A5017730875- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- Analytical Methods in Pharmaceuticals
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Crystallography and molecular interactions
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- DNA and Nucleic Acid Chemistry
- Cancer, Stress, Anesthesia, and Immune Response
- Blood Pressure and Hypertension Studies
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Cardiac Imaging and Diagnostics
- Air Quality and Health Impacts
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2019-2025
Sun Yat-sen University
1997-2025
Guangdong Ocean University
2024
Maternal and Child Health Hospital of Sichuan Province
2023
Tsinghua University
2023
South China University of Technology
2014-2022
Jinhua Central Hospital
2022
Dalian Maritime University
2022
Background: The triglyceride-glucose (TyG) index could serve as a convenient substitute of insulin resistance (IR), but epidemiological evidence on its relationship with the long-term risk mortality is limited. Methods: Participants from National Health and Nutrition Examination Survey during 1999–2014 were grouped according to TyG (<8, 8–9, 9–10, >10). Cox regression was conducted compute hazard ratios (HRs) 95% confidence interval (CI). Restricted cubic spline piecewise...
Hyperbolic metamaterials (HMMs) have recently attracted significant research attention due to their hyperbolic wavevector iso-frequency contour, which leads substantial local electric field (EF) enhancements that benefit optical processes, such as the nonlinear generation, quantum science, biomedical sensing, and more. However, three main challenges hinder practical implementation: difficulty in exciting resonant modes using free-space incidence, weak enhancement of surface EF, narrow...
Background: The expression profiles and function of exosomal long RNAs (exoLRs) in ischemic stroke remain unknown. This study aimed to investigate the pathophysiologic responses reflected by exoLRs. Methods: profile messenger RNA, non-coding RNA circular 9 patients with 12 healthy individuals were analyzed sequencing. We assessed immune cell landscape reveal exoLRs performed biological process pathway enrichment analyses. Competing endogenous networks constructed explore molecular functions...
Abstract GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human remain unidentified. expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic β‐cell dysfunction, decreasing insulin production, resistance, and obesity. Animal studies suggested that potential therapeutic target T2DM treatment. underlying mechanisms leading self‐activation unknown. In our co‐expression analysis, we noted...
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes CAD and their potential causal effects impacts left ventricular remodeling remains limited. We aim to assess contribution plasma metabolites risk death major adverse cardiovascular events (MACE) as well remodeling. Results In prospective study with 1606 Chinese patients CAD, we have identified validated several independent through...
Genetic variants in the pharmacokinetic (PK) mechanism are main underlying factors affecting antiplatelet response to clopidogrel. Using a genomewide association study (GWAS) identify new genetic loci that modify effects Chinese patients with coronary heart disease, we identified novel two transporter genes ( SLC14A2 rs12456693, ATP‐binding cassette [ ABC ] A1 rs2487032) and N6AMT1 (rs2254638) associated P2Y12 reaction unit (PRU) plasma active metabolite (H4) concentration. These...
Abstract Background The link between total cholesterol (TC) and all-cause specific mortality has not been elucidated. Herein, we aimed to evaluate the effect of TC levels on all-cause, cardiovascular disease (CVD), cancer mortality. Methods All data analyzed were obtained from National Health Nutrition Examination Survey 1999–2014. relationship was determined through Cox proportional hazard regression analysis coupled with multivariable adjustments. Two-piecewise linear models penalized...
The mechanisms of statins relieving the no-reflow phenomenon and effects single-dose on it are not well known. This study sought to investigate inflammation in a rabbit model acute myocardial infarction reperfusion (AMI/R) evaluate atorvastatin no-reflow. Twenty-four New Zealand white male rabbits (5-6 months old) were randomized three groups eight: sham-operated group, an AMI/R atorvastatin-treated group (10 mg/kg). Animals latter two subjected 4 h coronary occlusion followed by 2...
We have developed and validated a rapid, selective sensitive method using high-performance liquid chromatography–tandem mass spectrometry (MS) for the quantification of ticagrelor all its as-yet-identified metabolites in human plasma urine. For analysis ticagrelor, internal standard (IS) samples were processed by liquid–liquid extraction ethyl acetate urine was protein precipitation. Separations performed on an Ultimate XB-C18 column (2.1 mm × 150 mm, 3 μm), aqueous ammonium (0.025...
