A5066047345- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Oxidative Organic Chemistry Reactions
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Sulfur-Based Synthesis Techniques
- Advanced Chemical Sensor Technologies
- Non-Destructive Testing Techniques
- Extracellular vesicles in disease
- Catalytic Cross-Coupling Reactions
- Metabolomics and Mass Spectrometry Studies
- Lubricants and Their Additives
- Gut microbiota and health
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Gas Sensing Nanomaterials and Sensors
- Mineral Processing and Grinding
- Cancer survivorship and care
- Electrocatalysts for Energy Conversion
- Mycobacterium research and diagnosis
- Synthetic Organic Chemistry Methods
- interferon and immune responses
Jiaxing University
2024
Dalian Maritime University
2022-2024
Zhejiang Sci-Tech University
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Guangdong Academy of Sciences
2020-2024
University of South Florida
2018-2023
Shantou University
2013-2023
Cancer Hospital of Shantou University Medical College
2014-2023
Shantou University Medical College
2019-2023
Jinan University
2019-2023
The gold-catalyzed intermolecular oxyarylation of alkenes is reported. This work employed the oxidative addition aryl iodides to Me-DalphosAu
Abstract Due to the high oxidation potential between Au I and III , gold redox catalysis requires at least stoichiometric amounts of a strong oxidant. We herein report first example an electrochemical approach in promoting gold‐catalyzed oxidative coupling terminal alkynes. Oxidation was successfully achieved through anode oxidation, which enabled facile access either symmetrical or unsymmetrical conjugated diynes homo‐coupling cross‐coupling. This extends reaction scope this transformation...
Pyroptosis is inflammation-associated caspase-1-dependent programmed cell death, which confers a crucial role in sepsis. The present study intends to investigate the regulatory network and function of microarray-predicted YTHDF1 pyroptosis Peripheral blood patients with sepsis was collected determine WWP1 expression. An vitro model induced RAW264.7 cells using lipopolysaccharide (LPS) ATP an vivo septic mouse by cecal ligation perforation (CLP). After gain- loss-of-function assays vivo,...
Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N as the optimal choice, giving aminoarylation with good yields (up to 80 %) and excellent stereoselectivity 99 : 1 er). As first example enantioselective catalysis, this work confirmed feasibility applying a ligand at gold(I) stage, stereodetermining step (SDS) gold(III) intermediate, thus opening up new way conduct catalysis stereochemistry control.
Abstract Stereoselective thioallylation of alkynes under possible gold redox catalysis was accomplished with high efficiency (as low as 0.1 % catalyst loading, up to 99 yield) and broad substrate scope (various alkynes, inter‐ intramolecular fashion). The gold(I) acts both a π‐acid for alkyne activation Au I/III coupling, whereas the sulfonium cation generated in situ functions mild oxidant. This novel methodology provides an exciting system without need strong
Tracking the dynamic modules (modules change over time) during cancer progression is essential for studying pathogenesis, diagnosis, and therapy. However, current algorithms only focus on detecting from temporal networks without integrating heterogeneous genomic data, thereby resulting in undesirable performance. To attack this issue, we propose a novel algorithm (aka TANMF) to detect attributed networks, which integrates gene attributes. obtain modules, temporality are incorporated into an...
Abstract Background Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for therapy, while acquired chemoresistance major obstacle impeding success 5-fluorouracil (5-FU)-based chemotherapy EC, mechanisms underlying resistance not well-understood. In present study, we focus on exploring role long non-coding RNA (lncRNA) HOTAIR EC progression...
The combination of ArB(OH)2 transmetallation with cationic gold(I) [LAu]+ and electrochemical anodic oxidation (EAO) approach was successfully developed for the preparation AuIII-Ar intermediate first time. This in-situ generated aryl gold gave rapid controllable or alkyne followed by reductive elimination to generate either di-aryl coupling sp2-sp Sonogashira-type products under mild conditions no need external oxidants, which significantly extended versatility in promoting redox catalysis.
