A5068807343- Gut microbiota and health
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Thyroid Disorders and Treatments
- T-cell and B-cell Immunology
- Parasites and Host Interactions
- Galectins and Cancer Biology
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Autoimmune and Inflammatory Disorders Research
- Caveolin-1 and cellular processes
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Coal and Its By-products
- Dendrimers and Hyperbranched Polymers
- Circular RNAs in diseases
- Lysosomal Storage Disorders Research
- Bone Metabolism and Diseases
- Lipid metabolism and disorders
- Tryptophan and brain disorders
- Nutritional Studies and Diet
Affiliated Hospital of Jiangsu University
2014-2025
Hunan Agricultural University
2025
Jiangsu University
2014-2025
Kunming University of Science and Technology
2025
Shantou University Medical College
2022-2023
Jinan University
2022-2023
Shantou University
2022-2023
Nanjing University of Chinese Medicine
2021-2022
Soochow University
2022
Soochow University
2021-2022
Hashimoto's thyroiditis (HT) represents the most common organ-specific autoimmune disease. Inflammatory factors and Reactive Oxygen Species (ROS) play detrimental roles during pathogenesis of HT. In this study, we found that thyroid follicular cells (TFCs) from HT patients expressed an elevated level interleukin-23 (IL-23), which contributed to autophagy suppression ROS accumulation. Additionally, IL-23-induced accumulation in human TFCs was attributed AKT/mTOR/NF-κB signalling pathway...
This study aimed to comprehensively assess the global, regional, and national burden of esophageal cancer (EC) attributable inadequate vegetable fruit intake from 1990 2019 explore potential impact existing dietary intervention programs on EC prevention. Using Global Burden Disease Study (GBD 2019) database, we conducted descriptive analyses stratified by age, sex, Socio-demographic Index (SDI), regional levels. Temporal trends were assessed using linear regression models, cluster analysis...
Abstract Helminth‐derived products have recently been shown to prevent the development of inflammatory diseases in mouse models. However, most identified immunomodulators from helminthes are mixtures or macromolecules with potentially immunogenic side effects. We previously an immunomodulatory peptide called SJMHE 1 HSP 60 protein Schistosoma japonicum . In this study, we assessed ability affect murine splenocytes and human peripheral blood mononuclear cells ( PBMC s) stimulated by toll‐like...
Loropetalum chinense is a significant small tree and ornamental shrub known for its colorful foliage widely used in landscaping tropical subtropical regions. This study aimed to establish an efficient, tissue culture-independent genetic transformation system L. chinense. Cuttings from two varieties, ‘Xiangnong Xiangyun’ ‘Hei Zhenzhu’, were infected with different strains of Agrobacterium rhizogenes. The results showed that the K599 strain significantly induced hairy roots both demonstrating...
Human γδ T cells display the principal characteristics of professional antigen-presenting (APCs), in addition to playing a vital role immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether perform APC-like functions under pathological conditions. In this study, we showed that, contrast peripheral-derived directly isolated from PBMCs gastric cancer patients, tumor-activated only killed tumor efficiently but also strongly induced primary CD4 + CD8 αβ...
Hashimoto's thyroiditis (HT) is considered a T helper-type 1 (Th1) cytokine-dominant autoimmune thyroid disease. Caveolin-1 (Cav-1), part of the thyroxisome multiprotein complex, localized at apical pole thyrocytes and indispensable for synthesis hormones modulation oxidative stress in order to avoid cell damage apoptosis. Reduced autophagy induces follicular cells (TFC) apoptosis by activating reactive oxygen species (ROS) HT patients. Nevertheless, whether Cav-1 has roles regulation...
Increasing evidence suggests the association between obesity and bone metabolism. However, whether excessive fat accumulation has a beneficial or adverse effect on health remains controversial. Chemerin is novel adipocyte-derived hormone chemoattractant cytokine that regulates adipogenesis. This study was performed to investigate associations of serum chemerin with mineral density (BMD) pro-inflammatory levels in 543 Chinese obese postmenopausal women. BMD femoral neck lumbar spine, lean...
