis and Remodeling
- Endometrial and Cervical Cancer Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Ferroptosis and cancer prognosis
- Reproductive System and Pregnancy
- Signaling Pathways in Disease
- Colorectal and Anal Carcinomas
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Cardiovascular Function and Risk Factors
- Temporomandibular Joint Disorders
- Adipokines, Inflammation, and Metabolic Diseases
Air Force Medical University
2015-2024
Chongqing Public Health Medical Center
2024
Chongqing Medical University
2024
South China University of Technology
2022-2024
Wenzhou Medical University
2024
Northwestern Polytechnical University
2021-2023
Sun Yat-sen University
2022-2023
Third Affiliated Hospital of Sun Yat-sen University
2023
University of Electronic Science and Technology of China
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Abstract Myeloid-derived suppressor cells (MDSCs) were one of the major components immune suppressive network. STAT3 has an important role in regulating potential MDSCs. In this study, we found that expression could be modulated by both miR-17-5p and miR-20a. The transfection or miR-20a remarkably reduces reactive oxygen species production H2O2, which are regulated STAT3. MDSCs transfected with less able to suppress Ag-specific CD4 CD8 T cells. Importantly, alleviate function vivo....
The pathological changes of subchondral bone during osteoarthritis (OA) development in the temporomandibular joint (TMJ) are poorly understood. In present study, we investigated longitudinal alterations using a rat TMJ-OA model developed our laboratory. Changes mass were examined by micro-CT, and osteoblast osteoclast activities analyzed real-time PCR, immunohistochemistry, TRAP staining. Subchondral loss was detected from 8 weeks after dental occlusion alteration reached maximum at 12...
Abstract Tumor‐associated factors are related to increased accumulation of CD11b + Gr1 myeloid‐derived suppressor cells (MDSCs). However, the exact mechanism how genetic control expansion MDSCs in tumor‐bearing hosts remains elusive. Herein, we found that tumor‐associated and their subsets, mononuclear polymorphonuclear MDSCs, have decreased expression miR‐223 when compared from spleen disease‐free mice. With differentiation bone marrow (BMCs) upon exposure factors, both pri‐miR‐223 mature...
Myeloid-derived suppressor cells (MDSCs) are major regulators of immune responses in cancer. Both C/EBP homologous protein (CHOP) and C/EBPβ play a critical role regulating immunosuppressive function MDSCs. In this study, we identified novel long noncoding RNA termed as lnc-chop MDSCs, which may interact with CHOP the isoform liver-enriched inhibitory protein. The binding both promoted activation upregulated expression arginase-1, NO synthase 2, NADPH oxidase cyclooxygenase-2, related to...
Abstract Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named lnc-C/EBPβ MDSCs, which control suppressive functions MDSCs. Lnc-C/EBPβ could induced vitro vivo tumor inflammatory environments. It set target transcripts, Arg-1, NOS2, NOX2, COX2, to...
Berberine, a small molecule derived from Coptidis rhizome, has been found to be potent at lowering blood glucose and regulating lipid metabolism. Recent clinical studies have shown that berberine reduces pressure increases systemic insulin sensitivity in patients with metabolic syndrome; however, the underlying mechanism is still unclear. Here, we investigated by which improves vascular diabetic rats.Diabetes was induced male Sprague–Dawley rats feeding high-fat diet administration of low...
Abstract A close link between heart failure (HF) and systemic insulin resistance has been well documented, whereas myocardial its association with HF are inadequately investigated. This study aims to determine the role of in ischemic underlying mechanisms. Male Sprague-Dawley rats subjected infarction (MI) developed progressive left ventricular dilation dysfunction at 4 wk post-MI. Of note, sensitivity was decreased as early 1 after MI, which accompanied by increased production TNF-α....
Abstract The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in play crucial roles metastasis process. Shifting tumor-promoting M2-like TAMs toward M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and secretion inhibitory factors, may be a potential therapeutic strategy cancer treatment. We first cloned NDRG2 (N-myc downstream-regulated gene 2) verified its role multiple solid tumors, including...
Myeloid-derived suppressor cells (MDSCs) constitute one of the major populations that potently suppress anti-tumor immune responses and favor tumor growth in microenvironment. However, mechanism(s) regulating differentiation suppressive function tumor-associated MDSCs remain(s) unclear. Here, we identified a microRNA-200c (miR-200c), whose expression was dramatically induced by tumor-derived factors. Meanwhile, also demonstrated GM-CSF main inducer miR-200c environment, turn promoted...
Tumor-induced immunosuppressive microenvironment in which myeloid-derived suppressor cells (MDSCs) plays an important role, remains obstacle for effective oncotherapy currently. Inducing MDSCs into maturation was confirmed as method to reduce the tumor-bearing host's immunosuppression. Traditional Chinese medicines (TCM) possess characteristics of alleviating immunosuppression cancer patients and low toxicity. Jianpi Huayu Decoction (JHD) experienced formula TCM based on theory clinical...
Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies the effects co-stimulatory molecule CD226 on Treg are controversial. Here, we show that primarily maintains cell stability metabolism phenotype under inflammatory conditions. Conditional deletion within Foxp3+ exacerbates symptoms in murine graft versus host disease models. cell-specific increases percentage immune organs but weakens their...
The expression and function of ribosomal s6 protein kinase 4 (RSK4) in renal cell carcinoma (RCC) are unknown. Immunohistochemistry was used to detect the RSK4 RCC, relationship between clinicopathological features as well prognosis RCC patients statistically analysed. Ectopic lines performed determine its effect on cycle regulation, tumour invasiveness, metastatic capability. overexpressed RCCs (P=0.003), compared with normal tissues, varied different subtypes (P=0.021), especially two...
Myeloid-derived suppressor cells (MDSCs), which play an important role in tumor and inflammatory diseases, are divided into two subsets CD11b+Ly6ChiLy6G– monocytic MDSC (Mo-MDSC) CD11b+Ly6Clow/negLy6G+ polymorphonuclear (PMN-MDSC) with different immunosuppressive function. However, it is poorly understood the mechanism(s) to control differentiation of Mo-MDSCs PMN-MDSCs. Here, we found that lnc-C/EBPβ may impede generation Mo-MDSCs, but promote PMN-MDSC vitro vivo. We demonstrated mediated...
Objectives: To investigate the expression of 78‐kDa glucose‐regulated protein (GRP78), a marker activation unfolded response (UPR), in macrophages ankylosing spondylitis (AS) synovium and synovial fluid to explore relationship between GRP78 levels proinflammatory cytokines, as well inflammatory activity AS.
STAT3 plays a critical role in myeloid-derived suppressor cell (MDSC) accumulation and activation. Most studies have probed underlying mechanisms of However, epigenetic events involved activation are poorly understood. In this study, we identified several epigenetic-associated proteins such as p66a (Gatad2a), novel protein transcriptional repressor that might interact with functional MDSCs, by using immunoprecipitation mass spectrometry. could regulate the phosphorylation ubiquitination...