A5100739582- Functional Brain Connectivity Studies
- Higher Education and Teaching Methods
- Distributed Control Multi-Agent Systems
- Target Tracking and Data Fusion in Sensor Networks
- Alzheimer's disease research and treatments
- Health Literacy and Information Accessibility
- Cytokine Signaling Pathways and Interactions
- Civil and Geotechnical Engineering Research
- RNA modifications and cancer
- Metallurgy and Material Forming
- Cancer Cells and Metastasis
- Guidance and Control Systems
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Parkinson's Disease Mechanisms and Treatments
- Phytochemistry and biological activities of Ficus species
- MRI in cancer diagnosis
- Toxin Mechanisms and Immunotoxins
- Microstructure and Mechanical Properties of Steels
- Berberine and alkaloids research
- Acupuncture Treatment Research Studies
- Ginger and Zingiberaceae research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pediatric health and respiratory diseases
- Traditional Chinese Medicine Studies
China Pharmaceutical University
2022-2025
Beihang University
2023-2024
Xi'an Jiaotong University
2022-2024
Zhejiang A & F University
2024
Changchun University
2023
Chinese Academy of Social Sciences
2023
Institute of Industrial Economics
2023
China Telecom
2023
China Telecom (China)
2023
Xinjiang University
2023
APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, member of the ATP-binding cassette family active transporters, lipidates apoE in CNS. Abca1–/– mice have decreased lipid associated with and increased amyloid deposition several AD mouse models. We hypothesized that overexpressing ABCA1 brain would lipidation apoE-containing lipoproteins deposition. To address these hypotheses, we created PrP-mAbca1 Tg overexpress Abca1 throughout under control prion...
北京 100093) 2 (中国科学院华南植物园, 广州 510650) 3 (中国科学院大学生命科学学院, 100049) 4 (北京师范大学生命科学学院, 100875) 5 (中央民族大学生命科学学院, 100081) 6 (上海辰山植物园, 中国科学院上海辰山植物科学研究中心, 上海 201602) 7 (西南林业大学云南生物多样性研究院, 昆明 650224) 8 (中国科学院昆明植物研究所东亚植物多样性与生物地理学重点实验室, 650201) 9 (北京林业大学自然保护区学院, 100083) 10 (四川大学生命科学学院, 成都 610064) 11 (中国科学院新疆生态与地理研究所, 乌鲁木齐 830011) 12 (中国医学科学院北京协和医学院药用植物研究所, 100193) 13 (曲阜师范大学生命科学院, 山东曲阜 273165) 14 (广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006) 15 (江苏省中国科学院植物研究所, 南京 210014) 16 (中国科学院沈阳应用生态研究所, 沈阳 110016) 17 (中国科学院武汉植物园,...
The small-world organization has been hypothesized to reflect a balance between local processing and global integration in the human brain. Previous multimodal imaging studies have consistently demonstrated that topological architecture of brain network is disrupted Alzheimer's disease (AD). However, these reported inconsistent results regarding properties alterations AD. One potential explanation for lies with diverse homogeneity distinct progressive stages AD involved studies, which are...
Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-beta (Abeta) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated deletion of the ATP-binding cassette A1 transporter (ABCA1) in mice causes dramatic reductions cerebrospinal fluid (CSF) apoE lipidation. To examine whether polymorphisms ABCA1 affect CSF humans, we measured taken from 168 subjects who were 43 to 91 years old either cognitively normal or had mild AD. then...
RNA-binding proteins (RBPs) play essential roles in RNA metabolism, regulating splicing, transport, surveillance, decay and translation. The aberrant expression of RBPs leads to gene alteration frequently causes various diseases, such as cancer. In this study, we are the first provide evidence that hMex-3A, a RBP belongs human Mex-3 family with two K-homology domains, is involved regulation tumorigenesis. We show silencing hMex-3A by small interference effectively inhibits cell proliferation...
Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of FOXM1 circulating exosomes role exosome gastric cancer (GC) were not clear. This study aims investigate potential related long noncoding RNA (FRLnc1) GC.The prepared CD63 immunomagnetic beads (CD63-IMB) had characteristics good dispersity high magnetic response. The isolated presented...
High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is widely used to treat depression. However, the underlying mechanism has not been identified, and there uncertainty regarding optimal choice of stimulus parameters, especially frequency. Our previous study in mice demonstrated that 10-Hz HF-rTMS ameliorated depression by inducing expression Homer1a reducing excitability cortical pyramidal cells. The aims this were compare effects 15-Hz 25-Hz a model chronic unpredictable...
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Nanodrug-delivery systems modified with targeting molecules allow antitumor drugs to localize tumor sites efficiently. CD147 protein is expressed highly on hepatoma cells. Firstly, we synthesized magnetothermally responsive nanocarriers/doxorubicin (MTRN/DOX) which was composed of manganese zinc (Mn-Zn) ferrite magnetic nanoparticles, amphiphilic and thermosensitivity copolymer drug carriers together DOX. Then CD147-MTRN/DOX formed MTRN/DOX monoclonal antibody that specifically binds...
Fluorouracil (5-FU) has been wildly used as a primary medication in the treatment of solid tumors including colorectal cancer. The efficacy and toxicity 5-FU varies greatly among individuals, suggesting need for individualized regimen cancer patients. present study analyzed blood concentration its therapeutic toxicity, evaluated relationship AUC (area under plasma concentration-time curve), protein expression DPD (dihydropyrimidine dehydrogenase) TS (thymidylate synthetase), toxicity. It was...
Tumor cells with heterogeneity and diversity can express different markers. At present, positive separation of circulating tumor (CTC) taking EpCAM as the marker was used in most cases which could be one-sided, while this study successfully prepared four antibody-modified magnetic immunoliposomes (MIL) by using self-assembled liposome antibody derivatives. This aims to explore efficiency clinical detection feasibility single or combined use MIL multi-tumor markers on tumors. Captured CTC...
北京 100049) 3 (北京师范大学生命科学学院, 100875) 4 (中央民族大学生命科学学院, 100081) 5 (中国科学院华南植物园, 广州 510650) 6 (中国科学院昆明植物研究所东亚植物多样性与生物地理学重点实验室, 昆明 650201) 7 (北京林业大学自然保护区学院, 100083) 8 (四川大学生命科学学院, 成都 610064) 9 (中国科学院新疆生态与地理研究所, 乌鲁木齐 830011) 10 (中国医学科学院北京协和医学院药用植物研究所, 100193) 11 (曲阜师范大学生命科学学院, 山东曲阜 273165) 12 (广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006) 13 (江苏省中国科学院植物研究所, 南京 210014) 14 (中国科学院沈阳应用生态研究所, 沈阳 110016) 15 (中国科学院武汉植物园, 武汉 430074) 16 (中国科学院西北高原生物研究所, 西宁 810008) 17 (云南大学生命科学学院, 650091) 18 (中国科学院植物研究所植被与环境变化国家重点实验室,...
Patients with persistent somatoform pain disorder (PSPD) suffer from long-term and emotional conflicts. Recently, accumulating evidence indicated that emotion has a significant role in perception of disorder. To further understand the association between pain-related brain activities, functional activities patients PSPD fulfilling ICD-10 criteria healthy controls were assessed using magnetic resonance imaging technology, while participants viewed series positive, neutral, or negative...
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