In the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a pro-inflammatory molecule that exhibits pro- or anti-tumor properties, but both activities remain poorly understood. this study, we investigated effect of extracellular IL-23 in receptor-positive (IL-23R+) esophageal squamous cell carcinoma (ESCC) explored mechanisms underlying effect. We analyzed ESCC tissues by immunohistochemical immunofluorescence...
Parasite-derived molecules with immunomodulatory properties, which have been optimised during host-parasite co-evolution, exhibit potential applications as novel immunotherapeutics. We previously demonstrated that Schistosoma japonicum HSP60-derived peptide SJMHE1 induces CD4+CD25+ regulatory T-cells (Tregs) and adoptively transferred SJMHE1-induced Tregs inhibit delayed-type hypersensitivity (DTH) in mice. However, multiple concerns regarding this method render treatment unsuitable. To gain...
Circular RNA (circRNA) is a type of noncoding that can interact with miRNAs to regulate gene expression. However, little known concerning circRNA, which crucial in the pathogenesis lung cancer. To date, limited studies have explored role circ_0044516 cancer progression. Recently, we observed expression levels were obviously elevated tissues and cells. A549 SPCA1 cells transfected siRNA. We knockdown dramatically repressed cell proliferation, increased apoptosis, cycle. Moreover, migration...
Perturbation of tryptophan (TRP) metabolism contributes to the immune escape cancer; however, explored TRP metabolites are limited, and their efficacy in clarifying susceptibility progression esophageal cancer (EC) remains ambiguous. Our study sought evaluate effects metabolic profile on clinical outcomes EC using a Chinese population cohort; develop risk prediction model targeting metabolism.A total 456 healthy individuals as control subjects 393 patients with who were followed up for one...
The present study aimed to investigate the effect of echinacoside on autophagy-related indicators through mTOR signaling pathway, especially clearance autophagy substrate P62 and α-synuclein, core pathological products Parkinson's disease (PD), provide new strategies for treatment PD.A mouse model subacute PD was established by intraperitoneal injection 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). First, neurobehavioral symptoms in mice each group were evaluated, monoamine...
Chemoresistance remains a major obstacle to the treatment of esophageal cancer (EC). Exosome-mediated transfer long noncoding RNAs (lncRNAs) has recently been unveiled correlate with regulation drug resistance in EC. This study aimed investigate physiological mechanisms by which exosome-encapsulated lncRNA myocardial infarction-associated transcript (MIAT) derived from tumor cells might mediate paclitaxel (PTX) EC cells. First, MIAT was experimentally determined be upregulated PTX...
The activating immunoreceptor NKG2D (natural killer group 2, member D) and its ligands play important roles in the innate adaptive immune responses. UL16-binding protein 3 (ULBP3), an ligand, is overexpressed on certain epithelial tumor cells. In this study, we investigated effect of ULBP3 expression cytotoxic activity natural (NK) were measured by flow cytometry analysis, immunohistochemistry, time-resolved fluoroimmunoassay. cytotoxicity NK cells was determined with lactate dehydrogenase...
Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto's thyroiditis (HT) still not clear. In this study, we examined status of in thyroid tissues sera HT patients explored mechanism IL-1β-mediated regulation expression, as well effects on pro-inflammatory chemokine secretion follicular cells (TFCs), to elucidate role development. Our results showed dramatically increased expression from patients. addition, IL-1β...
Hashimoto's thyroiditis (HT) is a very common organ-specific autoimmune disease characterized by lymphocyte infiltration and the destruction of thyroid follicular cells (TFCs), in which IFN-γ chemokines play pivotal roles. Moreover, β-catenin has been implicated regulation T cell infiltration. However, whether involved unknown. Here, we examined expression tissues investigated its role pathogenesis HT. The results showed that was markedly reduced HT patients; more importantly, treatment...
Cholestasis is characterized by bile acid (BA) circulation disorders, which usually related to damage of hepatocyte barrier function. Currently, patients with cholestasis face several obstacles in seeking diagnosis and therapy. Da-Huang-Xiao-Shi decoction (DHXSD) an ancient classic formula that has been used clinically for treatment. Nevertheless, the underlying biological activities therapeutic mechanisms remain unclear. In this study, alpha-naphthylisothiocyanate (ANIT)-induced rat model...