Expression of the long non-coding mRNA LINC00152 has been reported to correlate with cancer cell resistance oxaliplatin (L-OHP). However, little is known regarding molecular mechanism in esophageal (EC). Hence, we intended characterize role EC, a special focus on epithelial-mesenchymal transition (EMT) and L-OHP resistance.We collected EC tissues identified lines higher resistance, then characterized expression patterns LINC00152, Zeste Homologue 2 (EZH2), Zinc finger e-box binding homeobox...
An electrochemical approach in promoting directed C–H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products good yields (up 95%) without addition any other external oxidants. transformation suitable for various directing groups H2 as only byproduct, which warrants a high atom economy and practical oxidative...
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes CAD and their potential causal effects impacts left ventricular remodeling remains limited. We aim to assess contribution plasma metabolites risk death major adverse cardiovascular events (MACE) as well remodeling. Results In prospective study with 1606 Chinese patients CAD, we have identified validated several independent through...
This study was conducted to investigate the biomarkers that appear be correlated with cancer‑related fatigue (CRF) and adverse reactions (ADRs) chemotherapy. A total of 100 lung cancer patients were selected CRF prior following chemotherapy evaluated. The plasma levels tumor necrosis factor (TNF)‑α interleukin (IL)‑1 level 17‑hydroxycorticosteroid (17‑OHCS) in urine analyzed ADRs associated incidence found 88.0% occurred 15.0% patients. An increase TNF‑α IL‑1 detected CRF. 17‑OHCS elevated...
Fluorouracil (5-FU) has been wildly used as a primary medication in the treatment of solid tumors including colorectal cancer. The efficacy and toxicity 5-FU varies greatly among individuals, suggesting need for individualized regimen cancer patients. present study analyzed blood concentration its therapeutic toxicity, evaluated relationship AUC (area under plasma concentration-time curve), protein expression DPD (dihydropyrimidine dehydrogenase) TS (thymidylate synthetase), toxicity. It was...
Abstract Background: Postpartum depression (PPD) is a common serious mental health problem. Recent studies have demonstrated that hormone therapy serves as promising therapeutic approach in managing PPD. The present study aims at exploring the role of thyroid (TH), estrogen and progestogen patients with Methods: Initially, PPD were enrolled mouse model was established. serum levels estradiol (E2), progesterone (P), triiodothyronine (T3), thyroxine (T4), free (FT3), (FT4), thyroid-stimulating...
Abstract The gold π-acid activation under electrochemical conditions is achieved. While EAO allows easy access to gold(III) intermediates over alternative chemical oxidation mild conditions, the reported examples so far are limited coupling reactions due rapid Au III reductive elimination. Using aryl hydrazine-HOTf salt as precursors, π-activation reaction mode was realized through relay. Both alkene and alkyne di-functionalization were achieved with excellent functional group compatibility...
Abstract Due to the high oxidation potential between Au I and III , gold redox catalysis requires at least stoichiometric amounts of a strong oxidant. We herein report first example an electrochemical approach in promoting gold‐catalyzed oxidative coupling terminal alkynes. Oxidation was successfully achieved through anode oxidation, which enabled facile access either symmetrical or unsymmetrical conjugated diynes homo‐coupling cross‐coupling. This extends reaction scope this transformation...
Abstract The gold‐catalyzed intermolecular oxyarylation of alkenes is reported. This work employed the oxidative addition aryl iodides to Me−DalphosAu + for formation a Au III −Ar intermediate. better binding ability over O nucleophiles ensured success oxyarylation, giving desired products with broad substrate scope and high efficiency (>50 examples up 95 % yield). One‐pot converting methoxy groups into other allowed achieving alkene difunctionalization construction C−N, C−S, C−C bonds...
Perturbation of tryptophan (TRP) metabolism contributes to the immune escape cancer; however, explored TRP metabolites are limited, and their efficacy in clarifying susceptibility progression esophageal cancer (EC) remains ambiguous. Our study sought evaluate effects metabolic profile on clinical outcomes EC using a Chinese population cohort; develop risk prediction model targeting metabolism.A total 456 healthy individuals as control subjects 393 patients with who were followed up for one...