A5100709762- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Platelet Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Angiogenesis and VEGF in Cancer
- Heart Failure Treatment and Management
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Esophageal Cancer Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Syncope and Autonomic Disorders
- Inflammasome and immune disorders
Hope Center for Neurological Disorders
2024
China-Japan Friendship Hospital
2024
Renmin Hospital of Wuhan University
2011-2023
Dalian Medical University
2023
Wuhan Third Hospital
2023
Yichang Central People's Hospital
2023
Wuhan University
2011-2023
Fudan University
2020
Sun Yat-sen University
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Prior studies have shown that PI3Ks play a necessary but incompletely defined role in platelet activation. One potential effector for PI3K is the serine/threonine kinase, Akt, whose contribution to activation was explored here. Two isoforms of Akt were detected mouse platelets, with expression Akt2 being greater than Akt1. Deletion gene encoding impaired aggregation, fibrinogen binding, and granule secretion, especially response low concentrations agonists activate Gq-coupled receptors...
Prior studies have shown that PI3Ks play a necessary but incompletely defined role in platelet activation. One potential effector for PI3K is the serine/threonine kinase, Akt, whose contribution to activation was explored here. Two isoforms of Akt were detected mouse platelets, with expression Akt2 being greater than Akt1. Deletion gene encoding impaired aggregation, fibrinogen binding, and granule secretion, especially response low concentrations agonists activate Gq-coupled receptors...
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk developing late-onset Alzheimer's Disease (AD), but the mechanism underlying this link is poorly understood. In particular, relevance direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all associate with Aβ in early stages aggregation then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ~50% mass diffusible aggregates detected frontal...
Platelet responses at sites of vascular injury are regulated by intracellular cAMP levels, which rise rapidly when prostacyclin (PGI2) is released from endothelial cells. agonists such as ADP and epinephrine suppress PGI2-stimulated formation activating receptors coupled to Gi family members, four present in platelets. To address questions about the specificity receptor:G protein coupling, regulation vivo contribution Gi-mediated pathways that do not involve adenylyl cyclase, we studied...
High mobility group box 1 protein (HMGB1) has an important role in myocardial ischemia/reperfusion (I/R) injury. Sodium butyrate, inhibitor of histone deacetylase, been shown to inhibit HMGB1 expression. In the present study, effect sodium butyrate on I/R injury rats was investigated. Anesthetized male were intraperitoneally administered (100 or 300 mg/kg) 30 min prior induction ischemia. The then subjected ischemia for followed by reperfusion 4 h. Infarct size, lactate dehydrogenase (LDH),...
Background/Aims: Inflammation and oxidative stress play an important role in myocardial ischemia reperfusion (I/R) injury. We hypothesized that IL-23, a pro-inflammatory cytokine, could promote I/R injury by increasing the inflammatory response stress. Methods: Male Sprague-Dawley rats were randomly assigned into sham operated control (SO) group, (IL-23 + I/R) group (anti-IL-23 group. At 4 h after reperfusion, serum concentration of lactate dehydrogenase (LDH), creatine kinase (CK) tissue...
Toll-like receptor 4 (TLR4) serves as an important inducer of apoptotic and autophagic responses in myocardial ischemia/reperfusion (I/R) injury (MIRI). Radioprotective 105 kDa protein (RP105) is a specific inhibitor TLR4. However, the molecular mechanisms by which RP105 represses apoptosis autophagy through TLR4‑mediated signaling during I/R have not yet been fully elucidated. Therefore, present study, we aimed to examine whether adenovirus-mediated overexpression repressed inhibiting...
J. Neurochem. (2012) 122 , 834–843. Abstract Src homology 2 domain–containing protein tyrosine phosphatase substrate–1 (SHPS‐1), also known as Signal‐regulatory alpha (SIRPα) or SIRPA is a transmembrane that predominantly expressed in neurons, dendritic cells, and macrophages. This study was conducted to investigate the role of SHPS‐1 oxidative stress brain damage induced by acute focal cerebral ischemia. Wild‐type (WT) mutant (MT) mice were subjected middle artery occlusion (60 min)...
Interleukin-33 (IL-33) plays a protective role in myocardial ischemia and reperfusion (I/R) injury, but the underlying mechanism was not fully elucidated. The present study designed to investigate whether IL-33 protects against I/R injury by regulating both P38 mitogen-activated-protein kinase (P38 MAPK), which is involved one of downstream signaling pathways IL-33, high mobility group box protein 1 (HMGB1), late pro-inflammatory cytokine. Myocardial increased level its induced receptor...
Cardiovascular ischemic disease refers to a large class of conditions that are harmful human health. A number previous studies have demonstrated microRNAs (miRs) notable roles in regulating cardiac injury. miR-144 is influential the differentiation, growth, and metastatic processes cells; however, impact ischemia/reperfusion (I/R) injury has not been thoroughly elucidated date. In present study, reverse transcription quantitative polymerase chain reaction was used evaluate RNA expression....
Background: Cardiogenic shock complicating acute myocardial infarction (AMICS) remains a high 30-day mortality. Mechanical circulatory support devices are increasingly used in AMICS, but their effects on mortality vary partly because of severity. Aims: This study aimed to evaluate the association between intra-aortic balloon pump (IABP) and patients with early-stage AMICS. Methods: We retrospectively analyzed ST-segment elevation (STEMI) based multicenter clinical trial (NCT04996901)....