Background: Although many cardiovascular disease studies have focused on the microRNAs of circulating exosomes, profile and potential clinical diagnostic value plasma exosomal long RNAs (exoLRs) are unknown for acute myocardial infarction (AMI). Methods: In this study, exoLR 10 AMI patients, eight stable coronary artery (CAD) healthy individuals was assessed by RNA sequencing. Bioinformatic approaches were used to investigate characteristics exoLRs. Results: Exosomal mRNAs comprised majority...
Profilin-1 (PFN1) regulates the dynamic balance of actin and plays an important role in cell functions as a hub protein signaling molecule interaction networks. Dysregulation PFN1 is related to pathologic kidney diseases. Diabetic nephropathy (DN) was recently reported inflammatory disorder, however, molecular mechanisms DN remain unclear. Therefore, present study conducted explore bioinformatic characteristics DN.Bioinformatics analyses were performed on chip database tissues. A cellular...
Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related pharmacokinetics on recovery platelet function after dose ticagrelor was orally administered healthy Chinese subjects. Methods: The pharmacokinetic profiles and its metabolite AR-C124910XX (M8), aggregation (PA), were assessed 180 mg single-dose 51 Effects CYP2C19*2, CYP2C19*3, CYP3A5*3, UGT1A1*6, UGT1A1*28, UGT2B7*2, UGT2B7*3, SLCO1B1 388A>G, 521T>C, M8, investigated....
The association of total choline (TC) intake and its metabolite trimethylamine-N-oxide (TMAO) with hypertension blood pressure (BP) has not been elucidated.For the population study, TC hypertension, as well pressure, was determined through logistic along multiple linear regression analysis from National Health Nutrition Examination Survey 2007 to 2018, respectively. For animal experimental spontaneously hypertensive rats (SHRs) were assigned water group or containing 333 mg/L 1 g/L TMAO...
Background and purpose: Previous observational studies have yielded conflicting results regarding the association between cheese intake atherosclerosis. Also, relative contribution to each subtype (coronary atherosclerosis, peripheral cerebral arterial stiffness) remains unclear. The primary objective of this investigation was assess causal Methods: A two-sample Mendelian randomization (MR) study conducted based on summary statistics from published genome-wide associations (n = 451,486...
The causal association between particulate matter 2.5 (PM2.5) and Alzheimer's disease (AD) remains inconclusive, the mediators of have yet to be explored.
<title>Abstract</title> <bold>Background:</bold> Predicting protein-DNA binding sites in vivo is a challenging but urgent task many fields such as drug design and development. Most promoters contain transcription factor (TF) sites, only small number of have been identified by time-consuming biochemical experiments. To address this challenge, numerous computational approaches proposed to predict TF from DNA sequences. However, current deep learning methods often face issues gradient vanishing...
Introduction Alzheimer’s disease (AD) and ambient particulate matter 10 (PM10) have been associated in epidemiological studies. However, the relationship between PM10 risk of AD has not proven to be causal. Thus we used two-sample multivariable Mendelian randomization (MR) examine this relationship. Material methods Genome-wide association studies (GWAS) for from UK Biobank, EBI GWAS IEU OpenGWAS were discovery replication, respectively. Pooled meta-analysis inverse variance weighted (IVW)...
Background . Both cis - and trans -cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method simultaneously determine both isomers for pharmacokinetic bioequivalence studies. Methods An LC-MS/MS method, using stable isotope-labeled cefprozil as the internal standard, was developed validated. The analytes were extracted from plasma by protein precipitation separated on reverse-phase C 18 column gradient program...
A rapid, sensitive and selective ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS) method was developed validated for the quantification of atorvastatin all its as-yet-identified metabolites in human plasma.
Background and Aim. The senescence of human bone marrow mesenchymal stem cells (hBMSCs) can be induced by oxidative stress, but the mechanism which it occurs is not yet clear. Here, we performed an investigation on pathogenesis hypoxia-induced through proteomic analyses aimed to explore mechanisms cell senescence. Methods. Hypoxia in hBMSCs was for 0, 4, 12 hours, cellular evaluated senescence-associated β-galactosidase (SA-β-gal) staining. Tandem mass tag (TMT) labeling combined with liquid...