A5084908926- Osteoarthritis Treatment and Mechanisms
- Temporomandibular Joint Disorders
- Bone health and treatments
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Oropharyngeal Anatomy and Pathologies
- Genetics and Neurodevelopmental Disorders
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Neurogenesis and neuroplasticity mechanisms
- Hedgehog Signaling Pathway Studies
- Bone and Joint Diseases
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Bone Tumor Diagnosis and Treatments
- Uterine Myomas and Treatments
- Glass properties and applications
- Cancer Cells and Metastasis
- Advanced ceramic materials synthesis
- 3D Printing in Biomedical Research
- Corneal Surgery and Treatments
- Heterotopic Ossification and Related Conditions
- Ovarian cancer diagnosis and treatment
- Connective tissue disorders research
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Qilu Hospital of Shandong University
2025
Xi'an Jiaotong University
2025
Air Force Medical University
2006-2021
Xijing Hospital
2016-2017
Zero to Three
2014
Resistance to trastuzumab and concomitantly distal metastasis are leading causes of mortality in HER2‐positive breast cancers, the molecular basis which remains largely unknown. Here, we generated trastuzumab‐resistant cancer cells with increased tumorigenicity invasiveness compared parental cells, observed robust epithelial–mesenchymal transition (EMT) consistently elevated TGF‐β signaling these cells. MiR‐200c, was most significantly downregulated miRNA restored sensitivity suppressed...
The pathological changes of subchondral bone during osteoarthritis (OA) development in the temporomandibular joint (TMJ) are poorly understood. In present study, we investigated longitudinal alterations using a rat TMJ-OA model developed our laboratory. Changes mass were examined by micro-CT, and osteoblast osteoclast activities analyzed real-time PCR, immunohistochemistry, TRAP staining. Subchondral loss was detected from 8 weeks after dental occlusion alteration reached maximum at 12...
The present study aimed to investigate the therapeutic effect of injections local bone marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) temporomandibular joint (TMJ) and explore role stromal cell–derived factor 1 (SDF-1) regulated activation, normal T-cell expressed secreted (RANTES) in this effect. Fundamentally, OA TMJ was induced by unilateral anterior crossbite mice. Exogenous green fluorescent protein–labeled BMSCs (GFP-BMSCs) were weekly injected into region for 4, 8, 12...
Emerging evidence has implied that subchondral bone plays an important role during osteoarthritis (OA) pathology. This study was undertaken to investigate whether abnormalities of the condylar lead temporomandibular joint (TMJ) OA. We used osteoblast-specific mutant TGF-β1 transgenic mouse, CED in which high levels active occur marrow, leading abnormal remodeling. Subchondral changes mandibular condyles were investigated by micro-CT, and alterations TMJ confirmed histopathological...
Increased subchondral trabecular bone turnover due to imbalanced bone-resorbing and bone-forming activities is a hallmark of osteoarthritis (OA). Wnt5a/Ror2 signaling, which can derive from marrow stromal cells (BMSCs), takes role in modulating osteoblast osteoclast formation. We showed previously that experimentally unilateral anterior crossbites (UACs) elicited OA-like lesions mice temporomandibular joints (TMJs), displaying as loss. Herein, we tested the BMSC-derived signaling regulating...
Summary The effect of unilateral anterior crossbite on the remodelling mandibular condyle needs to be investigated. This study aimed investigate effects experimentally created and explore changes in expression relevant transcription factors growth factors. experimental was 6‐week‐old female growing rats by bonding metal tubes left pairs incisors. Remodelings condylar cartilage assessed histologically at 2, 4 8 weeks. Protein mRNA levels Sox9, runt‐related factor 2 (Runx2), Osterix (Osx),...
Summary Activated calcium‐/calmodulin‐dependent protein kinaseII (Ca MK II) is important to promote chondrocytes from proliferative pre‐hypertrophic state, which probably plays a role in osteoarthritis ( OA ), widespread degeneration disease with enhanced aberrant chondrocyte differentiation. Our aim was detect the of Ca II, and its relationship feedback loop Indian hedgehog (Ihh) Parathyroid‐related peptide (PTHrP) temporomandibular joints TMJ s) . KN 93, competitive inhibitor added culture...
Prostaglandin E 2 (PGE ) plays important roles in the bone resorption of inflammatory diseases such as rheumatoid arthritis and periodontitis via specific prostaglandin receptors ( i.e., EP1-EP4). In this study, authors examined whether Prevotella intermedia regulates PGE production EP expression human periodontal ligament fibroblasts (hPDLs); they also explored potential signaling pathways involved production. P. induced cyclooxygenase-2 (COX-2) a dose- time-dependent manner. Indomethacin...
To study the effect of B2O3 and P2O5 on fluorosilicic mica glass-ceramic sintering process, six sets K2O-MgO-SiO2-F glasses were prepared by using as aid, respectively. Green bodies glass powder formed gel casting sintered at 800, 850, 900, 950, 1000oC for 6 hours, resectively. The crystallization behavior studied thermal shrinkage , X-ray diffraction SEM. results showed that rate with 2wt% was highest, while 5wt% lowest. An additional crystal other than precipitated in ceramics generated...