A5027459053- Immune cells in cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Developmental Biology and Gene Regulation
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Macrophage Migration Inhibitory Factor
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Influenza Virus Research Studies
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Mechanisms of cancer metastasis
- Respiratory Support and Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
Air Force Medical University
2015-2024
Tang Du Hospital
2014-2024
The Second Nanning People's Hospital
2024
First Affiliated Hospital of GuangXi Medical University
2020-2023
Guangxi Medical University
2020-2023
Affiliated Hospital of Jiangsu University
2022
Jiangsu University
2022
Beijing Children’s Hospital
2021
Capital Medical University
2021
Xi'an Medical University
2020
Macrophages are important tumor-infiltrating cells and play pivotal roles in tumor growth metastasis. participate immune responses to tumors a polarized manner: classic M1 macrophages produce interleukin (IL) 12 promote tumoricidal responses, whereas M2 IL10 help progression. The mechanisms governing macrophage polarization unclear. Here, we show that the M2-like tumor-associated (TAM) have lower level of Notch pathway activation mouse models. Forced signaling increased which IL12, no matter...
Abstract Tumor-associated macrophages (TAMs) are a major component of tumor microenvironment (TME) and play pivotal roles in the progression hepatocellular carcinoma (HCC). Wnt signaling is evolutionarily conserved participates liver tumorigenesis. Several studies have shown that macrophage-derived ligands can activate cells. However, whether secreted by cells trigger still elusive. In this study, we first verified canonical Wnt/β-catenin was activated during monocyte-to-macrophage...
The Notch pathway plays critical roles in the differentiation and polarized activation of macrophages; however, downstream molecular mechanisms underlying activity macrophages remain elusive. Our previous study has identified a group microRNAs that mediate signaling to regulate macrophage tumor-associated (TAMs). In this study, we demonstrated miR-148a-3p functions as novel molecule promote monocytes into presence granulocyte colony-stimulating factor (GM-CSF). Meanwhile, promoted M1...
Abstract Tumor-associated macrophages (TAM) contribute greatly to hallmarks of cancer. Notch blockade was shown arrest TAM differentiation, but the precise role and underlying mechanisms require elucidation. In this study, we employed a transgenic mouse model in which Notch1 intracellular domain (NIC) is activated conditionally define effects active signaling macrophages. NIC overexpression had no effect on it abrogated function, leading repressed growth transplanted tumors. Macrophage miRNA...
Abstract Tumor-associated macrophages (TAM) play pivotal roles in tumor progression and metastasis, but the contribution regulation of different macrophage populations remain unclear. Here we show that Notch signaling plays distinct regulating TAM subsets hepatocellular carcinoma (HCC). Myeloid-specific NOTCH blockade by conditional disruption recombination signal binding protein Jκ (RBPj cKO) significantly delayed growth subcutaneously inoculated Lewis lung (LLC), accelerated orthotopically...
The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that activation promotes M1 polarization phagocytosis macrophages; however, downstream molecular mechanisms mediating signal remain elusive. In an attempt to identify targets bone marrow-derived macrophages (BMDMs) using mass spectrometry, regulatory protein α (SIRPα) appeared respond knockout recombination signal-binding Jk (RBP-J), transcription factor...
Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) play critical roles in tumorigenesis. However, the mechanisms underlying MDSC TAM development function remain unclear. In this study, we find that myeloid-specific activation of Notch/RBP-J signaling downregulates lactate transporter MCT2 transcription via its downstream molecule Hes1, leading to reduced intracellular levels, blunted granulocytic (G-MDSC) differentiation, enhanced maturation. We identify c-Jun...
Hepatic ischemia/reperfusion (I/R) injury is initiated by reactive oxygen species (ROS) accumulated during the early reperfusion phase after ischemia, but cellular mechanisms controlling ROS production and scavenging have not been fully understood. In this study, we show that blocking Notch signal knockout of transcription factor RBP-J or a pharmacological inhibitor led to aggravated hepatic I/R injury, as manifested deteriorated liver function increased apoptosis, necrosis, inflammation,...
Background Accumulating evidence has shown that tumor-associated macrophages (TAMs) play a critical role in tumor progression. Targeting TAMs is potential strategy for immunotherapy. However, the mechanism underlying TAM phenotype and function needs to be resolved. Our previous studies have demonstrated miR-125a can reverse toward antitumor. Meanwhile, we found miR-99b cluster first intron of same host gene, are transcribed simultaneously bone marrow-derived (BMDMs) following LPS+IFNγ...
Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4+ T cells had expressed (exAID cells) as well B cells. ExAID increased with age, reaching up to 25% of and B220+ cell populations. remained IgM+, suggesting class-switched memory do not accumulate in spleen. In cells, AID was subset IFN-γ IL-10 but little IL-4 or IL-17, showed no...
Macrophages play multidimensional roles in hepatic fibrosis, but their control has not been fully understood. The Notch pathway mediated by recombination signal binding protein Jκ (RBP‐J), the transcription factor transactivated signals from four mammalian receptors, is implicated macrophage activation and plasticity. In this study, using mouse fibrosis models, we show that myeloid‐specific disruption of RBP‐J resulted attenuated fibrosis. stellate cells production profibrotic factors...
Abstract The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in play crucial roles metastasis process. Shifting tumor-promoting M2-like TAMs toward M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and secretion inhibitory factors, may be a potential therapeutic strategy cancer treatment. We first cloned NDRG2 (N-myc downstream-regulated gene 2) verified its role multiple solid tumors, including...
BackgroundParacellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor inhibit colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation colitis-associated is unclear.MethodsIntestine-specific Ndrg2 deficiency mice (Ndrg2ΔIEC) were subjected DSS- or TNBS-induced colitis, AOM-DSS-induced tumour. HT29 cells, Caco2...
CD169, a specific marker for macrophages, is member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family which acts as an adhesion molecule implicated in cell–cell interaction via sialylated glycoconjugates. Although CD169+ macrophages have been found to participate erythroblastic island (EBI) formation and support erythropoiesis under homeostasis stress, exact role CD169 its counter receptor EBI remains unknown. Herein, we generated CD169-CreERT knock-in mice investigated...
The primary objective of this study was to explore the clinical characteristics apoplectic intratumoral hemorrhage in gliomas and offer insights for improving diagnosis treatment disease.